Excessive scarring in glaucoma surgery. Part 1: Current concepts of wound healing in glaucoma surgery
https://doi.org/10.53432/2078-4104-2025-24-2-84-92
Abstract
The main complication of glaucoma surgery is cicatricial changes in newly formed outflow tracts. This process leads to a repeated increase in intraocular pressure (IOP) and is the reason for a decrease in the effectiveness of glaucoma surgeries. In the cascade of successive stages of surgical wound healing, the inflammation phase is considered the most important. Reducing its severity and duration is the main goal of postoperative therapy, since excessive inflammation leads to the formation of scar tissues. In turn, its excessive suppression leads to the development of "ineffective resolution". In this case, the inflammation becomes chronic, and the next healing phase does not occur. For complete restoration of the damaged tissue architecture, the healing process must consistently go through all phases. The use of pro-resolving mediators can contribute to the correct completion of inflammation.
This review explores the physiological processes of restoration of the damaged tissue architecture, as well as the causes of cicatricial changes in the newly formed intraocular fluid outflow tracts.
Supporting agencies: the authors received no specific funding for this work
About the Authors
Yu. N. Yusef
Krasnov Research Institute of Eye Diseases
Russian Federation
Russian Federation
Dr. Sci. (Med.), Director
11A Rossolimo St., Moscow, 1190214
А. А. Antonov
Krasnov Research Institute of Eye Diseases
Russian Federation
Russian Federation
Dr. Sci. (Med.), Head of the Department of Glaucoma
11A Rossolimo St., Moscow, 1190214
А. М. Subbot
Krasnov Research Institute of Eye Diseases
Russian Federation
Russian Federation
Cand. Sci. (Med.), senior researcher, acting Head of the Laboratory of Fundamental Research in Ophthalmology
11A Rossolimo St., Moscow, 1190214
I. I. Vitkova
Krasnov Research Institute of Eye Diseases
Russian Federation
Russian Federation
postgraduate student
11A Rossolimo St., Moscow, 1190214
E. V. Emets
Krasnov Research Institute of Eye Diseases
Russian Federation
Russian Federation
junior researcher at the Laboratory of Fundamental Research in Ophthalmology
11A Rossolimo St., Moscow, 1190214
A. A. Vitkov
Krasnov Research Institute of Eye Diseases
Russian Federation
Russian Federation
junior researcher at the Department of Glaucoma
11A Rossolimo St., Moscow, 1190214
E. D. Semenov
Krasnov Research Institute of Eye Diseases
Russian Federation
Russian Federation
postgraduate student
11A Rossolimo St., Moscow, 1190214
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Review
For citations:
Yusef Yu.N., Antonov А.А., Subbot А.М., Vitkova I.I., Emets E.V., Vitkov A.A., Semenov E.D. Excessive scarring in glaucoma surgery. Part 1: Current concepts of wound healing in glaucoma surgery. National Journal glaucoma. 2025;24(2):84-92. (In Russ.) https://doi.org/10.53432/2078-4104-2025-24-2-84-92
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