glaucomaНациональный журнал ГлаукомаNational Journal glaucoma2078-41042311-6862Federal State Budgetary Institution of Science “Krasnov Research Institute of Eye Diseases”10.53432/2078-4104-2024-23-2-107-116glaucoma-529Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSГлаукома и метаболический синдромGlaucoma and metabolic syndromehttps://orcid.org/0000-0002-4900-6193ГетмановаА. М.GetmanovaA. M.

Гетманова Анастасия Михайловна, врач-офтальмолог; заочный аспирант кафедры офтальмологии

241028, Брянск, просп. Станке Димитрова, 86, корп. 1

305041, Курск, ул. К. Маркса, 3

ophthalmologist; postgraduate student at the Academic Department of Ophthalmology

86/1 Stanke Dimitrova Ave., Bryansk, 241028

3 Karla Marksa St., Kursk, 305041

anastasiagetmanova@gmail.comhttps://orcid.org/0000-0002-5597-983XБрежневА. М.BrezhnevA. Yu.

к.м.н., доцент кафедры офтальмологии

305041, Курск, ул. К. Маркса, 3

Cand. Sci. (Med.), Associate Professor at the Academic Department of Ophthalmology

3 Karla Marksa St., Kursk, 305041

https://orcid.org/0000-0001-9606-0566КуроедовА. В.KuroyedovA. V.

д.м.н., профессор кафедры офтальмологии; начальник офтальмологического центра

107014, Москва, ул. Большая Оленья, владение 8а

117997, Москва, ул. Островитянова, 1

Dr. Sci. (Med.), Head of the Ophthalmology Сenter; Professor at the Academic Department of Ophthalmology

8A Bolshaya Olenya St., 117997

1 Ostrovityanova St., Moscow, 117997

https://orcid.org/0000-0002-6859-8040ЗубашеваС. А.ZubashevaS. A.

врач-офтальмолог

119021, Москва, ул. Б. Пироговская, 15/18, стр. 1.

ophthalmologist

15/18 Bolshaya Pirogovskaya St., Moscow, 119021

ГАУЗ «Брянская областная больница №1»; ФГБОУ ВО КГМУ Минздрава РФРоссияBryansk Regional Hospital No. 1; Kursk State Medical UniversityRussian FederationФГБОУ ВО КГМУ Минздрава РФРоссияKursk State Medical UniversityRussian FederationФКУ «ЦВКГ им. П.В. Мандрыка» Минобороны РФ; ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава РФРоссияMandryka Central Clinical Hospital; Pirogov Russian National Research Medical UniversityRussian FederationФГБУ «9 Лечебно-диагностический центр» Минобороны РФРоссияTreatment and Diagnostic Center No. 9Russian Federation202427062024232107116Copyright © Гетманова А.М., Брежнев А.М., Куроедов А.В., Зубашева С.А., 20242024Гетманова А.М., Брежнев А.М., Куроедов А.В., Зубашева С.А.Getmanova A.M., Brezhnev A.Y., Kuroyedov A.V., Zubasheva S.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.glaucomajournal.ru/jour/article/view/529

Исследования последних лет показывают рост распространенности системных заболеваний, ряд из которых, возможно, являются независимыми факторами риска и прогрессирования глаукомы. Метаболический синдром (МС) в настоящее время является одной из ведущих проблем здоровья населения в мире. Ряд наблюдений указывает на взаимосвязь МС и отдельных компонентов этого процесса (в частности, инсулинорезистентности, гипергликемии, нарушения системы гомеостаза и системной артериальной гипертензии) с повышением уровня внутриглазного давления (ВГД), развитием офтальмогипертензии и возникновением первичной открытоугольной глаукомы (ПОУГ). Однако, недостаточное количество научных работ по этой тематике, различия в их методологии и противоречивые результаты не позволяют сделать однозначных выводов о роли МС в этиопатогенезе глаукомного процесса. Необходимы дальнейшие исследования, которые позволят определить роль и место МС в возникновении и развитии ПОУГ и перспективы прикладного применения этих знаний. В настоящем обзоре представлены литературные данные, касающиеся влияния МС и отдельных его компонентов на показатели ВГД, возникновение и развитие глаукомы, а также на некоторые другие офтальмологические заболевания.

Studies in recent years have shown an increase in the prevalence of systemic diseases, some of which may be independent risk factors for the development and progression of glaucoma. Metabolic syndrome (MetS) is currently one of the leading public health problems in the world. Some studies indicate a relationship between MetS and its individual components (in particular, insulin resistance, hyperglycemia, impaired homeostasis, and systemic arterial hypertension) with an increase in intraocular pressure (IOP), ocular hypertension, and the development of primary open-angle glaucoma (POAG). However, no unambiguous conclusions about the role of MetS in the pathogenesis of glaucoma has been established due to the insufficient number of scientific studies on this topic, the differences in their methodology, and the contradictory results. Further research is needed to determine the role and place of MetS in the occurrence and development of POAG, and the prospects for the practical application of this knowledge.

This review presents literature data on the effect of MetS and its individual components on IOP, occurrence and development of glaucoma and several other ophthalmic diseases

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The authors declare that there are no conflicts of interest present.