glaucomaНациональный журнал ГлаукомаNational Journal glaucoma2078-41042311-6862Federal State Budgetary Institution of Science “Krasnov Research Institute of Eye Diseases”10.53432/2078-4104-2025-24-2-61-72glaucoma-565Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSМикрошунт PRESERFLO™ для микроинвазивной хирургии глаукомыMicroshunt PRESERFLO™ for microinvasive glaucoma surgeryhttps://orcid.org/0000-0001-6842-7164ЕричевВ. П.ErichevV. P.

Еричев Валерий Петрович, д.м.н., профессор, вице-президент

Москва

Dr. Sci. (Med.), Professor, Vice President

Moscow

 

v.erichev@yandex.ruhttps://orcid.org/0000-0003-3445-8899ПершинК. Б.PershinK. B.

д.м.н., профессор, медицинский директор сети офтальмологических клиник; профессор кафедры офтальмологии АПО

125371, Москва, Волоколамское шоссе, 91

Dr. Sci. (Med.), Professor, Medical Director; Professor at the Academic Department of Ophthalmology

3/1 Marksistskaya St., Moscow, 109147; 

91 Volokolamskoe av., Moscow, 125371

https://orcid.org/0000-0002-1421-8882ВолжанинА. В.VolzhaninA. V.

к.м.н., научный сотрудник

109147, Москва, ул. Марксистская, 3, стр. 1

Cand. Sci. (Med.), researcher

11A Rossolimo St., Moscow, 119021

https://orcid.org/0000-0003-0521-2750МакароваА. С.MakarovaA. S.

к.м.н., научный сотрудник

109147, Москва, ул. Марксистская, 3, стр. 1

Cand. Sci. (Med.), researcher

11A Rossolimo St., Moscow, 119021

Общероссийская общественная организация «Российское общество офтальмологов-глаукоматологов»РоссияAll-Russian public organization "Russian society of ophthalmologists-glaucoma specialists"Russian FederationОфтальмологический центр «Эксимер»; ФГБУ ФНКЦ ФМБА РоссииРоссияOphthalmological center "Eximer"; Academy of Postgraduate Education of the Federal Medical-Biological AgencyRussian FederationОфтальмологический центр «Эксимер»РоссияKrasnov Research Institute of Eye DiseasesRussian Federation2025270520252426172Copyright © Еричев В.П., Першин К.Б., Волжанин А.В., Макарова А.С., 20252025Еричев В.П., Першин К.Б., Волжанин А.В., Макарова А.С.Erichev V.P., Pershin K.B., Volzhanin A.V., Makarova A.S.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.glaucomajournal.ru/jour/article/view/565

На сегодняшний день «золотым стандартом» хирургии глаукомы является трабекулэктомия, позволяющая достичь стойкого снижения внутриглазного давления (ВГД). Тем не менее, трабекулэктомия сравнительно травматична и ассоциируется с риском специфических осложнений. Вследствие этого к настоящему моменту был разработан ряд устройств для микроинвазивной хирургии глаукомы, предназначенных для создания сравнимого с трабекулэктомией гипотензивного эффекта вкупе с минимальной операционной травмой.

Микрошунт PRESERFLO™ (Santen) является полимерным микрошунтом для создания оттока внутриглазной жидкости под конъюнктиву с формированием фильтрационной подушки. Он имплантируется через субконъюнктивальный доступ, характерный для трабекулэктомии, однако, за счет контролируемого оттока влаги минимизирует риск развития осложнений, характерных для традиционных антиглаукомных вмешательств.

Долгосрочная (в сроки до 5 лет) эффективность и безопасность имплантации микрошунт PRESERFLO™ показаны в ряде исследований, в том числе сравнивающих PRESERFLO™ c другими операциями. Метаанализы, посвященные сравнению PRESERFLO™ и трабекулэктомии, показывают сравнимую эффективность вмешательств с меньшим риском осложнений у PRESERFLO™. Исследования, посвященные сравнению PRESERFLO™ и микрошунта похожей конструкции XEN (Allergan, Plc, Ирландия), показывают сравнимую либо лучшую эффективность PRESERFLO™.

The current gold standard of glaucoma surgery is trabeculectomy, which allows sustained reduction of intraocular pressure (IOP). However, trabeculectomy is relatively traumatic and is associated with a risk of specific complications. As a result, a number of devices for microinvasive glaucoma surgery have been developed, designed to create a hypotensive effect comparable to trabeculectomy, coupled with minimal surgical trauma.

Microshunt PRESERFLO™ (Santen) is a polymer microshunt that facilitats the outflow of aqueous humor into the subconjunctival space with the formation of a filtering bleb. It is implanted through a subconjunctival approach, typical for trabeculectomy, however, due to the controlled aqueous outflow it minimizes the risk of complications typical for glaucoma interventions.

Long-term (up to 5 years) efficacy and safety of PRESERFLO™ microshunt implantation have been demonstrated in a number of studies, including those comparing PRESERFLO™ with other surgeries. Meta-analyses comparing PRESERFLO™ and trabeculectomy show comparable efficacy of the interventions with a lower risk of complications in PRESERFLO™. Studies comparing PRESERFLO™ with similarly designed microshunt XEN (Allergan, Plc, Ireland) show that PRESERFLO™ is either equally or more effective.

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The authors declare that there are no conflicts of interest present.