glaucomaНациональный журнал ГлаукомаNational Journal glaucoma2078-41042311-6862Federal State Budgetary Institution of Science “Krasnov Research Institute of Eye Diseases”glaucoma-153Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEW OF LITERATUREГанглиозные клетки сетчатки: возможности нейропротекции при глаукомеRetinal ganglion cells: potentiality for neuroprotective glaucoma treatmentГабашвилиА. Н.GabashviliA. N.

к.б.н., научный сотрудник лаборатории фундаментальных исследований в офтальмологии,

119021,  Москва, ул. Россолимо, 11А, Б

Ph.D., Research Associate, Laboratory of Fundamental Research in Ophthalmology,

11А Rossolimo st., Moscow, 119021

gabashvili.anna@gmail.comЕричевВ. П.ErichevV. P.

д.м.н., профессор, руководитель отдела глаукомы,

119021,  Москва, ул. Россолимо, 11А, Б

Med.Sc.D., Professor, Head of the Glaucoma Department,

11А Rossolimo st., Moscow, 119021

НестероваТ. В.NesterovaT. N.

лаборант-исследователь лаборатории фундаментальных исследований в офтальмологии,

119021,  Москва, ул. Россолимо, 11А, Б

Research Assistant, Laboratory of Fundamental Research in Ophthalmology,

11А Rossolimo st., Moscow, 119021

СубботА. М.SubbotA. M.

к.м.н., старший научный сотрудник лаборатории фундаментальных исследований в офтальмологии,

119021,  Москва, ул. Россолимо, 11А, Б

Ph.D., Senior Research Associate, Laboratory of Fundamental Research in Ophthalmology,

11А Rossolimo st., Moscow, 119021

ФГБНУ «Научно-исследовательский институт глазных болезней»РоссияScientific Research Institute of Eye DiseasesRussian Federation2017300820171627481Copyright © Габашвили А.Н., Еричев В.П., Нестерова Т.В., Суббот А.М., 20172017Габашвили А.Н., Еричев В.П., Нестерова Т.В., Суббот А.М.Gabashvili A.N., Erichev V.P., Nesterova T.N., Subbot A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.glaucomajournal.ru/jour/article/view/153

Нейропротекторная терапия является современным и одним из наиболее перспективных направлений в лечении глаукомы. Эта стратегия подразумевает защиту сетчатки, а также волокон зрительного нерва от повреждающего действия различных факторов. Клеточная терапия постепенно находит практическое применение почти во всех областях клинической медицины, в том числе и в офтальмологии. Считается, что положительное влияние трансплантации клеток обусловлено нескольки- ми механизмами, одним из которых является трофический, поэтому одним из важных аспектов нейропротекции при глаукоме является коррекция метаболического стресса клеток сетчатки.

В обзоре анализируется современное состояние вопроса изучения ганглиозных клеток сетчатки как мишени для терапии глаукомы, дается представление о новых подходах к лечению этого заболевания с использованием клеточных технологий на основе стратегии нейропротекции. 

Neuroprotective therapy is a contemporary and promising direction in glaucoma treatment. This strategy involves retinal protection, as well as the protection of optic nerve fibers from damaging by various factors. Cell therapy is gradually finding its practical application in almost all areas of clinical medicine, including ophthalmology. The positive effect of cell transplantation is associated with several mechanisms, including the trophic one and therefore, retinal cells metabolic stress correction is an important aspect of neuroprotection in glaucoma.

The review analyzes the current state of researching retinal ganglion cells as targets for glaucoma therapy and gives a general idea about the new approaches to the treatment of this disease with the use of cell technologies based on neuroprotection strategies. 

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The authors declare that there are no conflicts of interest present.