glaucomaНациональный журнал ГлаукомаNational Journal glaucoma2078-41042311-6862Federal State Budgetary Institution of Science “Krasnov Research Institute of Eye Diseases”10.53432/2078-4104-2025-24-3-52-64glaucoma-585Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEW OF LITERATUREХронобиологические подходы к изучению прогрессирования первичной открытоугольной глаукомыChronobiological approaches to studying the progression of primary open-angle glaucomahttps://orcid.org/0000-0003-3679-8619МалишевскаяТ. Н.MalishevskayaT. N.

д.м.н., заведующая отделением аналитической работы, доцент кафедры непрерывного медицинского образования

105064, Москва, ул. Садовая-Черногрязская, 14/19

Dr. Sci. (Med.), Head of the Department of Analytical Work, Associate Professor at the Department of Continuing Medical Education

14/19 Sadovaya-Chernogryazskaya St., Moscow, 105064 

malishevskoff@yandex.ruhttps://orcid.org/0009-0007-2258-2207РензякЕ. В.RenziakE. V.

ассистент кафедры офтальмологии, заведующая стационарным отделением офтальмологического центра

625051, Тюмень, ул. Прокопия Артамонова, 5/11

628012, Ханты-Мансийск, ул. Калинина, 40

Assistant Professor at the Academic Department of Ophthalmology, Head of the Inpatient Department of the Ophthalmological Center

5/11 Prokopy Artamonov St., Tyumen, 625051

40 Kalinina St., Khanty-Mansiysk, 628012

https://orcid.org/0000-0003-2028-1033ГубинД. Г.GubinD. G.

д.м.н., профессор, заведующий лабораторией хронобиологии и хрономедицины Университетского НИИ биотехнологий и биомедицины, профессор кафедры биологии, ведущий научный сотрудник Отделения артериальной гипертонии и коронарной недостаточности научного отдела клинической кардиологии

625150, Тюмень, ул. Одесская, 54

625026, Тюмень, ул. Мельникайте, 111

Dr. Sci. (Med.), Professor, Head of the Laboratory of Chronobiology and Chronomedicine at the University Research Institute of Biotechnology and Biomedicine, Professor at the Academic Department of Biology, Leading Researcher at the Department of Arterial Hypertension and Coronary Insufficiency of the Scientific Department of Clinical Cardiology

54 Odesskaya St., Tyumen, 625150

111 Melnikaite St., Tyumen, 625026

https://orcid.org/0000-0003-3104-3639КоломейчукС. Н.KolomeychukS. N.

к.б.н., заведующий лабораторией геномики, протеомики, метаболомики Университетского НИИ биотехнологий и биомедицины, старший научный сотрудник лаборатории генетики Института биологии, научный сотрудник рабочей группы по сомнологии научно-исследовательского отдела артериальной гипертензии

625150, Тюмень, ул. Одесская, 54

185910, Петрозаводск, ул. Пушкинская, 11

197341, Санкт-Петербург, ул. Аккуратова, 2

Cand. Sci. (Biol.), Head of the Laboratory of Genomics, Proteomics and Metabolomics at the University Research Institute of Biotechnology and Biomedicine, Senior Researcher at the Laboratory of Genetics at the Institute of Biology, Researcher of the Somnology Working Group at the Research Department for Arterial Hypertension

54 Odesskaya St., Tyumen, 625150

11 Pushkinskaya St., Petrozavodsk, 185910

2 Akkuratova St., Saint Petersburg, 197341

https://orcid.org/0000-0002-7729-097XЗумбулидзеН. Г.ZumbulidzeN. G.

к.м.н., доцент кафедры офтальмологии 

191015, Санкт-Петербург, ул. Кирочная, 41

Cand. Sci. (Med.), Associate Professor at the Academic Department of Ophthalmology 

41 Kirochnaya St., Saint Petersburg, 191015 

https://orcid.org/0009-0004-9449-321XЗахароваЕ. К.ZakharovaE. K.

к.м.н., заведующая офтальмологическим отделением 

677005, Якутск, ул. Свердлова, 15

Cand. Sci. (Med.), Head of Ophthalmology Department 

15 Sverdlova St., Yakutsk, 677005 

ФГБУ «НМИЦ глазных болезней им. Гельмгольца»РоссияHelmholtz National Medical Research Center of Eye DiseasesRussian FederationАНЧОО ДПО «Западно-Сибирский институт последипломного медицинского образования» ; БУ Ханты-Мансийского автономного округа — Югры «Окружная клиническая больница»РоссияWest Siberian Institute of Postgraduate Medical Education ; District Clinical Hospital of the Khanty-Mansi Autonomous Okrug – YugraRussian FederationФГБОУ ВО «Тюменский государственный медицинский университет» ; «Тюменский кардиологический научный центр, филиал Томского НИМЦ РАМН»РоссияTyumen State Medical University ; Tyumen Cardiology Research Center — branch of the Tomsk Scientific Research Center of the Russian Academy of SciencesRussian FederationФГБОУ ВО «Тюменский государственный медицинский университет» ; ФИЦ «Карельский научный центр РАН» ; ФГБУ «Национальный медицинский исследовательский центр имени В.А. Алмазова»РоссияTyumen State Medical University ; Karelian Scientific Center of the Russian Academy of Sciences ; Almazov National Medical Research CenterRussian FederationФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова»РоссияNorth-Western State Medical University named after I.I. MechnikovRussian FederationГАУ республики Саха (Якутия) «Якутская республиканская офтальмологическая больница»РоссияYakutsk Republican Ophthalmological HospitalRussian Federation2025130920252435264Copyright © Малишевская Т.Н., Рензяк Е.В., Губин Д.Г., Коломейчук С.Н., Зумбулидзе Н.Г., Захарова Е.К., 20252025Малишевская Т.Н., Рензяк Е.В., Губин Д.Г., Коломейчук С.Н., Зумбулидзе Н.Г., Захарова Е.К.Malishevskaya T.N., Renziak E.V., Gubin D.G., Kolomeychuk S.N., Zumbulidze N.G., Zakharova E.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.glaucomajournal.ru/jour/article/view/585

Достижения хронобиологии последних лет позволили по-новому взглянуть на природу комплексных изменений во временно́ й организации биологических процессов в организме, которые происходят при старении. Вероятность развития и прогрессирования первичной открытоугольной глаукомы с возрастом резко возрастает. В последние годы о глаукоме стали говорить, как о дисрегуляторной патологии, для которой характерны нарушения целостности и иерархичности системы саморегуляции и гомеостатического функционирования на уровне всего организма. В обзорной статье представлены данные зарубежных и отечественных исследователей по изучению хронобиологических аспектов в патогенезе глаукомы.

Recent advances in chronobiology have provided new insights into the nature of complex changes in the temporal reorganization of biological processes in the body that occur with aging. The risk of developing and progressing primary open-angle glaucoma (POAG) increases dramatically with age. In recent years, glaucoma has been regarded to as a dysregulatory condition characterized by impaired integrity and hierarchy in the self-regulation and homeostatic systems of the body. The review article presents data from Russian and foreign researchers on the study of chronobiological aspects in the pathogenesis of glaucoma.

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The authors declare that there are no conflicts of interest present.