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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">glaucoma</journal-id><journal-title-group><journal-title xml:lang="ru">Национальный журнал Глаукома</journal-title><trans-title-group xml:lang="en"><trans-title>National Journal glaucoma</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-4104</issn><issn pub-type="epub">2311-6862</issn><publisher><publisher-name>Federal State Budgetary Institution of Science “Krasnov Research Institute of Eye Diseases”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25700/NJG.2020.02.09</article-id><article-id custom-type="elpub" pub-id-type="custom">glaucoma-300</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW OF LITERATURE</subject></subj-group></article-categories><title-group><article-title>Терапия неоваскулярной глаукомы</article-title><trans-title-group xml:lang="en"><trans-title>Neovascular glaucoma treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ходжаев</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Khodzhaev</surname><given-names>N. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, профессор, заместитель генерального директора по организационной работе и инновационному развитию</p><p>Отдел хирургического лечения глаукомы</p><p>127486, Москва, Бескудниковский бульвар, дом 59а.</p><p> </p></bio><bio xml:lang="en"><p>Med.Sc.D., Professor, Deputy General Director for Organizational Work and Innovative Development</p><p>Department of Surgical Treatment of Glaucoma</p><p>59a Beskudnikovsky Boulevard, Moscow, 127486</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сидорова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sidorova</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сидорова Алла Валентиновна, врач-офтальмолог высшей категории, заведующая отделением хирургического лечения глаукомы</p><p>Отдел хирургического лечения глаукомы</p><p>127486, Москва, Бескудниковский бульвар, дом 59а.</p><p> </p></bio><bio xml:lang="en"><p>M.D., Head of the Glaucoma Surgical Treatment Department</p><p>Department of Surgical Treatment of Glaucoma</p><p>59a Beskudnikovsky Boulevard, Moscow, 127486</p></bio><email xlink:type="simple">sidorova@mntk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смирнова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Smirnova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аспирант</p><p>Отдел хирургического лечения глаукомы</p><p>127486, Москва, Бескудниковский бульвар, дом 59а.</p></bio><bio xml:lang="en"><p>Postgraduate</p><p>Department of Surgical Treatment of Glaucoma</p><p>59a Beskudnikovsky Boulevard, Moscow, 127486</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Елисеева</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Eliseeva</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аспирант</p><p>Отдел хирургического лечения глаукомы</p><p>127486, Москва, Бескудниковский бульвар, дом 59а.</p></bio><bio xml:lang="en"><p>Postgraduate</p><p>Department of Surgical Treatment of Glaucoma</p><p>59a Beskudnikovsky Boulevard, Moscow, 127486</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Старостина</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Starostina</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук, младший научный сотрудник</p><p>Отдел хирургического лечения глаукомы</p><p>127486, Москва, Бескудниковский бульвар, дом 59а.</p></bio><bio xml:lang="en"><p>Ph.D., Junior Research Associate</p><p>Department of Surgical Treatment of Glaucoma</p><p>59a Beskudnikovsky Boulevard, Moscow, 127486</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАУ «НМИЦ «МНТК «Микрохирургия глаза» им. акад. С.Н. Федорова» Минздрава РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>S. Fyodorov Eye Microsurgery Federal State Institution</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>10</day><month>10</month><year>2020</year></pub-date><volume>19</volume><issue>2</issue><fpage>76</fpage><lpage>87</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ходжаев Н.С., Сидорова А.В., Смирнова Е.А., Елисеева М.А., Старостина А.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Ходжаев Н.С., Сидорова А.В., Смирнова Е.А., Елисеева М.А., Старостина А.В.</copyright-holder><copyright-holder xml:lang="en">Khodzhaev N.S., Sidorova A.V., Smirnova E.A., Eliseeva M.A., Starostina A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.glaucomajournal.ru/jour/article/view/300">https://www.glaucomajournal.ru/jour/article/view/300</self-uri><abstract><p>Неоваскулярная глаукома является тяжелой патологией органа зрения, которая трудно поддается медикаментозному и хирургическому лечению. Данная форма глаукомы характеризуется быстрым прогрессированием, высоким уровнем внутриглазного давления, выраженным болевым синдромом и снижением зрительных функций вплоть до полной их утраты. Наиболее частыми состояниями, при которых развивается неоваскулярная глаукома, являются диабетическая ретинопатия и тромбоз центральной вены сетчатки. Эндотелиальные клетки сосудов в ответ на специфический стимул в виде гипоксии вырабатывают проангиогенные факторы, наиболее значимым из которых является VEGF. Возникающий дисбаланс между про- и антиангиогенными факторами провоцирует развитие неоваскуляризации структур глаза. С целью уменьшения неоваскуляризации и снижения осложнений хирургического лечения применяются панретинальная лазеркоагуляция и введение анти-VEGF препаратов. В настоящее время для лечения неоваскулярной глаукомы применяются такие хирургические методы, как трабекулэктомия и имплантация трубчатых дренажей. Альтернативой хирургическим вмешательствам являются циклодеструктивные вмешательства. Новой технологией, характеризующейся отсутствием выраженного повреждающего действия на ткани и малым количеством осложнений, является транссклеральная циклофотокоагуляция в микроимпульсном режиме с использованием диодного лазера.</p></abstract><trans-abstract xml:lang="en"><p>Neovascular glaucoma is a severe pathology of the eye, which is difficult to treat. It is characterized by rapid progression, high intraocular pressure (IOP) level, severe pain and an acute decrease in visual acuity. Its most common causes include diabetic retinopathy and ischemic central retinal vein occlusion. The endothelial vascular cells respond to a specific stimulus (tissular hypoxia) and secrete proangiogenic factors. The most significant is VEGF. The resulting imbalance between pro- and antiangiogenic factors produces neovascularization of the eye tissues. Panretinal photocoagulation and anti-VEGF therapy are used to reduce iris neovascularization and reduce the complications of surgical treatment. Currently, surgical methods such as trabeculectomy and tubular drainage implantation are used to treat neovascular glaucoma. An alternative to surgical interventions is presented by cyclodestructive procedures. Transscleral diode-laser micropulse cyclophotocoagulation is the latest technology, characterized by the absence of a pronounced damaging effect on tissues and a small number of complications.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>неоваскулярная глаукома</kwd><kwd>анти-VEGF препараты</kwd><kwd>PEDF-фактор</kwd><kwd>микроимпульсная циклофотокоагуляция</kwd><kwd>обзор литературы</kwd><kwd>эффективность</kwd><kwd>безопасность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>neovascular glaucoma</kwd><kwd>anti-VEGF therapy</kwd><kwd>PEDF factor</kwd><kwd>micropulse cyclophotocoagulation</kwd><kwd>literature review</kwd><kwd>efficacy</kwd><kwd>safety</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Browning D.J. Retinal vein occlusions. Evidence-based management. 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