<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">glaucoma</journal-id><journal-title-group><journal-title xml:lang="ru">Национальный журнал Глаукома</journal-title><trans-title-group xml:lang="en"><trans-title>National Journal glaucoma</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-4104</issn><issn pub-type="epub">2311-6862</issn><publisher><publisher-name>Federal State Budgetary Institution of Science “Krasnov Research Institute of Eye Diseases”</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">glaucoma-410</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Глаукома у беременных: особенности лечения.</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7790-6968</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юрлагина</surname><given-names>Арина Валерьевна</given-names></name></name-alternatives><bio xml:lang="ru"><p>ординатор </p></bio><email xlink:type="simple">gabaydulina.arina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГБОУ ВО Омский государственный медицинский университет Минздрава России</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>18</day><month>04</month><year>2023</year></pub-date><volume>22</volume><issue>1</issue><elocation-id>410</elocation-id><permissions><copyright-statement>Copyright &amp;#x00A9; Юрлагина А.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Юрлагина А.В.</copyright-holder><copyright-holder xml:lang="en">Юрлагина А.В.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.glaucomajournal.ru/jour/article/view/410">https://www.glaucomajournal.ru/jour/article/view/410</self-uri><abstract><p>В данном обзоре представлена информация об особенностях, частоте встречаемости, патогенетическом механизме, вариантах консервативного, лазерного и хирургического лечения глаукомы у беременных. Цель работы: изучить на основе актуальной информации особенности ведения пациенток с глаукомой в период беременности. Глаукома – большая группа заболеваний глаза, характеризующаяся прогрессирующим снижением зрения вплоть до потери зрительных функций и атрофии зрительного нерва. Патология наиболее распространена среди населения старше 40 лет, но в связи с достижениями в области репродуктивных технологий, доступностью диагностических методик, высокой клинической осведомленностью увеличивается вероятность ведения глаукомы у беременных женщин офтальмологами. Повышенное внутриглазное давление у беременных становится все более часто встречаемой и, следовательно, актуальной проблемой. Наблюдается тенденция к увеличению числа беременных женщин, впервые столкнувшихся с повышением внутриглазного давления. К особенной категории пациентов относится уже выявленная патология в детском возрасте или же глаукома вторичная вследствие перенесенных ранее офтальмологических заболеваний или тяжелой соматической патологии. Все перечисленные категории встречаются в настоящее время и требуют тщательного мониторинга со стороны как офтальмолога, так и акушера-гинеколога. Доказательная база по антиглаукомным препаратам незначительна, имеются клинические эксперименты на животных, результаты которых не всегда можно переносить на человека и ретроспективные исследования. В арсенале врача на данный момент имеется ряд препаратов, имеющих возможные побочные действия для плода, лазерное и хирургическое лечение. Стандартов оказания помощи не существует, поэтому каждый случай должен рассматриваться индивидуально с пониманием физиологии, механизма действия препаратов и их возможными эффектами. Таким образом, глаукома во время беременности и в период лактации представляет серьезную медицинскую проблему, решение которой лежит в плоскости междисциплинарной медицины.</p></abstract><kwd-group xml:lang="ru"><kwd>внутриглазное давление</kwd><kwd>глаукома: беременность и глаукома</kwd><kwd>антиглаукомные препараты.</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">· Marx-Gross S., Laubert-Reh D., Schneider A., Höhn R., Mirshahi A., Münzel T., Wild P.S., Beutel M.E., Blettner M., Pfeiffer N. The prevalence of glaucoma in young people. Dtsch. Arztebl. Int. 2017;114:204–210.DOI: 10.3238/arztebl.2017.0204</mixed-citation><mixed-citation xml:lang="en">·	Marx-Gross S., Laubert-Reh D., Schneider A., Höhn R., Mirshahi A., Münzel T., Wild P.S., Beutel M.E., Blettner M., Pfeiffer N. The prevalence of glaucoma in young people. Dtsch. Arztebl. Int. 2017;114:204–210.DOI: 10.3238/arztebl.2017.0204</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">· Mathew S., Harris A., Ridenour C.M.,et al Management of glaucoma in pregnancy. J. Glaucoma. 2019;28:937–944. DOI: 10.1097/IJG.0000000000001456</mixed-citation><mixed-citation xml:lang="en">·	Mathew S., Harris A., Ridenour C.M.,et al Management of glaucoma in pregnancy. J. Glaucoma. 2019;28:937–944.DOI: 10.1097/IJG.0000000000001456</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">· Strelow B., Fleischman D. Glaucoma in pregnancy: An update. Curr. Opin. Ophthalmol. 2020;31:114–122.DOI: 10.1097/ICU.0000000000000641</mixed-citation><mixed-citation xml:lang="en">·	Strelow B., Fleischman D. Glaucoma in pregnancy: An update. Curr. Opin. Ophthalmol. 2020;31:114–122. DOI: 10.1097/ICU.0000000000000641</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Colãs-Tomãs T, López Tizón E. Ex-PRESS mini-shunt implanted in a pregnant patient with iridocorneal endothelial syndrome. Eur J Ophthalmol 2020; 30: NP25–NP28</mixed-citation><mixed-citation xml:lang="en">·	Colãs-Tomãs T, López Tizón E. Ex-PRESS mini-shunt implanted in a pregnant patient with iridocorneal endothelial syndrome. Eur J Ophthalmol 2020; 30: NP25–NP28. DOI: 10.1177/1120672118820508</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">· DOI: 10.1177/1120672118820508</mixed-citation><mixed-citation xml:lang="en">Razeghinejad MR, Masoumpour M, Eghbal MH, et al. Glaucoma surgery in pregnancy: A case series and literature review. Iran J Med Sci. 2016;41:437–45. doi. 27582594</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Razeghinejad MR, Masoumpour M, Eghbal MH, et al. Glaucoma surgery in pregnancy: A case series and literature review. Iran J Med Sci. 2016;41:437–45.doi. 27582594</mixed-citation><mixed-citation xml:lang="en">·	Tham Y-C, Li X, Wong TY, et al. Global prevalence of glaucoma and projections of glaucoma burden through 2040. Ophthalmology 2014; 121: 2081–2090.DOI: 10.1016/j.ophtha.2014.05.013</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">· Tham Y-C, Li X, Wong TY, et al. Global prevalence of glaucoma and projections of glaucoma burden through 2040. Ophthalmology 2014; 121: 2081–2090. DOI: 10.1016/j.ophtha.2014.05.013</mixed-citation><mixed-citation xml:lang="en">·	Vaideanu D, Fraser S. Glaucoma management in pregnancy: A questionnaire survey. Eye. 2007;21:341–3. DOI: 10.1038/sj.eye.6702193</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">· Vaideanu D, Fraser S. Glaucoma management in pregnancy: A questionnaire survey. Eye. 2007;21:341–3. DOI: 10.1038/sj.eye.6702193</mixed-citation><mixed-citation xml:lang="en">·	Kapetanakis V, Chan MP, Foster PJ, et al. Global variations and time trends in the prevalence of primary open angle glaucoma (POAG): a systematic review and meta-analysis. Br J Ophthalmol. 2016; 100: 86–93. DOI: 10.1136/bjophthalmol-2015-307223</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">· Kapetanakis V, Chan MP, Foster PJ, et al. Global variations and time trends in the prevalence of primary open angle glaucoma (POAG): a systematic review and meta-analysis. Br J Ophthalmol. 2016; 100: 86–93.DOI: 10.1136/bjophthalmol-2015-307223</mixed-citation><mixed-citation xml:lang="en">Green K., Phillips C.I., Cheeks L., Slagle T. Aqueous humor flow rate and intraocular pressure during and after pregnancy. Ophthalmic Res. 1988;20:353–357. doi: 10.1159/000266751.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Green K., Phillips C.I., Cheeks L., Slagle T. Aqueous humor flow rate and intraocular pressure during and after pregnancy. Ophthalmic Res. 1988;20:353–357. doi: 10.1159/000266751.</mixed-citation><mixed-citation xml:lang="en">·	Wang C., Li A.L., Pang Y., Lei Y.Q., Yu L. Changes in intraocular pressure and central corneal thickness during pregnancy: A systematic review and Meta-analysis. Int. J. Ophthalmol. 2017;10:1573–1579. DOI: 10.18240/ijo.2017.10.15</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">· Wang C., Li A.L., Pang Y., Lei Y.Q., Yu L. Changes in intraocular pressure and central corneal thickness during pregnancy: A systematic review and Meta-analysis. Int. J. Ophthalmol. 2017;10:1573–1579. DOI: 10.18240/ijo.2017.10.15</mixed-citation><mixed-citation xml:lang="en">Akar Y., Yucel I., Akar M.E., Zorlu G., Ari E.S. Effect of pregnancy on intraobserver and intertechnique agreement in intraocular pressure measurements. Ophthalmologica. 2005;219:36–42. doi: 10.1159/000081781</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Akar Y., Yucel I., Akar M.E., Zorlu G., Ari E.S. Effect of pregnancy on intraobserver and intertechnique agreement in intraocular pressure measurements. Ophthalmologica. 2005;219:36–42. doi: 10.1159/000081781</mixed-citation><mixed-citation xml:lang="en">Qureshi I.A., Xi X.R., Yaqob T. The ocular hypotensive effect of late pregnancy is higher in multigravidae than in primigravidae. Graefes. Arch. Clin. Exp. Ophthalmol. 2000;238:64–67. doi: 10.1007/s004170050011</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Qureshi I.A., Xi X.R., Yaqob T. The ocular hypotensive effect of late pregnancy is higher in multigravidae than in primigravidae. Graefes. Arch. Clin. Exp. Ophthalmol. 2000;238:64–67. doi: 10.1007/s004170050011</mixed-citation><mixed-citation xml:lang="en">·	Tolunay HE, Özcan SC, Şükür YE, et al. Changes of intraocular pressure in different trimesters of pregnancy among Syrian refugees in Turkey: a cross-sectional study. Turk J Obstet Gynecol 2016; 13: 67–70. DOI: 10.4274/tjod.40221</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">· Tolunay HE, Özcan SC, Şükür YE, et al. Changes of intraocular pressure in different trimesters of pregnancy among Syrian refugees in Turkey: a cross-sectional study. Turk J Obstet Gynecol 2016; 13: 67–70. DOI: 10.4274/tjod.40221</mixed-citation><mixed-citation xml:lang="en">·	Kumari, Rashmi et al. “Management of glaucoma in pregnancy - balancing safety with efficacy.” Therapeutic advances in ophthalmology vol. 13 25158414211022876. 28 Jun. 2021. DOI: 10.1177/25158414211022876</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">· Kumari, Rashmi et al. “Management of glaucoma in pregnancy - balancing safety with efficacy.” Therapeutic advances in ophthalmology vol. 13 25158414211022876. 28 Jun. 2021. DOI: 10.1177/25158414211022876</mixed-citation><mixed-citation xml:lang="en">Paramjyothi P, Lakshmi ANR, Surekha D, et al. Physiological changes of intraocular pressure(IOP) in the second and third trimesters of normal pregnancy. J Clin Diagn Res 2011; 31: 364–366.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Paramjyothi P, Lakshmi ANR, Surekha D, et al. Physiological changes of intraocular pressure(IOP) in the second and third trimesters of normal pregnancy. J Clin Diagn Res 2011; 31: 364–366.</mixed-citation><mixed-citation xml:lang="en">Omoti AE, Waziri-Erameh JM, Okeigbemen VM. A review of the changes in the ophthalmic and visual system in pregnancy. Afr J Reprod Health 2008; 12: 185–196.PMID: 19435022</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">· Omoti AE, Waziri-Erameh JM, Okeigbemen VM. A review of the changes in the ophthalmic and visual system in pregnancy. Afr J Reprod Health 2008; 12: 185–196. PMID: 19435022</mixed-citation><mixed-citation xml:lang="en">·	Tehrani S. Gender difference in the pathophysiology and treatment of glaucoma. Curr Eye Res 2015; 40: 191–200.DOI: 10.3109/02713683.2014.968935</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">· Tehrani S. Gender difference in the pathophysiology and treatment of glaucoma. Curr Eye Res 2015; 40: 191–200.DOI: 10.3109/02713683.2014.968935</mixed-citation><mixed-citation xml:lang="en">·	Efe YK, Ugurbas SC, Alpay A, et al. The course of corneal and intraocular pressure during pregnancy. Can J Ophthalmol 2012; 47: 150–154.DOI: 10.1016/j.jcjo.2012.01.004</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">· Efe YK, Ugurbas SC, Alpay A, et al. The course of corneal and intraocular pressure during pregnancy. Can J Ophthalmol 2012; 47: 150–154.DOI: 10.1016/j.jcjo.2012.01.004</mixed-citation><mixed-citation xml:lang="en">·	Razeghinejad M.R., Tania Tai T.Y., Fudemberg S.J., Katz L.J. Pregnancy and glaucoma. Surv. Ophthalmol. 2011;56:324–335.DOI: 10.1016/j.survophthal.2010.11.008</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">· Razeghinejad M.R., Tania Tai T.Y., Fudemberg S.J., Katz L.J. Pregnancy and glaucoma. Surv. Ophthalmol. 2011;56:324–335. DOI: 10.1016/j.survophthal.2010.11.008</mixed-citation><mixed-citation xml:lang="en">·	Drake S.C., Vajaranant T.S. Evidence-based approaches to glaucoma management during pregnancy and lactation. Curr. Ophthalmol. Rep. 2016;4:198–205. DOI: 10.1007/s40135-016-0112-1</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">· Drake S.C., Vajaranant T.S. Evidence-based approaches to glaucoma management during pregnancy and lactation. Curr. Ophthalmol. Rep. 2016;4:198–205. DOI: 10.1007/s40135-016-0112-1</mixed-citation><mixed-citation xml:lang="en">·	Garg P, Aggarwal P. Ocular changes in pregnancy. Nepal J Ophthalmol 2012; 4: 150–161.DOI: 10.3126/nepjoph.v4i1.5867</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">· Garg P, Aggarwal P. Ocular changes in pregnancy. Nepal J Ophthalmol 2012; 4: 150–161.DOI: 10.3126/nepjoph.v4i1.5867</mixed-citation><mixed-citation xml:lang="en">·	Qureshi IA, Xi XR, Wu XD. Intraocular pressure trends in pregnancy and in the third trimester hypertensive patients. Acta Obstet Gynecol Scand 1996; 75: 816–819. DOI: 10.3109/00016349609054709</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">· Qureshi IA, Xi XR, Wu XD. Intraocular pressure trends in pregnancy and in the third trimester hypertensive patients. Acta Obstet Gynecol Scand 1996; 75: 816–819. DOI: 10.3109/00016349609054709</mixed-citation><mixed-citation xml:lang="en">·	Chawla S, Chaudhary T, Aggarwal S, et al. Ophthalmic considerations in pregnancy. Med J Armed Forces India 2013; 69: 278–284. DOI: 10.1016/j.mjafi.2013.03.006</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">· Chawla S, Chaudhary T, Aggarwal S, et al. Ophthalmic considerations in pregnancy. Med J Armed Forces India 2013; 69: 278–284. DOI: 10.1016/j.mjafi.2013.03.006</mixed-citation><mixed-citation xml:lang="en">Dima AM. Eye and the pregnacy. Oftalmologia 2012; 56: 20–26</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Dima AM. Eye and the pregnacy. Oftalmologia 2012; 56: 20–26</mixed-citation><mixed-citation xml:lang="en">·	Mendez-Hernandez C, Garcia-Feijoo J, Saenz-Frances F, et al. Topical intraocular pressure therapy effects on pregnancy. Clin Ophthalmol 2012; 6: 1629–1632.DOI: 10.2147/OPTH.S36712</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">· Mendez-Hernandez C, Garcia-Feijoo J, Saenz-Frances F, et al. Topical intraocular pressure therapy effects on pregnancy. Clin Ophthalmol 2012; 6: 1629–1632. DOI: 10.2147/OPTH.S36712</mixed-citation><mixed-citation xml:lang="en">Egorov E.A. et al. The International Guide to Glaucoma. Volume 2. Glaucoma clinic. Moscow – 2016. pp. 162-170</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Егоров Е.А. и др. Межнациональное руководство по глаукоме. Том 2. Клиника глаукомы. Москва – 2016. с. 162-170</mixed-citation><mixed-citation xml:lang="en">·	Coleman AL, Mosaed S, Kamal D. Medical therapy in pregnancy. J Glaucoma 2005; 14: 414–416.DOI: 10.1097/01.ijg.0000177214.39244.da</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">· Coleman AL, Mosaed S, Kamal D. Medical therapy in pregnancy. J Glaucoma 2005; 14: 414–416.DOI: 10.1097/01.ijg.0000177214.39244.da</mixed-citation><mixed-citation xml:lang="en">·	Maul H, Longo M, Saade G, et al. Nitric oxide and its role during pregnancy: from ovulation to delivery. Curr Pharm Des 2003; 9: 359–380. DOI: 10.2174/1381612033391784</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">· Maul H, Longo M, Saade G, et al. Nitric oxide and its role during pregnancy: from ovulation to delivery. Curr Pharm Des 2003; 9: 359–380. DOI: 10.2174/1381612033391784</mixed-citation><mixed-citation xml:lang="en">Zimmerman TJ, Kooner KS, Kandarakis AS, et al. Improving the therapeutic index of topically applied ocular drugs. Arch Ophthalmol 1984; 102: 551–553. DOI: 10.1001/archopht.1984.01040030429017</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">· Zimmerman TJ, Kooner KS, Kandarakis AS, et al. Improving the therapeutic index of topically applied ocular drugs. Arch Ophthalmol 1984; 102: 551–553. DOI: 10.1001/archopht.1984.01040030429017</mixed-citation><mixed-citation xml:lang="en">European Glaucoma Society. Terminology and guidelines for glaucoma, 4th Edition. Br J Ophthalmol 2017; 101: 1–195.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">European Glaucoma Society. Terminology and guidelines for glaucoma, 4th Edition. Br J Ophthalmol 2017; 101: 1–195.</mixed-citation><mixed-citation xml:lang="en">Law R, Bozzo P, Koren G, et al. FDA pregnancy risk categories and the CPS: do they help or are they a hindrance? Can Fam Physician 2010; 56: 239–241. doi: PMC2837687</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">· Law R, Bozzo P, Koren G, et al. FDA pregnancy risk categories and the CPS: do they help or are they a hindrance? Can Fam Physician 2010; 56: 239–241.doi: PMC2837687</mixed-citation><mixed-citation xml:lang="en">Coroi MC, Bungau S, Tit M. PRESERVATIVES FROM THE EYE DROPS AND THE OCULAR SURFACE. Rom J Ophthalmol. 2015 Jan-Mar;59(1):2-5. PMID: 27373107; PMCID: PMC5729814.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Coroi MC, Bungau S, Tit M. PRESERVATIVES FROM THE EYE DROPS AND THE OCULAR SURFACE. Rom J Ophthalmol. 2015 Jan-Mar;59(1):2-5. PMID: 27373107; PMCID: PMC5729814.</mixed-citation><mixed-citation xml:lang="en">·	da Silva Dal Pizzol T, Knop FP, Mengue SS. Prenatal exposure to misoprostol and congenital anomalies: systematic review and meta-analysis. Reprod Toxicol 2006; 22: 666–671.DOI: 10.1016/j.reprotox.2006.03.015</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">· da Silva Dal Pizzol T, Knop FP, Mengue SS. Prenatal exposure to misoprostol and congenital anomalies: systematic review and meta-analysis. Reprod Toxicol 2006; 22: 666–671.DOI: 10.1016/j.reprotox.2006.03.015</mixed-citation><mixed-citation xml:lang="en">Karim S.M. Physiological rôle of prostaglandins in the control of parturition and menstruation // J. Reprod. Fertil. Suppl. 1972. Vol. 16. Suppl. 16. P. 105–111.DOI: 10.1111/j.1749-6632.1971.tb53216.x</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">· Karim S.M. Physiological rôle of prostaglandins in the control of parturition and menstruation // J. Reprod. Fertil. Suppl. 1972. Vol. 16. Suppl. 16. P. 105–111.DOI: 10.1111/j.1749-6632.1971.tb53216.x</mixed-citation><mixed-citation xml:lang="en">·	Sideris E.B., Yokochi K., Coceani F., Olley P.M. Prostaglandins and fetal cardiac output distribution in the lamb // Am. J. Physiol. 1985. Vol. 248. № 6. Pt. 2. H853-8.DOI: 10.1152/ajpheart.1985.248.6.H853</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">· Sideris E.B., Yokochi K., Coceani F., Olley P.M. Prostaglandins and fetal cardiac output distribution in the lamb // Am. J. Physiol. 1985. Vol. 248. № 6. Pt. 2. H853-8.DOI: 10.1152/ajpheart.1985.248.6.H853</mixed-citation><mixed-citation xml:lang="en">·	Pellegrino M, D’Oria L, DeLuca C, et al. Glaucomadrugtherapy in pregnancy: literature review and teratology information service (TIS) case series. Curr Drug Saf 2018; 13: 3–11.DOI: 10.2174/1574886312666171030125804</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">· Pellegrino M, D’Oria L, DeLuca C, et al. Glaucomadrugtherapy in pregnancy: literature review and teratology information service (TIS) case series. Curr Drug Saf 2018; 13: 3–11.DOI: 10.2174/1574886312666171030125804</mixed-citation><mixed-citation xml:lang="en">·	De Santis M., Lucchese A., Carducci B. et al. Latanoprost exposure in pregnancy // Am. J. Ophthalmol. 2004. Vol. 138. № 2. P. 305–306.DOI: 10.1016/j.ajo.2004.03.002</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">· De Santis M., Lucchese A., Carducci B. et al. Latanoprost exposure in pregnancy // Am. J. Ophthalmol. 2004. Vol. 138. № 2. P. 305–306.DOI: 10.1016/j.ajo.2004.03.002</mixed-citation><mixed-citation xml:lang="en">·	Printz M.P., Skidgel R.A., Friedman W.F. Studies of pulmonary prostaglandin biosynthetic and catabolic enzymes as factors in ductus arteriosus patency and closure. Evidence for a shift in products with gestational age // Pediatr. Res. 1984. Vol. 18. № 1. P. 19–24.PMID: 6422431</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">· Printz M.P., Skidgel R.A., Friedman W.F. Studies of pulmonary prostaglandin biosynthetic and catabolic enzymes as factors in ductus arteriosus patency and closure. Evidence for a shift in products with gestational age // Pediatr. Res. 1984. Vol. 18. № 1. P. 19–24.PMID: 6422431</mixed-citation><mixed-citation xml:lang="en">Bausch + Lomb. VYZULTA (latanoprostene bunod ophthalmic solution) 0.024% [package insert]. Silver Spring, MD: US Food and Drug Administration, 2017</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Bausch + Lomb. VYZULTA (latanoprostene bunod ophthalmic solution) 0.024% [package insert]. Silver Spring, MD: US Food and Drug Administration, 2017</mixed-citation><mixed-citation xml:lang="en">·	Hoy SM. Latanoprostene Bunod Ophthalmic Solution 0.024%: a review in open- angle glaucoma and ocular hypertension. Drugs 2018; 78: 773–780.DOI: 10.1007/s40265-018-0914-6</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">· Hoy SM. Latanoprostene Bunod Ophthalmic Solution 0.024%: a review in open- angle glaucoma and ocular hypertension. Drugs 2018; 78: 773–780.DOI: 10.1007/s40265-018-0914-6</mixed-citation><mixed-citation xml:lang="en">·	Weinreb RN, Ong T, Scassellati Sforzolini B, et al. A randomised, controlled comparison of latanoprostene bunod and latanoprost 0.005% in the treatment of ocular hypertension and open angle glaucoma: the VOYAGER study. Br J Ophthalmol 2015; 99: 738–745.DOI: 10.1136/bjophthalmol-2014-305908</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">· Weinreb RN, Ong T, Scassellati Sforzolini B, et al. A randomised, controlled comparison of latanoprostene bunod and latanoprost 0.005% in the treatment of ocular hypertension and open angle glaucoma: the VOYAGER study. Br J Ophthalmol 2015; 99: 738–745.DOI: 10.1136/bjophthalmol-2014-305908</mixed-citation><mixed-citation xml:lang="en">·	Salim S. Glaucoma in pregnancy. Curr Opin Ophthalmol 2014; 25: 93–97.DOI: 10.1097/ICU.0000000000000029</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">· Salim S. Glaucoma in pregnancy. Curr Opin Ophthalmol 2014; 25: 93–97.DOI: 10.1097/ICU.0000000000000029</mixed-citation><mixed-citation xml:lang="en">Naderan M. Ocular changes during pregnancy. J Curr Ophthalmol. 2018 Jan 3;30(3):202-210. doi: 10.1016/j.joco.2017.11.012</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">· Naderan M. Ocular changes during pregnancy. J Curr Ophthalmol. 2018 Jan 3;30(3):202-210. doi: 10.1016/j.joco.2017.11.012</mixed-citation><mixed-citation xml:lang="en">·	Schlote T. Mode of action, clinical profile and significance of beta-blockers in antiglaucoma therapy. Klin Monbl Augenheilkd 2013; 230: 120–126. DOI: 10.1055/s-0032-1327784</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">· Schlote T. Mode of action, clinical profile and significance of beta-blockers in antiglaucoma therapy. Klin Monbl Augenheilkd 2013; 230: 120–126. DOI: 10.1055/s-0032-1327784</mixed-citation><mixed-citation xml:lang="en">·	Özcan KS, Güng B, Osmonov D, et al. Management and outcome of topical betablocker-induced atrioventricular block. Cardiovasc J Afr 2015; 26: 210–213. DOI: 10.5830/CVJA-2015-030</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">· Özcan KS, Güng B, Osmonov D, et al. Management and outcome of topical betablocker-induced atrioventricular block. Cardiovasc J Afr 2015; 26: 210–213. DOI: 10.5830/CVJA-2015-030</mixed-citation><mixed-citation xml:lang="en">·	Ersbøll AS, Hedegaard M, Søndergaard L, et al. Treatment with oral beta-blockers during pregnancy complicated by maternal heart disease increases the risk of fetal growth restriction. BJOG 2014; 121: 618–626.DOI: 10.1111/1471-0528.12522</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">· Ersbøll AS, Hedegaard M, Søndergaard L, et al. Treatment with oral beta-blockers during pregnancy complicated by maternal heart disease increases the risk of fetal growth restriction. BJOG 2014; 121: 618–626.DOI: 10.1111/1471-0528.12522</mixed-citation><mixed-citation xml:lang="en">·	Xie RH, Guo Y, Krewski D, et al. Beta-blockers increase the risk of being born small for gestational age or of being institutionalised during infancy. BJOG 2014; 121: 1090–1096. DOI: 10.1111/1471-0528.12678</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">· Xie RH, Guo Y, Krewski D, et al. Beta-blockers increase the risk of being born small for gestational age or of being institutionalised during infancy. BJOG 2014; 121: 1090–1096. DOI: 10.1111/1471-0528.12678</mixed-citation><mixed-citation xml:lang="en">·	Rayburn W.F., Zuspan F.P. Drug therapy in obstetrics and gynecology. 3rd Ed. St. Louis: Mosby Year Book, 1992. P. 194–197.PMID: 7821867</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">· Rayburn W.F., Zuspan F.P. Drug therapy in obstetrics and gynecology. 3rd Ed. St. Louis: Mosby Year Book,1992. P. 194–197.PMID: 7821867</mixed-citation><mixed-citation xml:lang="en">·	Brauner SC, Chen TC, Hutchinson BT, et al. The course of glaucoma during pregnancy: a retrospective case series. Arch Ophthalmol 2006; 124: 1089–1094.DOI: 10.1001/archopht.124.8.1089</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">· Brauner SC, Chen TC, Hutchinson BT, et al. The course of glaucoma during pregnancy: a retrospective case series. Arch Ophthalmol 2006; 124: 1089–1094. DOI: 10.1001/archopht.124.8.1089</mixed-citation><mixed-citation xml:lang="en">·	Ho JD, Hu CC, Lin HC. Antiglaucoma medications during pregnancy and the risk of low birth weight: a population-based study. Br J Ophthalmol 2009; 93: 1283–1286.DOI: 10.1136/bjo.2008.157123</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">· Ho JD, Hu CC, Lin HC. Antiglaucoma medications during pregnancy and the risk of low birth weight: a population-based study. Br J Ophthalmol 2009; 93: 1283–1286.DOI: 10.1136/bjo.2008.157123</mixed-citation><mixed-citation xml:lang="en">Kiseleva O.A., Yakubova L.V., Bessmertny A.M. Beta-blockers in modern glaucoma therapy. Review // Ophthalmology. 2013. No. 10 (2). pp. 20-23.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Киселева О.А., Якубова Л.В., Бессмертный А.М. Бета-блокаторы в современной терапии глаукомы. Обзор // Офтальмология. 2013. № 10 (2). С. 20–23.</mixed-citation><mixed-citation xml:lang="en">·	 Razeghinejad MR, Nowroozzadeh MH. Anti-glaucoma medication exposure in pregnancy: an observational study and literature review. Clin Exp Optom 2010; 93: 458–465. DOI: 10.1111/j.1444-0938.2010.00526.x</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">· Razeghinejad MR, Nowroozzadeh MH. Anti-glaucoma medication exposure in pregnancy: an observational study and literature review. Clin Exp Optom 2010; 93: 458–465. DOI: 10.1111/j.1444-0938.2010.00526.x</mixed-citation><mixed-citation xml:lang="en">·	 Madadi P, Koren G, Freeman DJ, et al. Timolol concentrations in breast milk of a woman treated with glaucoma: calculation of neonatal exposure. J Glaucoma 2008; 17: 329331. DOI: 10.1097/IJG.0b013e31815c3a5b</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">· Madadi P, Koren G, Freeman DJ, et al. Timolol concentrations in breast milk of a woman treated with glaucoma: calculation of neonatal exposure. J Glaucoma 2008; 17: 329331. DOI: 10.1097/IJG.0b013e31815c3a5b</mixed-citation><mixed-citation xml:lang="en">Wagenvoort AM, van Vugt JM, Sobotka M, et al. Topical timolol therapy in pregnancy: is it safe for the fetus. Teratology 1998; 58: 258–262.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Wagenvoort AM, van Vugt JM, Sobotka M, et al. Topical timolol therapy in pregnancy: is it safe for the fetus. Teratology 1998; 58: 258–262.</mixed-citation><mixed-citation xml:lang="en">DOI: 10.1002/(SICI)1096-9926(199812</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">DOI: 10.1002/(SICI)1096-9926(199812</mixed-citation><mixed-citation xml:lang="en">)58:6&lt;258::AID-TERA7&gt;3.0.CO;2-B</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">)58:6&lt;258::AID-TERA7&gt;3.0.CO;2-B</mixed-citation><mixed-citation xml:lang="en">·	Brauner SC, Chen TC, Hutchinson BT, et al. The course of glaucoma during pregnancy: a retrospective case series. Arch Ophthalmol 2006; 124: 1089–1094.DOI: 10.1001/archopht.124.8.1089</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">· Brauner SC, Chen TC, Hutchinson BT, et al. The course of glaucoma during pregnancy: a retrospective case series. Arch Ophthalmol 2006; 124: 1089–1094. DOI: 10.1001/archopht.124.8.1089</mixed-citation><mixed-citation xml:lang="en">·	Morselli PL, Boutroy MJ, Bianchetti G, et al. Placental transfer and perinatal pharmacokinetics of betaxolol. Eur J Clin Pharmacol 1990; 38: 477–483.DOI: 10.1007/BF02336687</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">·	Chung C.Y., Kwok A.K., Chung K.L. Use of ophthalmic medications during pregnancy. Hong Kong Med. J. 2004;10:191–195.PMID: 15181224</mixed-citation><mixed-citation xml:lang="en">·	Chung C.Y., Kwok A.K., Chung K.L. Use of ophthalmic medications during pregnancy. Hong Kong Med. J. 2004;10:191–195.PMID: 15181224</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">· Morselli PL, Boutroy MJ, Bianchetti G, et al. Placental transfer and perinatal pharmacokinetics of betaxolol. Eur J Clin Pharmacol 1990; 38: 477–483.DOI: 10.1007/BF02336687</mixed-citation><mixed-citation xml:lang="en">Kuzelová M., Jurinová J., Jencová D. et al. Development of a withdrawal syndrome in a neonate after long-term therapy of the mother with metipranolol during pregnancy // Cesk. Pediatr. 1993. Vol. 48. № 10. P. 608–610.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">· Chung C.Y., Kwok A.K., Chung K.L. Use of ophthalmic medications during pregnancy. Hong Kong Med. J. 2004;10:191–195. PMID: 15181224</mixed-citation><mixed-citation xml:lang="en">Kiseleva O.A., Yakubova L.V., Kosakian S.M. Vasilenkova L.V. The effect of antihypertensive drugs on the course of pregnancy in patients with glaucoma: data from experimental and clinical observations 2018. No. 3 (28). pp. 20-26.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Kuzelová M., Jurinová J., Jencová D. et al. Development of a withdrawal syndrome in a neonate after long-term therapy of the mother with metipranolol during pregnancy // Cesk. Pediatr. 1993. Vol. 48. № 10. P. 608–610.</mixed-citation><mixed-citation xml:lang="en">·	American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. doi: 10.1542/peds.108.3.776. PMID: 11533352. DOI: 10.1542/peds.108.3.776</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Киселева О.А., Якубова Л.В., Косакаян С.М. Василенкова Л.В. Влияние гипотензивных препаратов на течение беременности у пациенток с глаукомой: данные экспериментальных и клинических наблюдений 2018. № 3 (28). С. 20–26.</mixed-citation><mixed-citation xml:lang="en">·	Rama Sastry BV, Olubadewo J, Harbison RD, et al. Human placental cholinergic system. Occurrence, distribution and variation with gestational age of acetylcholine in human placenta. Biochem Pharmacol 1976; 25: 425–431.DOI: 10.1016/0006-2952(76)90345-2</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">· American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. doi: 10.1542/peds.108.3.776. PMID: 11533352. DOI: 10.1542/peds.108.3.776</mixed-citation><mixed-citation xml:lang="en">Walter L. The teratogenic activity of pilocarpine, pilocarpidine and their isomers, with special reference to the importance of steric configuration. J Exper 1956; 132: 39–50.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">· Rama Sastry BV, Olubadewo J, Harbison RD, et al. Human placental cholinergic system. Occurrence, distribution and variation with gestational age of acetylcholine in human placenta. Biochem Pharmacol 1976; 25: 425–431. DOI: 10.1016/0006-2952(76)90345-2</mixed-citation><mixed-citation xml:lang="en">·	King R.G., Gude N.M., Krishna B.R. et al. Human placental acetylcholine // Reprod. Fertil. Dev. 1991. Vol. 3. № 4. P. 405–411.DOI: 10.1071/rd9910405</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Walter L. The teratogenic activity of pilocarpine, pilocarpidine and their isomers, with special reference to the importance of steric configuration. J Exper 1956; 132: 39–50.</mixed-citation><mixed-citation xml:lang="en">·	Keränen A, Nykänen S, Taskinen J. Pharmacokinetics and side-effects of Clonidine . Eur J Clin Pharmacol 1978; 13 : 97–101.  DOI: 10.1007/BF00609752</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">· King R.G., Gude N.M., Krishna B.R. et al. Human placental acetylcholine // Reprod. Fertil. Dev. 1991. Vol. 3. № 4. P. 405–411.DOI: 10.1071/rd9910405</mixed-citation><mixed-citation xml:lang="en">·	Holmes L.B., Kawanishi H., Munoz A. Acetazolamide: maternal toxicity, pattern of malformations, and litter effect // Teratology. 1988. Vol. 37. № 4. P. 335–342.DOI: 10.1002/tera.1420370407</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">· Keränen A, Nykänen S, Taskinen J. Pharmacokinetics and side-effects of Clonidine . Eur J Clin Pharmacol 1978; 13 : 97–101. DOI: 10.1007/BF00609752</mixed-citation><mixed-citation xml:lang="en">·	 Lee AG, Pless M, Falardeau J, et al. The use of acetazolamide in idiopathic intracranial hypertension during pregnancy // Am. J. Ophthalmol. 2005. Vol. 139. No 5. P. 855–859.DOI: 10.1016/j.ajo.2004.12.091</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">· Holmes L.B., Kawanishi H., Munoz A. Acetazolamide: maternal toxicity, pattern of malformations, and litter effect // Teratology. 1988. Vol. 37. № 4. P. 335–342.DOI: 10.1002/tera.1420370407</mixed-citation><mixed-citation xml:lang="en">·	Rosenfeld C.R., Barton M.D., Meschia G. Effects of epinephrine on distribution of blood flow in the pregnant ewe // Am. J. Obstet. Gynecol. 1976. Vol. 124. № 2. P. 156–163.DOI: 10.1016/s0002-9378(16)33292-6</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">· Lee AG, Pless M, Falardeau J, et al. The use of acetazolamide in idiopathic intracranial hypertension during pregnancy // Am. J. Ophthalmol. 2005. Vol. 139. No 5. P. 855–859.DOI: 10.1016/j.ajo.2004.12.091</mixed-citation><mixed-citation xml:lang="en">·	Netland P. Glaucoma medical therapy: principles and management. 2nd ed. New York: Oxford University Press, 2008.DOI: 10.1016/S0079-6123(08)01113-8</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">· Rosenfeld C.R., Barton M.D., Meschia G. Effects of epinephrine on distribution of blood flow in the pregnant ewe // Am. J. Obstet. Gynecol. 1976. Vol. 124. № 2. P. 156–163.DOI: 10.1016/s0002-9378(16)33292-6</mixed-citation><mixed-citation xml:lang="en">Wang SK, Chang RT. An emerging treatment option for glaucoma: Rho kinase inhibitors. Clin Ophthalmol 2014; 8: 883–890. DOI: 10.2147/OPTH.S41000</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">· Netland P. Glaucoma medical therapy: principles and management. 2nd ed. New York: Oxford University Press, 2008. DOI: 10.1016/S0079-6123(08)01113-8</mixed-citation><mixed-citation xml:lang="en">·	Sethi HS, Naik M, Gupta VS. Management of glaucoma in pregnancy: risks or choices, a dilemma? Int J Ophthalmol 2016; 9: 1684–1690.DOI: 10.18240/ijo.2016.11.24</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">· Wang SK, Chang RT. An emerging treatment option for glaucoma: Rho kinase inhibitors. Clin Ophthalmol 2014; 8: 883–890.</mixed-citation><mixed-citation xml:lang="en">·	 Gardey-Levassort C., Ventura M.A., Thiroux G. et al. An attempt to identify – adrenoceptors in the human placenta // Dev. Pharmacol. Ther. 1984. Vol. 7. № 1. P. 85–88.DOI: 10.1159/000457233</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">· . DOI: 10.2147/OPTH.S41000</mixed-citation><mixed-citation xml:lang="en">·	Ozawa H, Azuma E, Shindo K, et al. Transient renal tubular acidosis in a neonate following transplacental acetazolamide. Eur J Pediatr 2001; 160: 321–322. DOI: 10.1007/pl00008441</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">· Sethi HS, Naik M, Gupta VS. Management of glaucoma in pregnancy: risks or choices, a dilemma? Int J Ophthalmol 2016; 9: 1684–1690. DOI: 10.18240/ijo.2016.11.24</mixed-citation><mixed-citation xml:lang="en">Product information. Trusopt. Merck, 1999. West Point, PA. (Manufacturer’s information: trusopt product monograph. Pennsylvania: Merck &amp; Co Inc, West Point, 1999).</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">· Gardey-Levassort C., Ventura M.A., Thiroux G. et al. An attempt to identify – adrenoceptors in the human placenta // Dev. Pharmacol. Ther. 1984. Vol. 7. № 1. P. 85–88.DOI: 10.1159/000457233</mixed-citation><mixed-citation xml:lang="en">·	 Hoffmanovã I, Sãnchez D. Metabolic acidosis and anaemia associated with dorzolamide in a patient with impaired renal function. Br J Clin Pharmacol 2018; 84: 796–799.DOI: 10.1111/bcp.13499</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">· Ozawa H, Azuma E, Shindo K, et al. Transient renal tubular acidosis in a neonate following transplacental acetazolamide. Eur J Pediatr 2001; 160: 321–322. DOI: 10.1007/pl00008441</mixed-citation><mixed-citation xml:lang="en">·	Capino AC, Dannaway DC, Miller JL. Metabolic acidosis with ophthalmic dorzolamide in a neonate. J Pediatr Pharmacol Ther 2016; 21: 256–259.DOI: 10.5863/1551-6776-21.3.256</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Product information. Trusopt. Merck, 1999. West Point, PA. (Manufacturer’s information: trusopt product monograph. Pennsylvania: Merck &amp; Co Inc, West Point, 1999).</mixed-citation><mixed-citation xml:lang="en">·	Al-Saleem AI, Al-Jobair AM. Possible association between acetazolamide administration during pregnancy and multiple congenital malformations. Drug Des Devel Ther 2016; 10: 1471–1476.DOI: 10.2147/DDDT.S99561</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">· Hoffmanovã I, Sãnchez D. Metabolic acidosis and anaemia associated with dorzolamide in a patient with impaired renal function. Br J Clin Pharmacol 2018; 84: 796–799. DOI: 10.1111/bcp.13499</mixed-citation><mixed-citation xml:lang="en">·	. Falardeau J, Lobb BM, Golden S, et al. The use of acetazolamide during pregnancy in intracranial hypertension patients. J Neuroophthalmol 2013; 33: 9–12.DOI: 10.1097/WNO.0b013e3182594001</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">· Capino AC, Dannaway DC, Miller JL. Metabolic acidosis with ophthalmic dorzolamide in a neonate. J Pediatr Pharmacol Ther 2016; 21: 256–259. DOI: 10.5863/1551-6776-21.3.256</mixed-citation><mixed-citation xml:lang="en">Worsham G.F., Beckman E.N., Mitchell E.H. Sacrococcygeal teratoma in a neonate. Association with maternal use of acetazolamide // JAMA. 1978. Vol. 240. № 3. P. 251–252.</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">· Al-Saleem AI, Al-Jobair AM. Possible association between acetazolamide administration during pregnancy and multiple congenital malformations. Drug Des Devel Ther 2016; 10: 1471–1476. DOI: 10.2147/DDDT.S99561</mixed-citation><mixed-citation xml:lang="en">Mcbride W.G. The teratogenic action of drugs // Med. J. Aust. 1963. Vol. 2. P. 689–692.</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">· Falardeau J, Lobb BM, Golden S, et al. The use of acetazolamide during pregnancy in intracranial hypertension patients. J Neuroophthalmol 2013; 33: 9–12.DOI: 10.1097/WNO.0b013e3182594001</mixed-citation><mixed-citation xml:lang="en">·	Dieckmann W.J., Harrod J., Monardo A. The treatment of pre-eclamptic edema with acetazoleamide (diamox) // Am. J. Obstet. Gynecol. 1957. Vol. 73. № 4. P. 789–800.DOI: 10.1016/0002-9378(57)90388-5</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">Worsham G.F., Beckman E.N., Mitchell E.H. Sacrococcygeal teratoma in a neonate. Association with maternal use of acetazolamide // JAMA. 1978. Vol. 240. № 3. P. 251–252.</mixed-citation><mixed-citation xml:lang="en">·	Merlob P., Litwin A., Mor N. Possible association between acetazolamide administration during pregnancy and metabolic disorders in the newborn // Eur. J. Obstet. Gynecol. Reprod. Biol. 1990. Vol. 35. № 1. P. 85–88.DOI: 10.1016/0028-2243(90)90146-r</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">Mcbride W.G. The teratogenic action of drugs // Med. J. Aust. 1963. Vol. 2. P. 689–692.</mixed-citation><mixed-citation xml:lang="en">·	Crane C.H. Effect on fetus of mother taking a diuretic // JAMA. 1957. Vol. 165.DOI: 10.1097/MD.0000000000013185</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">· Dieckmann W.J., Harrod J., Monardo A. The treatment of pre-eclamptic edema with acetazoleamide (diamox) // Am. J. Obstet. Gynecol. 1957. Vol. 73. № 4. P. 789–800.DOI: 10.1016/0002-9378(57)90388-5</mixed-citation><mixed-citation xml:lang="en">Aerie Pharmaceuticals. Rhopressa (netarsudil ophthalmic solution) 0.02% [package insert]. Silver Spring, MD: US Food and Drug Administration, 2017.</mixed-citation></citation-alternatives></ref><ref id="cit86"><label>86</label><citation-alternatives><mixed-citation xml:lang="ru">· Merlob P., Litwin A., Mor N. Possible association between acetazolamide administration during pregnancy and metabolic disorders in the newborn // Eur. J. Obstet. Gynecol. Reprod. Biol. 1990. Vol. 35. № 1. P. 85–88.DOI: 10.1016/0028-2243(90)90146-r</mixed-citation><mixed-citation xml:lang="en">·	Ergul M, Turgut NH, Sarac B, et al. Investigating the effects of the Rho-kinase enzyme inhibitors AS1892802 and fasudil hydrochloride on the contractions of isolated pregnant rat myometrium. Eur J Obstet Gynecol Reprod Biol 2016; 202: 45–50.DOI: 10.1016/j.ejogrb.2016.04.031</mixed-citation></citation-alternatives></ref><ref id="cit87"><label>87</label><citation-alternatives><mixed-citation xml:lang="ru">· Crane C.H. Effect on fetus of mother taking a diuretic // JAMA. 1957. Vol. 165.DOI: 10.1097/MD.0000000000013185</mixed-citation><mixed-citation xml:lang="en">·	Tahara M, Kawagishi R, Sawada K, et al. Tocolytic effect of a Rho-kinase inhibitor in a mouse model of lipopolysaccharide-induced preterm delivery. Am J Obstet Gynecol 2005; 192: 903–908. DOI: 10.1016/j.ajog.2004.09.016</mixed-citation></citation-alternatives></ref><ref id="cit88"><label>88</label><citation-alternatives><mixed-citation xml:lang="ru">Aerie Pharmaceuticals. Rhopressa (netarsudil ophthalmic solution) 0.02% [package insert]. Silver Spring, MD: US Food and Drug Administration, 2017.</mixed-citation><mixed-citation xml:lang="en">Sherwood M.B., Migdal C.S., Hitchings R.A. et al. Initial treatment of glaucoma: surgery or medications // Surv. Ophthalmol. 1993. Vol. 37. № 4. P. 293–305</mixed-citation></citation-alternatives></ref><ref id="cit89"><label>89</label><citation-alternatives><mixed-citation xml:lang="ru">· Ergul M, Turgut NH, Sarac B, et al. Investigating the effects of the Rho-kinase enzyme inhibitors AS1892802 and fasudil hydrochloride on the contractions of isolated pregnant rat myometrium. Eur J Obstet Gynecol Reprod Biol 2016; 202: 45–50. DOI: 10.1016/j.ejogrb.2016.04.031</mixed-citation><mixed-citation xml:lang="en">Výborný P, Sičáková S, Flórová Z, et al. [Selective laser trabeculoplasty—Implication for medicament glaucoma treatment interruption in pregnant and breastfeeding women]. Cesk Slov Oftalmol. 2017; 73 : 61–63</mixed-citation></citation-alternatives></ref><ref id="cit90"><label>90</label><citation-alternatives><mixed-citation xml:lang="ru">· Tahara M, Kawagishi R, Sawada K, et al. Tocolytic effect of a Rho-kinase inhibitor in a mouse model of lipopolysaccharide-induced preterm delivery. Am J Obstet Gynecol 2005; 192: 903–908. DOI: 10.1016/j.ajog.2004.09.016</mixed-citation><mixed-citation xml:lang="en">·	Migdal C.S., Gregory W., Hitchings R. Long-term functional outcome after early surgery compared with laser and medicine in open-angle glaucoma // Ophthalmology. 1994. Vol. 101. № 10. P. 1651–1656.DOI: 10.1016/s0161-6420(94)31120-1</mixed-citation></citation-alternatives></ref><ref id="cit91"><label>91</label><citation-alternatives><mixed-citation xml:lang="ru">Sherwood M.B., Migdal C.S., Hitchings R.A. et al. Initial treatment of glaucoma: surgery or medications // Surv. Ophthalmol. 1993. Vol. 37. № 4. P. 293–305</mixed-citation><mixed-citation xml:lang="en">·	McIlraith I, Strasfeld M, Colev G, et al. Selective laser trabeculoplasty as initial and adjunctive treatment for open angle glaucoma. J Glaucoma 2006; 15: 124–130. DOI: 10.1097/00061198-200604000-00009</mixed-citation></citation-alternatives></ref><ref id="cit92"><label>92</label><citation-alternatives><mixed-citation xml:lang="ru">Výborný P, Sičáková S, Flórová Z, et al. [Selective laser trabeculoplasty—Implication for medicament glaucoma treatment interruption in pregnant and breastfeeding women]. Cesk Slov Oftalmol. 2017; 73 : 61–63</mixed-citation><mixed-citation xml:lang="en">·	Wertheim M, Broadway DC. Cyclodiode laser therapy to control intraocular pressure during pregnancy. Br J Ophthalmol 2002; 86: 1318–1319.DOI: 10.1136/bjo.86.11.1318</mixed-citation></citation-alternatives></ref><ref id="cit93"><label>93</label><citation-alternatives><mixed-citation xml:lang="ru">· Migdal C.S., Gregory W., Hitchings R. Long-term functional outcome after early surgery compared with laser and medicine in open-angle glaucoma // Ophthalmology. 1994. Vol. 101. № 10. P. 1651–1656.DOI: 10.1016/s0161-6420(94)31120-1</mixed-citation><mixed-citation xml:lang="en">Fudemberg SJ, Myers JS, Katz LJ. Trabecular meshwork tissue examination with scanning electron microscopy: a comparison of micropulse diode laser (MLT), selective laser (SLT), and argon laser (ALT) trabeculoplasty in human cadaver tissue. Investig Ophthalmol Vis Sci 2008; 49: 1236</mixed-citation></citation-alternatives></ref><ref id="cit94"><label>94</label><citation-alternatives><mixed-citation xml:lang="ru">· McIlraith I, Strasfeld M, Colev G, et al. Selective laser trabeculoplasty as initial and adjunctive treatment for open angle glaucoma. J Glaucoma 2006; 15: 124–130.DOI: 10.1097/00061198-200604000-00009</mixed-citation><mixed-citation xml:lang="en">·	Johnson SM, Martinez M. Management of glaucoma in pregnancy and lactation. Surv Ophthalmol 2001; 45: 449–454.DOI: 10.1016/s0039-6257(00)00209-5</mixed-citation></citation-alternatives></ref><ref id="cit95"><label>95</label><citation-alternatives><mixed-citation xml:lang="ru">· Wertheim M, Broadway DC. Cyclodiode laser therapy to control intraocular pressure during pregnancy. Br J Ophthalmol 2002; 86: 1318–1319.DOI: 10.1136/bjo.86.11.1318</mixed-citation><mixed-citation xml:lang="en">·	Zehavi-Dorin T, Heinecke E, Nadkarni S, et al. Bilateral consecutive Xen gel stent surgery during pregnancy for uncontrolled early-onset primary open angle glaucoma. Am J Ophthalmol Case Rep 2019; 15: 100510. DOI: 10.1016/j.ajoc.2019.100510</mixed-citation></citation-alternatives></ref><ref id="cit96"><label>96</label><citation-alternatives><mixed-citation xml:lang="ru">Fudemberg SJ, Myers JS, Katz LJ. Trabecular meshwork tissue examination with scanning electron microscopy: a comparison of micropulse diode laser (MLT), selective laser (SLT), and argon laser (ALT) trabeculoplasty in human cadaver tissue. Investig Ophthalmol Vis Sci 2008; 49: 1236</mixed-citation><mixed-citation xml:lang="en">·	Ayyala RS, Zurakowski D, Smith JA, et al. A clinical study of the Ahmed glaucoma valve implant in advanced glaucoma. Ophthalmology 1998; 105: 1968–1976 .DOI: 10.1016/S0161-6420(98)91049-1</mixed-citation></citation-alternatives></ref><ref id="cit97"><label>97</label><citation-alternatives><mixed-citation xml:lang="ru">· Johnson SM, Martinez M. Management of glaucoma in pregnancy and lactation. Surv Ophthalmol 2001; 45: 449–454.DOI: 10.1016/s0039-6257(00)00209-5</mixed-citation><mixed-citation xml:lang="en">Flach A.J. The importance of eyelid closure and nasolacrimal occlusion following the ocular instillation of topical glaucoma medications, and the need for the universal inclusion of one of these techniques in all patient treatments and clinical studies // Trans. Am. Ophthalmol. Soc. 2008. Vol. 106. P. 138–145.</mixed-citation></citation-alternatives></ref><ref id="cit98"><label>98</label><citation-alternatives><mixed-citation xml:lang="ru">· Zehavi-Dorin T, Heinecke E, Nadkarni S, et al. Bilateral consecutive Xen gel stent surgery during pregnancy for uncontrolled early-onset primary open angle glaucoma. Am J Ophthalmol Case Rep 2019; 15: 100510. DOI: 10.1016/j.ajoc.2019.100510</mixed-citation><mixed-citation xml:lang="en">·	Emanuel ME, Gedde SJ. Indications for a systemic work-up in glaucoma. Can J Ophthalmol 2014; 49: 506–511.DOI: 10.1016/j.jcjo.2014.10.00</mixed-citation></citation-alternatives></ref><ref id="cit99"><label>99</label><citation-alternatives><mixed-citation xml:lang="ru">· Ayyala RS, Zurakowski D, Smith JA, et al. A clinical study of the Ahmed glaucoma valve implant in advanced glaucoma. Ophthalmology 1998; 105: 1968–1976.DOI: 10.1016/S0161-6420(98)91049-1</mixed-citation><mixed-citation xml:lang="en">·	Nouri-Mahdavi K, Caprioli J. Evaluation of the hypertensive phase after insertion of the Ahmed Glaucoma Valve. Am J Ophthalmol 2003; 136: 1001–1008.DOI: 10.1016/s0002-9394(03)00630-5</mixed-citation></citation-alternatives></ref><ref id="cit100"><label>100</label><citation-alternatives><mixed-citation xml:lang="ru">Flach A.J. The importance of eyelid closure and nasolacrimal occlusion following the ocular instillation of topical glaucoma medications, and the need for the universal inclusion of one of these techniques in all patient treatments and clinical studies // Trans. Am. Ophthalmol. Soc. 2008. Vol. 106. P. 138–145.</mixed-citation><mixed-citation xml:lang="en">·	 Pitukcheewanont O, Tantisevi V, Chansangpetch S, et al. Factors related to hypertensive phase after glaucoma drainage device implantation. Clin Ophthalmol 2018; 12: 1479–1486. DOI: 10.2147/OPTH.S166244</mixed-citation></citation-alternatives></ref><ref id="cit101"><label>101</label><citation-alternatives><mixed-citation xml:lang="ru">· Emanuel ME, Gedde SJ. Indications for a systemic work-up in glaucoma. Can J Ophthalmol 2014; 49: 506–511.DOI: 10.1016/j.jcjo.2014.10.001</mixed-citation><mixed-citation xml:lang="en">·	Lu LJ, Hall L, Liu J. Improving glaucoma surgical outcomes with adjunct tools. J Curr Glaucoma Pract 2018; 12: 19–28. DOI: 10.5005/jp-journals-10028-1239</mixed-citation></citation-alternatives></ref><ref id="cit102"><label>102</label><citation-alternatives><mixed-citation xml:lang="ru">· Nouri-Mahdavi K, Caprioli J. Evaluation of the hypertensive phase after insertion of the Ahmed Glaucoma Valve. Am J Ophthalmol 2003; 136: 1001–1008. DOI: 10.1016/s0002-9394(03)00630-5</mixed-citation><mixed-citation xml:lang="en">Heinonen OP, Sloane D, Shapiro S. Birth defects and drugs in pregnancy. Littleton, MA: Publishing Science Group, 1977, pp. 357–365</mixed-citation></citation-alternatives></ref><ref id="cit103"><label>103</label><citation-alternatives><mixed-citation xml:lang="ru">· Pitukcheewanont O, Tantisevi V, Chansangpetch S, et al. Factors related to hypertensive phase after glaucoma drainage device implantation. Clin Ophthalmol 2018; 12: 1479–1486. DOI: 10.2147/OPTH.S166244</mixed-citation><mixed-citation xml:lang="en">·	Moore PA. Selecting drugs for the pregnant dental patient. J Am Dent Assoc 1998; 129: 1281–1286.DOI: 10.14219/jada.archive.1998.0425</mixed-citation></citation-alternatives></ref><ref id="cit104"><label>104</label><citation-alternatives><mixed-citation xml:lang="ru">· Lu LJ, Hall L, Liu J. Improving glaucoma surgical outcomes with adjunct tools. J Curr Glaucoma Pract 2018; 12: 19–28. DOI: 10.5005/jp-journals-10028-1239</mixed-citation><mixed-citation xml:lang="en">Zeyen T, Coppens G. Medical treatment: the pregnant and nursing woman. In: Giaconi JA, Law SK, Coleman AL, et al. (eds) Pearls of glaucoma management. Berlin: Springer, 2010, pp. 203–205</mixed-citation></citation-alternatives></ref><ref id="cit105"><label>105</label><citation-alternatives><mixed-citation xml:lang="ru">Heinonen OP, Sloane D, Shapiro S. Birth defects and drugs in pregnancy. Littleton, MA: Publishing Science Group, 1977, pp. 357–365</mixed-citation><mixed-citation xml:lang="en">·	Morris S, Geh V, Nischal KK, et al. Topical dorzolamide and metabolic acidosis in a neonate . Br J Ophthalmol 2003; 87 : 1052–1053. DOI: 10.1136/bjo.87.8.1052</mixed-citation></citation-alternatives></ref><ref id="cit106"><label>106</label><citation-alternatives><mixed-citation xml:lang="ru">· Moore PA. Selecting drugs for the pregnant dental patient. J Am Dent Assoc 1998; 129: 1281–1286.DOI: 10.14219/jada.archive.1998.0425</mixed-citation><mixed-citation xml:lang="en">· Moore PA. Selecting drugs for the pregnant dental patient. J Am Dent Assoc 1998; 129: 1281–1286.DOI: 10.14219/jada.archive.1998.0425</mixed-citation></citation-alternatives></ref><ref id="cit107"><label>107</label><citation-alternatives><mixed-citation xml:lang="ru">Zeyen T, Coppens G. Medical treatment: the pregnant and nursing woman. In: Giaconi JA, Law SK, Coleman AL, et al. (eds) Pearls of glaucoma management. Berlin: Springer, 2010, pp. 203–205</mixed-citation><mixed-citation xml:lang="en">Zeyen T, Coppens G. Medical treatment: the pregnant and nursing woman. In: Giaconi JA, Law SK, Coleman AL, et al. (eds) Pearls of glaucoma management. Berlin: Springer, 2010, pp. 203–205</mixed-citation></citation-alternatives></ref><ref id="cit108"><label>108</label><citation-alternatives><mixed-citation xml:lang="ru">· Morris S, Geh V, Nischal KK, et al. Topical dorzolamide and metabolic acidosis in a neonate . Br J Ophthalmol 2003; 87 : 1052–1053. DOI: 10.1136/bjo.87.8.1052</mixed-citation><mixed-citation xml:lang="en">· Morris S, Geh V, Nischal KK, et al. Topical dorzolamide and metabolic acidosis in a neonate . Br J Ophthalmol 2003; 87 : 1052–1053. DOI: 10.1136/bjo.87.8.1052</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
