Thyroid gland diseases and primary open-angle glaucoma: are they connected?
Abstract
PURPOSE: To investigate a possible association between reduced thyroid function and primary open-angle glaucoma (POAG) development.
METHODS: A retrospective study included 71 patients (57 women, 14 men) in the POAG group and 76 patients (52 women, 24 men) in the control group. In the POAG group, the average patient age was 67.12±6.47 years and in the control group — 65.30±5.97 years (p>0.5). To evaluate the thyroid function, we assessed mean levels of thyroidstimulating hormone (TSH), free thyroxine (T4), anti-thyroid peroxidase antibodies and the endocrinologist’s report. Additionally, biochemical blood indicators were measured: levels of glucose, cholesterol, high and low density lipoproteins (HDL, LDL), and triglycerides (TG).
RESULTS: Mean level of free T4 in the POAG group was significantly lower (15.05±2.2 pmol/l) than in the control group (20.65±14.5 pmol/l). Endocrine disorders were more often diagnosed in the POAG group: nodular goiter was observed in 25.35% of patients compared to 15.79% of the control subjects, chronic autoimmune thyroiditis — in 11.27% of patients and 6.58% of the control subjects. Diabetes mellitus was detected 3.7 times more frequently in the POAG group (9.86%) than in the control group (2.63%). Levels of cholesterol and TG tended to be higher in the POAG group. In 70.4% of patients, the level of cholesterol was above normal (compared to 63.2% of the control subjects) and in 12.7% of patients the TG level was above normal (compared to 7.9% of the control subjects).
CONCLUSION: The results of our study suggest that hormonal profile changes in the thyroid gland can be associated with POAG development. Apparently, thyroid disorders may be considered as a potential risk factor of primary open-angle glaucoma development.
About the Authors
I. B. Alekseev
FSBEI FPE «Russian Medical Academy of Continuing Professional Education» of the Ministry of Healthcare of the Russian Federation;
The S. Fedorov Eye Microsurgery State Institution
Russian Federation
Russian Federation
Med.Sc.D., Professor of the Ophthalmology Department, 2 Barrikadnaya St., Moscow, 123242;
Head of the Glaucoma Department, 59А Beskudnikovsky blv., Moscow, 127486
E. N. Iomdina
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation
Russian Federation
Sc.D., Professor, Principal Research Associate of the Refraction Pathology Department,
14/19 Sadovaya Chernogryazskaya St., Moscow, 105062
M. A. Aliverdieva
FSBEI FPE «Russian Medical Academy of Continuing Professional Education» of the Ministry of Healthcare of the Russian Federation;
Branch of the Federal Budgetary Institution of Healthcare «Medical Rehabilitation Centre of the Ministry of Economic Development of Russia»
Russian Federation
Russian Federation
M.D., Postgraduate, 2 Barrikadnaya St., Moscow, 123242;
Ophthalmology Department, 43 Lomonosov Ave, Moscow, 119192
A. N. Stulova
Lomonosov Moscow State University
Russian Federation
Russian Federation
Student, Faculty of Fundamental Medicine,
1 Leninskie Gory St., Moscow, 119991
O. M. Nepesova
Branch of the Federal Budgetary Institution of Healthcare «Medical Rehabilitation Centre of the Ministry of Economic Development of Russia»
Russian Federation
Russian Federation
M.D., Head of the Ophthalmology Department,
43 Lomonosov Ave, Moscow, 119192
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For citations:
Alekseev I.B., Iomdina E.N., Aliverdieva M.A., Stulova A.N., Nepesova O.M. Thyroid gland diseases and primary open-angle glaucoma: are they connected? National Journal glaucoma. 2017;16(2):63-68. (In Russ.)
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