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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">glaucoma</journal-id><journal-title-group><journal-title xml:lang="ru">Национальный журнал Глаукома</journal-title><trans-title-group xml:lang="en"><trans-title>National Journal glaucoma</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-4104</issn><issn pub-type="epub">2311-6862</issn><publisher><publisher-name>Federal State Budgetary Institution of Science “Krasnov Research Institute of Eye Diseases”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.53432/2078-4104-2021-20-4-45-49</article-id><article-id custom-type="elpub" pub-id-type="custom">glaucoma-356</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Офтальмогипертензия, ассоциированная с увеальной меланомой. Причины диагностических ошибок</article-title><trans-title-group xml:lang="en"><trans-title>Ophthalmic hypertension associated with uveal melanoma. Causes of diagnostic errors</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гришина</surname><given-names>Е. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Grishina</surname><given-names>E. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гришина Е.Е., д.м.н., профессор, главный научный сотрудник офтальмологического отделения</p><p>129110, Москва, ул. Щепкина, 61/2-11</p></bio><bio xml:lang="en"><p>Grishina E.E., Dr. Sci. (Med.), Professor, Chief Researcher at the Ophthalmology Department</p><p>61/2 Schepkina St., Moscow, 129110</p></bio><email xlink:type="simple">eyelena@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Богатырев</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Bogatyrev</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Богатырев А.М., младший научный сотрудник офтальмологического отделения</p><p>129110, Москва, ул. Щепкина, 61/2-11</p></bio><bio xml:lang="en"><p>Bogatyrev A.M., Junior Researcher at the Ophthalmology Department</p><p>61/2 Schepkina St., Moscow, 129110</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лоскутов</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Loskutov</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лоскутов И.А., д.м.н., профессор кафедры офтальмологии и оптометрии, руководитель офтальмологического отделения</p><p>129110, Москва, ул. Щепкина, 61/2-11</p></bio><bio xml:lang="en"><p>Loskutov I.A., Dr. Sci. (Med.), Professor at the Academic Department of Ophthalmology and Optometry, Head of the Ophthalmology Department</p><p>61/2 Schepkina St., Moscow, 129110</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ МО Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского (МОНИКИ)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Regional Research and Clinical Institute ("MONIKI")</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>20</day><month>12</month><year>2021</year></pub-date><volume>20</volume><issue>4</issue><fpage>45</fpage><lpage>49</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гришина Е.Е., Богатырев А.М., Лоскутов И.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Гришина Е.Е., Богатырев А.М., Лоскутов И.А.</copyright-holder><copyright-holder xml:lang="en">Grishina E.E., Bogatyrev A.M., Loskutov I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.glaucomajournal.ru/jour/article/view/356">https://www.glaucomajournal.ru/jour/article/view/356</self-uri><abstract><sec><title>ЦЕЛЬ</title><p>ЦЕЛЬ. Выявить особенности клинического течения увеальной меланомы (УМ) с повышением внутриглазного давления (ВГД).</p></sec><sec><title>МЕТОДЫ</title><p>МЕТОДЫ. Ретроспективно проанализированы истории болезни 84 больных, получивших радикальное (ликвидационное) хирургическое лечение (энуклеация или экзентерация) по поводу УМ стадии T3–T4 в офтальмологическом отделении МОНИКИ с 2015 г. по 2020 г.</p></sec><sec><title>РЕЗУЛЬТАТЫ</title><p>РЕЗУЛЬТАТЫ. Поступившие для ликвидационной терапии УМ пациенты имели опухоль в стадии Т3 (80–95%) и в стадии Т4 (4–5%). Почти у трети больных (у 25 из 84 больных) при первичном обращении к офтальмологу было выявлено повышение ВГД от 30 до 50 мм рт.ст (в среднем 37,57 мм рт.ст.). В лечебных учреждениях по месту жительства двум пациентам была проведена антиглаукомная операция. Время ожидания с момента появления первых жалоб до поступления на лечение к офтальмоонкологу составило от 1 месяца до 18 месяцев (медиана 3,5 месяца). В связи с поздним выявлением УМ четыре пациента были направлены к офтальмоонкологу только после факоэмульсификации катаракты. Диагноз УМ был подтвержден гистологическим исследованием удаленного глазного яблока. Интересно отметить, что у всех пациентов с повышением ВГД выявлялись пигментированные формы меланомы.</p></sec><sec><title>ЗАКЛЮЧЕНИЕ</title><p>ЗАКЛЮЧЕНИЕ. При первичном обследовании пациента с повышением ВГД должна присутствовать онконастороженность. Особое внимание следует обращать на локальное расширение эпибульбарных сосудов, отграниченное затемнение склеры при трансиллюминации, необычную пигментацию радужки и угла передней камеры. Всем пациентам с впервые выявленной глаукомой целесообразно проводить ультразвуковое исследование глаза, при показаниях — ультразвуковую биометрию переднего отрезка глаза.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>PURPOSE</title><p>PURPOSE. To reveal the features of the clinical course of uveal melanoma with elevated intraocular pressure (IOP).</p></sec><sec><title>METHODS</title><p>METHODS. The study retrospectively analyses case histories of 84 patients who received radical (liquidation) surgical treatment (enucleation or exenteration) for stage T3–T4 uveal melanoma in the ophthalmology department of MONIKI from 2015 to 2020.</p></sec><sec><title>RESULTS</title><p>RESULTS. The patients admitted for liquidation therapy of uveal melanoma had a stage T3 tumor (80–95%) and stage T4 tumor (4–5%). In almost a third of patients (in 25 out of 84 patients), an increase in IOP from 30 to 50 mm Hg (in average 37.57 mm Hg) was detected during the initial ophthalmologist visit. Two patients underwent antiglaucoma surgery in medical institutions at the place of residence. The waiting time from the appearance of first complaints to admission for treatment at an ophthalmic-oncologist ranged from 1 month to 18 months (median 3.5 months). Due to the late detection of uveal melanoma, four patients were referred to an ophthalmic-oncologist only after cataract phacoemulsification. The diagnosis of uveal melanoma was confirmed by histological examination of the enucleated eye. It is worth noting that pigmented forms of melanoma were detected in all patients with elevated IOP.</p></sec><sec><title>CONCLUSION</title><p>CONCLUSION. The initial examination of a patient with elevated IOP should involve special attention to possible intraocular tumors. Particular attention should be paid to the local expansion of the epibulbar vessels, delimited darkening of the sclera during transillumination, unusual pigmentation of the iris and anterior chamber angle. A thorough examination of the paired eye is of great importance. It is advisable for all patients with newly diagnosed glaucoma to undergo an ultrasound examination of the eye, and if indicated — ultrasound biometry of the anterior segment of the eye.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>офтальмогипертензия</kwd><kwd>внутриглазное давление</kwd><kwd>увеальная меланома</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ophthalmic hypertension</kwd><kwd>intraocular pressure</kwd><kwd>uveal melanoma</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Офтальмоонкология. Под ред. Бровкиной А.Ф. Москва: Медицина 2002; 424.</mixed-citation><mixed-citation xml:lang="en">Oftal’moonkologiya [Ophthalmooncology]. Edited by Brovkina A.F. Moscow, Meditsina Publ., 2002. 424 p. 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