glaucomaНациональный журнал ГлаукомаNational Journal glaucoma2078-41042311-6862Federal State Budgetary Institution of Science “Krasnov Research Institute of Eye Diseases”glaucoma-404Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESАнатомо-топографические особенности переднего и заднего сегментов глаза при ранних стадиях заболевания первичного закрытия углаAnatomo-topographical characteristics of the eye in the early stages of primary angle closure diseasehttps://orcid.org/0000-0002-2265-6671КурышеваНаталия ИвановнаKuryshevaNatalia

д.м.н., профессор, заведующая кафедрой глазных болезней1,

руководитель консультативно-диагностического отдела2;

Doc. Sci. (Med.), Professor, Head of the Ophthalmology Department1

 

, Head of the Consultative and Diagnostic Department2

e-natalia@list.ruhttps://orcid.org/0000-0002-7163-4858ШароваГалина АркадьевнаSharovaGalina

заведующая диагностическим офтальмологическим отделение

SPIN-РИНЦ 7067-0326

 

 

Head of the Diagnostic Ophthalmology DepartmenSPIN-РИНЦ 7067-0326 

 

galina.shar@mail.ru1. Медико‐биологический университет инноваций и непрерывного образования ФГБУ ГНЦ РФ «Федеральный биофизический центр им. А.И. Бурназяна» ФМБА России, 123098, Российская Федерация, Москва, ул. Живописная, д. 46, корп. 8; 2. Консультативно-диагностический отдел Центра офтальмологии ФМБА России, ФГБУ ГНЦ РФ «ФМБЦ им. А.И. Бурназяна» ФМБА, 123098, Российская Федерация, Москва, ул. Гамалеи, 15;Россия1. The Department of Eye Diseases at the Medical Biological University of Innovations and Continuing Education of the Federal Biophysical Center named after A.I. Burnazyan, Zhivopisnaya str. 46, building 8, Moscow, Russian Federation, 123098; 2. Diagnostic Department of the Ophthalmological Center of Federal Medical‐Biological Agency of Russia, Gamalei str. 15, Moscow, Russian Federation, 123098;Russian FederationООО "Глазная клиника доктора Беликовой"105118, Российская Федерация, Москва, пр. Буденного, 26 кор. 2;РоссияOphthalmology Clinic of Dr. Belikova 26/2, Budenny Avenue, Moscow, Russian Federation, 105118;Russian Federation202318042023221404Copyright © Курышева Н.И., Шарова Г.А., 20232023Курышева Н.И., Шарова Г.А.Kurysheva N., Sharova G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.glaucomajournal.ru/jour/article/view/404ЦЕЛЬ

ЦЕЛЬ. Определить анатомо-топографические особенности переднего и заднего сегментов глаза при первичном закрытии угла (ПЗУ) и сравнить их с таковыми при подозрении на первичное закрытие угла (ППЗУ) и в контроле.

МАТЕРИАЛ И МЕТОДЫ

МАТЕРИАЛ И МЕТОДЫ. Проспективное исследование включало 120 пациентов от 41 до 80 лет (60 глаз – ПЗУ, 30 – ППЗУ, 30 глаз – без офтальмопатологии). Исследуемые параметры включали: сфероэквивалент (СЭ), внутриглазное давление (ВГД), толщину хориоидеи в фовеоле (ТХф), аксиальную длину (AL), глубину передней камеры (ACD), высоту свода хрусталика (LV), кривизну радужки и ее толщину, профиль угла передней камеры (УПК): AOD500, AOD750, TISA500, TISA750.

РЕЗУЛЬТАТЫ

РЕЗУЛЬТАТЫ. ППЗУ отличалась от контроля увеличенными СЭ, LV, ВГД, кривизной радужки, ТХф, уменьшенными ACD, AL, и профилем УПК (AOD500, AOD750, TISA500, TISA750) в вертикальных секторах (все p<0,01), по толщине радужки группы были сопоставимы. ПЗУ отличалась от ППЗУ увеличенными СЭ, LV, ВГД, уменьшенными ACD, AL, AOD500 в верхнем секторе и профилем УПК в нижнем секторе (все p<0,01). Толщина радужки и ее кривизна, а также профиль УПК в верхнем секторе и ТХф были сопоставимы. Определены пороговые значения, отличающие ППЗУ и ПЗУ: LV – 0,656 мм, AOD500 – 0,131 мм, TISA500 – 0,051 мм2, TISA750 – 0,093 мм2 в нижнем секторе, ВГД 21 мм рт.ст. В многофакторной модели с поправками на возраст, пол и AL установлена обратная взаимосвязь толщины радужки с ТХф как при ППЗУ, так и при ПЗУ (все p<0,01), но не в контроле (все p>0,01).

ЗАКЛЮЧЕНИЕ

ЗАКЛЮЧЕНИЕ. Параметры ЗПЗУ достоверно отличаются от нормы. LV и профиль УПК в нижнем секторе наиболее информативны в дифференциальной диагностике ППЗУ и ПЗУ. Обратная взаимосвязь толщины радужки и хориоидеи позволяет предположить роль сосудистой оболочки в патогенезе ЗПЗУ.

Purpose

Purpose. To determine the anatomical and topographic features of the anterior and posterior segments of the eye in the primary angle closure (PAC) and compare them with those in the primary angle closure suspects (PACs) and in control.

MATERIAL AND METHODS

MATERIAL AND METHODS. The prospective study included 120 patients aged 41 to 80 years (60 eyes – PAC, 30 – PACs, 30 eyes – without ophthalmopathology). The studied parameters included: spheroequivalent (SE), intraocular pressure (IOP), choroidal thickness in the fovea (CTf), axial length (AL), anterior chamber depth (ACD), lens volume (LV), iris curvature and its thickness, anterior chamber angle profile of anterior chamber: AOD500, AOD750, TISA500, TISA750.

RESULTS

RESULTS. The PAC eyes differed from the control eyes by increased SE, LV, IOP, iris curvature, CTf, reduced ACD, AL, and the profile of the anterior chamber (AOD500, AOD750, TISA500, TISA750) in vertical sectors (p<0.01). The iris thickness in the groups was comparable. The PAC eyes differed from the PACs by increased SE, LV, IOP, reduced ACD, AL, AOD500 in the upper sector, and the parameters characterized the profile of the anterior chamber in the lower sector (p<0.01). The iris thickness, its curvature, as well as the profile of the anterior chamber in the upper sector and the CTf were comparable. Threshold values that distinguish the PAC and PACs were determined: LV – 0.656 mm, AOD500 – 0.131 mm, TISA500 – 0.051 mm2, TISA750 – 0.093 mm2 in the lower sector and IOP 21 mm Hg. In the multifactor model, adjusted for age, gender and AL, the inverse relationship of iris thickness with CTf was established both in PAC and with PACs (all p<0.01), but not in control (all p>0.01).

CONCLUSION

CONCLUSION. The parameters of PAC and PACs eyes significantly differ from the norm. LV and the profile of the anterior chamber in the lower sector are the most informative in the differentiating the PAC eyes from PACs. The inverse relationship between the iris and choroidal thickness suggests the role of the choroid in the pathogenesis of primary angle closure disease.

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The authors declare that there are no conflicts of interest present.