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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">glaucoma</journal-id><journal-title-group><journal-title xml:lang="ru">Национальный журнал Глаукома</journal-title><trans-title-group xml:lang="en"><trans-title>National Journal glaucoma</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-4104</issn><issn pub-type="epub">2311-6862</issn><publisher><publisher-name>Federal State Budgetary Institution of Science “Krasnov Research Institute of Eye Diseases”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.53432/2078-4104-2025-24-1-58-64</article-id><article-id custom-type="elpub" pub-id-type="custom">glaucoma-557</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERATURE REVIEWS</subject></subj-group></article-categories><title-group><article-title>Причины прогрессирования катаракты у пациентов с глаукомой (сообщение 2)</article-title><trans-title-group xml:lang="en"><trans-title>Causes of cataract progression in glaucoma patients (report 2)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5662-4195</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ивачёв</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivachev</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ивачёв Евгений Александрович, к.м.н., доцент; заведующий офтальмологическим отделением</p><p>440026, Пенза, ул. Красная 40</p><p>440600, Пенза, ул. Урицкого 118</p></bio><bio xml:lang="en"><p>Cand. Sci. (Med), Associate Professor, Head of Ophthalmology Department</p><p>40 Krasnaya St, Penza, 440026</p><p>118 Uritskogo St., Penza, 440600</p></bio><email xlink:type="simple">eivachov1@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБОУ ВО «Пензенский государственный университет»; ЧУЗ «Клиническая больница «РЖД-Медицина»<country>Россия</country></aff><aff xml:lang="en">Penza State University; Clinical hospital "RZD-Medicine"<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>26</day><month>03</month><year>2025</year></pub-date><volume>24</volume><issue>1</issue><fpage>58</fpage><lpage>64</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ивачёв Е.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Ивачёв Е.А.</copyright-holder><copyright-holder xml:lang="en">Ivachev E.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.glaucomajournal.ru/jour/article/view/557">https://www.glaucomajournal.ru/jour/article/view/557</self-uri><abstract><p>Гипотензивные лекарственные средства, проникающие во влагу передней камеры, приводят к истончению, шероховатости, неровностям, микротрещинам передней капсулы с последующим формированием микрофибрилл и псевдомембран. При наблюдении 2532 пациентов с глаукомой в течение 5 лет прогрессирование ядерной катаракты вследствие длительного применения гипотензивных капель было выявлено в 592 (23,4%) случаях.У больных с глаукомой более низкая скорость потребления кислорода хрусталиком (2,27 фемтомоль/ мин/клетка при норме 2,83 фемтомоль/мин/клетка), уменьшено использование кислорода для производства аденозинтрифосфата (0,72 фемтомоль/мин/клетка при норме 0,932 фемтомоль/мин/клетка) и снижено максимальное дыхание клеток хрусталика (4,17 против 5,46 фемтомоль/мин/клетка). Эти изменения являются фактором риска катарактогенеза.При увеальной глаукоме происходит аккумуляция протеинов крови и воспалительных клеток во влаге передней камеры, формирование задних синехий между радужкой и передней капсулой хрусталика и образование фибринозного выпота в просвете зрачка. При увеальной глаукоме используются противовоспалительная и гипотензивная медикаментозная терапии, применяются лазерные и хирургические операции с имплантацией дренажей. Эти факторы у пациентов с увеальной глаукомой приводят к учащению случаев формирования и прогрессирования катаракты на 34%.</p></abstract><trans-abstract xml:lang="en"><p>Hypotensive drops that penetrate into the aqueous humor of the anterior chamber cause thinning, roughness, irregularities, and microcracks in the anterior lens capsule, followed by the formation of microfibrils and pseudomembranes. In a five-year follow-up of 2532 glaucoma patients, nuclear cataract progression due to prolonged use of hypotensive eye drops was identified in 592 cases (23.4%).Patients with glaucoma exhibit a lower oxygen consumption rate by the lens (2.27 femtomoles/min/cell vs. a normal value of 2.83 femtomoles/min/cell), reduced oxygen utilization for adenosine triphosphate (ATP) production (0.72 femtomoles/min/cell vs. a normal value of 0.932 femtomoles/min/cell), and decreased maximal respiratory capacity of lens cells (4.17 vs. 5.46 femtomoles/min/cell). These changes represent risk factors for cataract development.In uveal glaucoma, blood proteins and inflammatory cells accumulate in the aqueous humor, posterior synechiae form between the iris and the anterior lens capsule, and fibrinous exudate develops in the pupillary area. Patients with uveal glaucoma receive anti-inflammatory and hypotensive pharmacotherapy, as well as laser and surgical treatments, including drainage device implantation. These factors contribute to a 34% increase in the incidence and progression of cataracts in uveal glaucoma patients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>глаукома</kwd><kwd>катаракта</kwd><kwd>факоэмульсификация</kwd><kwd>синустрабекулэктомия</kwd><kwd>интраокулярная линза</kwd><kwd>внутриглазное давление</kwd></kwd-group><kwd-group xml:lang="en"><kwd>glaucoma</kwd><kwd>cataract</kwd><kwd>phacoemulsification</kwd><kwd>trabeculectomy</kwd><kwd>intraocular lens</kwd><kwd>intraocular pressure</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kubota M., Shui Y.B., Liu M., Bai F., Huang A.J., Ma N., Beebe D.C., Siegfried C.J. 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