glaucomaНациональный журнал ГлаукомаNational Journal glaucoma2078-41042311-6862Federal State Budgetary Institution of Science “Krasnov Research Institute of Eye Diseases”glaucoma-65Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEW OF LITERATUREКлеточные технологии в лечении заболеваний сетчаткиCellular technology in treatment of retinal diseasesАветисовС. Э.AvetisovS. E.noemail@neicon.ruЕричевВалерий ПетровичErichevV. P.postmaster@glaucomajournal.ruРадаевС. М.RadaevS. M.noemail@neicon.ruПанюшкинаЛ. А.PanyushkinaL. A.noemail@neicon.ruРещиковаВ. С.ReshchikovaV. S.noemail@neicon.ruФГБНУ «Научно-исследовательский институт глазных болезней»РоссияScientific Research Institute of Eye DiseasesRussian FederationКриоцентрРоссияCryocenterRussian Federation2015170120171427074Copyright © Аветисов С.Э., Еричев В.П., Радаев С.М., Панюшкина Л.А., Рещикова В.С., 20172017Аветисов С.Э., Еричев В.П., Радаев С.М., Панюшкина Л.А., Рещикова В.С.Avetisov S.E., Erichev V.P., Radaev S.M., Panyushkina L.A., Reshchikova V.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.glaucomajournal.ru/jour/article/view/65

В статье проанализирован опыт применения клеточных технологий в лечении дегенеративных заболеваний сетчатки. В экспериментальных исследованиях доказана способность стволовых клеток к самообновлению, миграции, интеграции и последующей диф-ференцировке в большинство типов нервных клеток сетчатки, включая фоторецепторные. Описан опыт применения и осложнения, возникающие при применении следующих видов стволовых клеток: клеток пигментного эпителия, нейрональных стволовых клеток, мезенхимальных стволовые клеток, клеток костного мозга, стволовых клеток пуповинной крови, индуцированных плюрипотентных стволовых клеток. Обсуждаются основные механизмы действия клеток, а именно: замещающая терапия и паракринный эффект. Отмечена роль стволовых клеток в индукции ангиогенеза, подавлении местной воспалительной реакции и апоптоза. В заключении авторами описывается методика применения гемопоэтических клеток пуповинной крови человека для восстановления нарушений зрения при нормотензивной глаукоме.

The article analyzes the experience of cellular technology application in the treatment of retinal degenerative diseases. Experimental studies proved the ability of stem cells for self-renewal, migration, integration and subsequent differentiation into most types of retinal nerve cells, including photoreceptors. The article describes the experience of application and complications arising from the application of the following types of stem cells: retinal pigment epithelium cells, neural stem cells, mesenchymal stem cells, bone marrow cells, cord blood stem cells, induced pluripotent stem cells. Main mechanisms of cells action are discussed, namely replacement therapy and paracrine effect. The article marks the role of stem cells in the induction of angiogenesis, suppressing the local inflammatory response and apoptosis. In conclusion, the author describes the use of hematopoietic stem cells of human umbilical cord blood for restoring visual impairment in patients with normotensive glaucoma.

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The authors declare that there are no conflicts of interest present.