glaucomaНациональный журнал ГлаукомаNational Journal glaucoma2078-41042311-6862Federal State Budgetary Institution of Science “Krasnov Research Institute of Eye Diseases”glaucoma-195Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEW OF LITERATUREХРОНОБИОЛОГИЧЕСКИЕ НАРУШЕНИЯ В ПАТОГЕНЕЗЕ АССОЦИИРОВАННЫХ С ВОЗРАСТОМ ЗАБОЛЕВАНИЙ. ЗНАЧЕНИЕ ДЕСИНХРОНИЗАЦИИ БИОЛОГИЧЕСКИХ РИТМОВ В ПАТОГЕНЕЗЕ ПЕРВИЧНОЙ ГЛАУКОМЫCHRONOBIOLOGICAL DISTURBANCES IN THE PATHOGENESIS OF AGE-ASSOCIATED DISEASES. THE SIGNIFICANCE OF BIOLOGICAL RHYTHMS DESYNCHRONIZATION IN THE PATHOGENESIS OF PRIMARY GLAUCOMAМалишевскаяТ. Н.MalishevskayaT. N.

Малишевская Татьяна Николаевна, кандидат медицинских наук, начальник отдела организации медицинской помощи

625048, Тюмень, ул. Холодильная, 118, к.1

Ph.D., Deputy Chief physician

118 Holodilnaya str., Tyumen, 625048

malishevskoff@ya.ruГАУЗ ТО «Областной офтальмологический диспансер»РоссияRegional Ocular Health Clinic, Ministry of public health and Social Development of RussiaRussian Federation201706042018164110120Copyright © Малишевская Т.Н., 20182018Малишевская Т.Н.Malishevskaya T.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.glaucomajournal.ru/jour/article/view/195

В статье представлен обзор последних исследований, посвященных различным аспектам патогенеза ассоциированных с возрастом заболеваний. Описаны современные концепции естественного старения и нарушения адаптационных механизмов, противостоящих инволюционным процессам. Подробно рассмотрена хронобиологическая концепция формирования временной биологической структуры и ключевые компоненты регуляции циркадианной системы. Приведены аргументы в пользу нарушения строгой согласованности различных физиологических процессов во времени при глаукоме. Подчеркнута роль амплитуды колебаний внутриглазного давления (ВГД) в течение дня в качестве достоверного маркера, а также важного патогенетического фактора развития глаукомы. Рассмотрены другие хронобиологические факторы, которые могут быть предикторами возрастных нейродегенеративных заболеваний, в том числе глаукомы. Проанализированы механизмы становления системной десинхронизации — экстрациркадианной диссеминации, а первичная открытоугольная глаукома рассмотрена как десинхроноз-зависимое, ассоциированное с возрастом заболевание. Более того, представлена гипотеза, согласно которой первичная открытоугольная глаукома (ПОУГ) является не только следствием, но и причиной нарушения циркадианной ритмичности

The article presents a review of latest research related to various aspects of age-associated diseases pathogenesis. It describes the modern concepts of natural aging and the disorders of adaptation mechanisms that oppose the involution processes. The chronobiological formation concept of temporary biological structure and the key components of circadian system regulation are reported in detail. Arguments in favor of violations of strong consistency of various physiological processes in glaucoma are recounted. The article emphasizes the role of diurnal IOP amplitude fluctuations as a reliable marker, as well as an important pathogenetic factor of glaucoma development. Other chronobiological factors that may be considered predictors of various age-related neurodegenerative diseases, including glaucoma, are discussed. The review analyzes the mechanisms of system desynchronization development, such as extra-circadian dissemination and the development of primary open-angle glaucoma (POAG). Primary open angle glaucoma is considered to be a desynchronosisrelated, age-associated disease. Moreover, the article presents a hypothesis of POAG being not only a consequence, but also a cause of circadian rhythm disturbance.

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The authors declare that there are no conflicts of interest present.