Vascular theory of the glaucomatous optic neuropathy pathogenesis: rationale in terms of ocular blood flow anatomy and physiology. Part 1
Abstract
The review presents data on ocular blood flow anatomy and physiology that is directly related to glaucoma pathogenesis. Specifics of the ocular arterial, venous and capillary vascular bed have been comprehensively examined. Differences in blood supply to different parts of the optic nerve have been pointed out with particular focus on the fact that the posterior ciliary arteries are the only source of blood supply to the prelaminar and lamina cribrosa zones of the optic nerve, as well as the major source of blood supply to the retrolaminar zone. The amount and location of posterior ciliary arteries are individual. Particular attention has been paid to the comparison of retinal and choroidal blood flow with an emphasis on the regulation of these two sources of blood supply to the retina and optic nerve. The characteristic of “watershed areas”, which explain the features of the visual field defects in glaucoma, has been given. Features of the hemato-ophthalmic barrier, in particular the role of retinal capillaries and the retinal pigment epithelium, have been discussed. It is pointed out that the blood-optic nerve barrier, which is strong in all zones of the optic nerve, is nevertheless permeable in the optic nerve’s prelaminar zone.
About the Author
N. I. Kurysheva
The Ophthalmological Center of the Federal Medical and Biological Agency, Clinical Hospital No. 86
Russian Federation
Med.Sc.D., Professor, Head of the Diagnostic Department
Russian Federation
Med.Sc.D., Professor, Head of the Diagnostic Department
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Review
For citations:
Kurysheva N.I. Vascular theory of the glaucomatous optic neuropathy pathogenesis: rationale in terms of ocular blood flow anatomy and physiology. Part 1. National Journal glaucoma. 2017;16(3):90-97. (In Russ.)
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