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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">glaucoma</journal-id><journal-title-group><journal-title xml:lang="ru">Национальный журнал Глаукома</journal-title><trans-title-group xml:lang="en"><trans-title>National Journal glaucoma</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-4104</issn><issn pub-type="epub">2311-6862</issn><publisher><publisher-name>Federal State Budgetary Institution of Science “Krasnov Research Institute of Eye Diseases”</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">glaucoma-360</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Исследование роли хориоидеи и хрусталика в развитии первичного закрытия угла передней камеры</article-title><trans-title-group xml:lang="en"><trans-title>Study of the role of chorioid and lens in the development of primary anterior chamber angle closure</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2265-6671</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Курышева</surname><given-names>Наталия Ивановна</given-names></name><name name-style="western" xml:lang="en"><surname>Kurysheva</surname><given-names>Natalia</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, заведующая кафедрой глазных болезней1, руководитель консультативно-диагностического отдела2</p></bio><bio xml:lang="en"><p>Doc. Sci. (Med.), Professor, Head of the Ophthalmology Department1</p><p> Head of the Consultative and Diagnostic Department2</p></bio><email xlink:type="simple">e-natalia@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7163-4858</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шарова</surname><given-names>Галина Аркадьевна</given-names></name><name name-style="western" xml:lang="en"><surname>Sharova</surname><given-names>Galina</given-names></name></name-alternatives><bio xml:lang="ru"><p>заведующая диагностическим офтальмологическим отделением, лазерный хирург</p></bio><bio xml:lang="en"><p>Head of the Diagnostic Ophthalmology Department, laser surgeon</p></bio><email xlink:type="simple">galina.shar@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9646-4747</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Беликова</surname><given-names>Елена Ивановна</given-names></name><name name-style="western" xml:lang="en"><surname>Belikova</surname><given-names>Elena</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., доцент, профессор кафедры офтальмологии1,</p><p>заместитель генерального директора по науке2</p></bio><bio xml:lang="en"><p>Associate Professor, Professor of Ophthalmology Department1</p><p>General Director Deputy of Science2</p></bio><email xlink:type="simple">docbelikova@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>1 Медико‐биологический университет инноваций и непрерывного образования ФГБУ ГНЦ РФ «Федеральный биофизический центр им. А.И. Бурназяна» ФМБА России, 123098, Российская Федерация, Москва, ул. Живописная, д. 46, корп. 8;&#13;
2 Консультативно-диагностический отдел Центра офтальмологии ФМБА России, ФГБУ ГНЦ РФ «ФМБЦ им. А.И. Бурназяна» ФМБА, 123098, Российская Федерация, Москва, ул. Гамалеи, 15.</institution><country>Россия</country></aff><aff xml:lang="en"><institution>1. The Department of Eye Diseases at the Medical Biological University of Innovations and Continuing Education of the Federal Biophysical Center named after A.I. Burnazyan, Zhivopisnaya str. 46, building 8, Moscow, Russian Federation, 123098;&#13;
2. Diagnostic Department of the Ophthalmological Center of Federal Medical‐Biological Agency of Russia, Gamalei str. 15, Moscow, Russian Federation, 123098;</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ООО "Глазная клиника доктора Беликовой",105118, Российская Федерация, Москва, пр. Буденного, 26 кор. 2.</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ophthalmology Clinic of Dr. Belikova, 26/2, Budenny Avenue, Moscow, Russian Federation, 105118</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>1. Академия постдипломного образования ФГБОУ ФНКЦ ФМБА России, Москва, 125371, Российская Федерация, Москва, Волоколамское ш., д. 91&#13;
2. ООО «Глазная клиника доктора Беликовой», 105118, Российская Федерация, Москва, пр. Буденного, 26 кор. 2.</institution><country>Россия</country></aff><aff xml:lang="en"><institution>1. Advanced Training Academy of Federal Medical and Biological Agency, the Chair of Ophthalmology, 91, Volokolamsk Hgwy, Moscow, Russian Federation, 125371&#13;
2. Ophthalmology Clinic of Dr. Belikova, 26/2, Budenny Avenue, Moscow, Russian Federation, 105118</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>16</day><month>02</month><year>2023</year></pub-date><volume>21</volume><issue>1</issue><elocation-id>360</elocation-id><permissions><copyright-statement>Copyright &amp;#x00A9; Курышева Н.И., Шарова Г.А., Беликова Е.И., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Курышева Н.И., Шарова Г.А., Беликова Е.И.</copyright-holder><copyright-holder xml:lang="en">Kurysheva N., Sharova G., Belikova E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.glaucomajournal.ru/jour/article/view/360">https://www.glaucomajournal.ru/jour/article/view/360</self-uri><abstract><sec><title>ЦЕЛЬ</title><p>ЦЕЛЬ. Изучить роль хориоидеи и хрусталика в развитии первичного закрытия угла передней камеры.</p></sec><sec><title>МАТЕРИАЛ И МЕТОДЫ</title><p>МАТЕРИАЛ И МЕТОДЫ. Исследование включало 90 пациентов (30 – с первичным закрытием угла (ПЗУ), 30 – с подозрением на первичное закрытие угла (ППЗУ), 30 – контроль) в возрасте от 47 до 80 лет, которым проведена оптическая когерентная томография Swept Source (SS-OCT). Анализируемые параметры: толщина субфовеолярной хориоидеи (ТХф), внутриглазное давление (ВГД), аксиальная длина глаза (AL), глубина передней камеры (ACD), высота свода хрусталика (LV), кривизна радужки (ICurv) и ее толщина (IT750), дистанция открытия угла (AOD500, AOD750), иридотрабекулярное пространство (TISA500, TISA750).</p></sec><sec><title>РЕЗУЛЬТАТЫ</title><p>РЕЗУЛЬТАТЫ. ТХф при ПЗУ (341±59 мкм) и ППЗУ (340±51 мкм), была выше, чем в контроле (257,0±37,0 мкм, p&lt;0,05). При ПЗУ и ППЗУ выявлены корреляции ТХф с возрастом, AL, LV, ICurv, IT750 (все p&lt;0,05), а также установлены корреляции LV с возрастом, ВГД, ACD, ICurv, IT750, AOD500, AOD750, TISA500, TISA750 (все p&lt;0,05). Только при ПЗУ отмечалась корреляция ТХф с ВГД (p=-0,476; p=0,008).</p></sec><sec><title>ЗАКЛЮЧЕНИЕ</title><p>ЗАКЛЮЧЕНИЕ. Увеличение толщины хориоидеи в макуле по сравнению с контролем как при ППЗУ, так и при ПЗУ, а также корреляции субфовеолярной хориоидеи с высотой свода хрусталика и параметрами радужки предполагают участие хориоидеи в патогенезе заболевания первичного закрытия угла (ЗПЗУ). Корреляции высоты свода хрусталика с ВГД, параметрами передней камеры и радужки свидетельствуют о доминирующей роли хрусталика в формировании ЗПЗУ и необходимости ранней его замены.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>PURPOSE</title><p>PURPOSE. To study the role of the choroid and lens in the development of primary anterior chamber angle closure.</p></sec><sec><title>MATERIAL AND METHODS</title><p>MATERIAL AND METHODS. The study included 90 patients aged 47 to 80 (30 with primary angle closure (PAC), 30 with suspected primary angle closure (PACs), and 30 in the control group) who underwent swept source optical coherence tomography (SS-OCT). The following parameters were analyzed: subfoveolar choroidal thickness (SFCT), intraocular pressure (IOP), axial length (AL), anterior chamber depth (ACD), lens vault (LV), iris curvature (ICurv) and iris thickness (IT750), angle opening distance (AOD500, AOD750), and iridotrabecular space (TISA500, TISA750).</p></sec><sec><title>RESULTS</title><p>RESULTS. SFCT in PAC (341±59 µm) and PACs (340±51 µm) was higher than in the control group (257.0±37.0 µm, p&lt;0.05). In PAC and PACs, the correlations of SFCT with age, AL, LV, ICurv, IT750 were revealed (all p&lt;0.05). Also, in PAC and PACs, the correlations of LV with age, IOP, ACD, ICurv, IT750, AOD500, AOD750, TISA500, TISA750 were found (all p&lt;0.05). Only in PAC the correlation of SFCT with IOP was determined (p=-0.476; p=0.008).</p></sec><sec><title>CONCLUSION</title><p>CONCLUSION. The increase in the choroidal thickness in macula compared with the control in both PACs and PAC, as well as the correlations of subfoveolar choroidal thickness with lens vault and iris parameters, suggest the involvement of the choroid in the pathogenesis of primary angle closure disease (PACD). The correlations of lens vault with IOP, the anterior chamber parameters and iris indicate the prevailing role of the lens in the development of PACD and the need for its early replacement.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>первичное закрытие угла передней камеры</kwd><kwd>SS-OCT</kwd><kwd>толщина хориоидеи</kwd><kwd>передняя камера и хрусталик.</kwd></kwd-group><kwd-group xml:lang="en"><kwd>primary angle closure</kwd><kwd>SS-OCT</kwd><kwd>choroidal thickness</kwd><kwd>anterior chamber and lens</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Quigley HA. What's the choroid got to do with angle closure?. Arch Ophthalmol. 2009;127(5):693–694. doi.org/10.1001/archophthalmol.2009.80</mixed-citation><mixed-citation xml:lang="en">Quigley HA. What's the choroid got to do with angle closure?. 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