glaucomaНациональный журнал ГлаукомаNational Journal glaucoma2078-41042311-6862Federal State Budgetary Institution of Science “Krasnov Research Institute of Eye Diseases”10.25700/NJG.2018.04.08glaucoma-215Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEW OF LITERATUREВлияние тафлупроста на суточные колебания офтальмотонуса при первичной открытоугольной глаукомеEffect of tafluprost on the diurnal intraocular pressure fluctuations in patients with primary open-angle glaucomaПетровС. Ю.PetrovS. Yu.

м.н., ведущий научный сотрудник отдела глаукомы.

19021, Москва, ул. Россолимо, 11А.

Med.Sc.D., leading research associate of Glaucoma Dept.

11А Rossolimo st., Moscow, 119021.

ВолжанинА. В.VolzhaninA. V.

аспирант.

19021, Москва, ул. Россолимо, 11А.

postgraduate student.

11А Rossolimo st., Moscow, 119021.

КравчикМ. В.KravchikM. V.

аспирант.

19021, Москва, ул. Россолимо, 11А.

postgraduate student.

11А Rossolimo st., Moscow, 119021.

МазуроваЮ. В.MazurovaYu. V.

врач-офтальмолог, заведующая III хирургическим отделением.

19021, Москва, ул. Россолимо, 11А.

M.D., chief of III Surgical Dept.

11А Rossolimo st., Moscow, 119021.

СапароваЛ. М.SaparovaL. M.

врач-офтальмолог.

19021, Москва, ул. Россолимо, 11А.

M.D.

11А Rossolimo st., Moscow, 119021.

 

ФГБНУ «НИИ глазных болезней».РоссияScientific Research Institute of Eye Diseases.Russian Federation2018291220181749196Copyright © Петров С.Ю., Волжанин А.В., Кравчик М.В., Мазурова Ю.В., Сапарова Л.М., 20182018Петров С.Ю., Волжанин А.В., Кравчик М.В., Мазурова Ю.В., Сапарова Л.М.Petrov S.Y., Volzhanin A.V., Kravchik M.V., Mazurova Y.V., Saparova L.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.glaucomajournal.ru/jour/article/view/215

Терапия глаукомы направлена на стабилизацию офтальмотонуса. Патологические суточные колебания внутриглазного давления (ВГД), как и его среднее зна-чение в течение 24 часов, являются значимым факто-ром риска прогрессирования первичной открытоуголь-ной глаукомы. (ПОУГ). Для коррекции офтальмотонуса используется ряд фармакологических препаратов, кото-рые оказывают различное влияние на офтальмотонус, в том числе и в зависимости от времени их применения. Тафлупрост, относящийся к простагландинам, обла-дает значимым гипотензивным действием и способен эффективно уменьшать размах суточных колебаний у пациентов с ПОУГ.

Glaucoma therapy is directed towards intraocular pressure stabilization. Pathological diurnal fluctuations of intraocular pressure (IOP), as well as its average value during 24 hours, is a significant risk factor or primary open-angle glaucoma (POAG) progression. Currently, a whole range pharmacologi­cal drugs is used for IOP correction. They differ in hypoten­sive effect degree, which, in turn, can depend on the time of administration. Tafluprost, a prostaglandin analogue, has a significant hypotensive effect and can effectively decrease diurnal IOP fluctuations amplitude in patients with POAG.

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The authors declare that there are no conflicts of interest present.