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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">glaucoma</journal-id><journal-title-group><journal-title xml:lang="ru">Национальный журнал Глаукома</journal-title><trans-title-group xml:lang="en"><trans-title>National Journal glaucoma</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-4104</issn><issn pub-type="epub">2311-6862</issn><publisher><publisher-name>Federal State Budgetary Institution of Science “Krasnov Research Institute of Eye Diseases”</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">glaucoma-120</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW OF LITERATURE</subject></subj-group></article-categories><title-group><article-title>Исследования оксигенации в офтальмологии</article-title><trans-title-group xml:lang="en"><trans-title>Investigations of oxygenation in ophthalmology</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петров</surname><given-names>С. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrov</surname><given-names>S. Yu.</given-names></name></name-alternatives><email xlink:type="simple">post@glaucomajournal.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Антонов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Antonov</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новиков</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Novikov</surname><given-names>I. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Волжанин</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Volzhanin</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Савельева</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Savel’Eva</surname><given-names>T. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рябова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ryabova</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лощенов</surname><given-names>В. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Loshchenov</surname><given-names>V. B.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт глазных болезней»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>The Scientific Research Institute of Eye Diseases</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Институт общей физики им. А.М. Прохорова РАН; Национальный исследовательский ядерный университет «Московский инженерно-физический институт»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of General Physics of RAS; National Research Nuclear University «Moscow Engineering Physics Institute»</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Институт общей физики им. А.М. Прохорова РАН; Национальный исследовательский ядерный университет «Московский инженерно-физический институт»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of General Physics of RAS; National Research Nuclear University «Moscow Engineering Physics Institute»</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Институт общей физики им. А.М. Прохорова РАН; Национальный исследовательский ядерный университет «Московский инженерно-физический институт»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of General Physics of RAS; National Research Nuclear University «Moscow Engineering Physics Institute»</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>17</day><month>01</month><year>2017</year></pub-date><volume>15</volume><issue>3</issue><fpage>71</fpage><lpage>80</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Петров С.Ю., Антонов А.А., Новиков И.А., Волжанин А.В., Савельева Т.А., Рябова А.В., Лощенов В.Б., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Петров С.Ю., Антонов А.А., Новиков И.А., Волжанин А.В., Савельева Т.А., Рябова А.В., Лощенов В.Б.</copyright-holder><copyright-holder xml:lang="en">Petrov S.Y., Antonov A.A., Novikov I.A., Volzhanin A.V., Savel’Eva T.A., Ryabova A.V., Loshchenov V.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.glaucomajournal.ru/jour/article/view/120">https://www.glaucomajournal.ru/jour/article/view/120</self-uri><abstract><p>Важным показателем жизнеобеспечения является содержание кислорода в жидкостях и тканях организма. Ряд патологий зрительного анализатора, такие как глаукома, предположительно, имеют сосудистый генез, заключающийся в нарушении кровоснабжения и циркуляции кислорода. Большая его часть переносится кровью в виде химического соединения с гемоглобином. Проходя через капилляры, гемоглобин отдает кислород, превращаясь из оксигенированного в дезоксигенированный. Этот процесс сопровождается изменением спектральных характеристик гемоглобина, что обуславливает цвета артериальной и венозной крови. На различиях поглощения света разными формами гемоглобина основан фотометрический метод измерения степени насыщения крови кислородом (сатурация). Для ее измерения проводят оксиметрию. В медицине наиболее распространена тканевая пульсоксиметрия с оценкой показателя тканевой оксигенации. В офтальмологии данный метод использовался при изучении сатурации крови при глаукоме и исследовании эффективности методов ее терапии. Отдельным методом оценки концентрации кислорода является измерение давления растворенного кислорода в крови - парциальное давление кислорода. В офтальмологии исследования данного показателя проводили в жидкости передней камеры, оценивая содержание кислорода при ряде офтальмопатий, включающих различные формы глаукомы, при инстилляциях гипотензивных препаратов, а также в стекловидном теле в области диска зрительного нерва при различных уровнях внутриглазного давления. В настоящее время хорошо развито направление исследования сатурации в сосудах сетчатки - ретинальная оксиметрия, основанная на исследовании поглощения света кровью в зависимости от насыщения гемоглобина кислородом путем анализа спектрального состава света, отраженного от сетчатки. Также проводят оксиметрию эписклерально-конъюнктивальной сосудистой сети, позволяющую оценить сатурацию сосудов, принимающих кровь от переднего отрезка глаза и характеризующих состояние его метаболизма при ряде патологий, а также в процессе лечения.</p></abstract><trans-abstract xml:lang="en"><p>Oxygen content in body fluids and tissues is an important indicator of life support functions. A number of ocular pathologies, e.g., glaucoma, are of presumable vascular origin which means altered blood supply and oxygen circulation. Most oxygen is transported in blood bound to hemoglobin. When the blood is passing through the capillaries, oxygen releases, i.e., oxygenated hemoglobin converts into deoxygenated hemoglobin. This process is accompanied by the changes in spectral characteristics of hemoglobin which result in different colors of arterial and venous blood. Photometric technique for the measurement of oxygen saturation in blood is based on the differences in light absorption. Blood oxygen saturation is measured by oximetry. In medicine, the most common method is pulse oximetry which assesses tissue oxygenation. In ophthalmology, this technique was applied to study blood saturation in glaucoma and to analyze the efficacy of glaucoma therapy. Oxygen concentration can also be evaluated by measuring oxygen partial pressure, i.e., pressure from the dissolved oxygen in blood. In ophthalmological practice, this parameter was measured in anterior chamber fluid in glaucoma after instillations of hypotensive eye drops as well as in vitreous body near to the optic disc under various levels of intraocular pressure. Currently, retinal oximetry allows for the calculation of oxygen saturation in retinal blood vessels. This technique is based on the assessment of light absorption with blood depending on hemoglobin saturation with oxygen by analyzing spectral composition of light reflected from the retina. Oximetry of bulbar conjunctival and episcleral microvasculature can be performed as well. This technique allows for the evaluation of oxygen saturation in vessels which collect blood from the anterior segment and the characterization of anterior segment metabolism in a number of ocular pathologies and in the course of treatment.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>оксигемоглобин</kwd><kwd>дезоксигемоглобин</kwd><kwd>оксигемометрия</kwd><kwd>пульсоксиметрия</kwd><kwd>парциальное давление кислорода</kwd><kwd>ретинальная оксиметрия</kwd><kwd>сатурация</kwd><kwd>oxyhemoglobin</kwd><kwd>deoxyhemoglobin</kwd><kwd>oximetry</kwd><kwd>pulse oximetry</kwd><kwd>oxygen partial pressure</kwd><kwd>retinal oximetry</kwd><kwd>saturation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Pflüger E.F.W. 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