Features of management of glaucoma patients with myopia
https://doi.org/10.53432/2078-4104-2025-24-3-3-10
Abstract
PURPOSE. To study the opinions of ophthalmologists on the management strategy for patients with concurrent myopia and glaucoma.
METHODS. This multicenter, scientific-analytical, descriptive, sample-based study was conducted by the "Scientific Vanguard" group of the Russian Glaucoma Society from July to September 2024 through an online survey of Russian ophthalmologists with varying experience, working in healthcare institutions of different ownership types. The developed questionnaire was hosted on a secure online platform. The study involved 302 ophthalmologists, with the overwhelming majority of clinicians (97%) working in the outpatient settings (89%) of state healthcare institutions (85%), with 6–15 years of work experience (48%), without a qualification category (44%), residing in large cities (41%) or cities with a population of over a million (44%).
RESULTS. According to respondents, patients with combined glaucoma and myopia present weekly (48%). Moderate myopia was most common (58%), as well as younger age (70%), advanced stages of glaucoma (55%), moderately elevated intraocular pressure (IOP) (71%), and normaltension glaucoma (58%), which were characterized by rapid progression (52%), absence of complaints (72%), and concurrent cardiovascular conditions (44%). IOP was most often measured using the Maklakov tonometry method (47%). Diagnosing glaucoma in these patients was considered difficult (51%), and ophthalmologists preferred lower target IOP levels (83%), which were harder to achieve (53%). Respondents avoided prescribing m-cholinomimetics (33%) and β-blockers (27%), opting more often for combination therapy (75%). Nearly all believed that these patients require additional neuroprotective treatment (97%). Most respondents considered selective laser trabeculoplasty to be less effective (44%); such patients were operated on more frequently (51%) but with lower success rates (53%) and higher complication rates (60%).
CONCLUSION. Glaucoma patients with myopia are frequently encountered and require careful long-term monitoring and personalized treatment strategies. The early onset of glaucoma and high risk of disability in this group underscore the medical and social significance of the problem and the need for a more detailed study.
About the Authors
A. V. KuroyedovRussian Federation
Dr. Sci. (Med.), Professor, Head of the Academic Department of Ophthalmology, Head of Ophthalmology Сenter
1 Ostrovityanov St., Moscow, 117997
8A Bolshaya Olenya St., Moscow, 107014
I. A. Bulakh
Russian Federation
ophthalmologist, Assistant Professor at the Academic Department of Otorhinolaryngology and Ophthalmology
30b Rabfakovskaya St., Ivanovo, 153021
8 Sheremetevskiy Ave., Ivanovo, 153012
V. V. Gorodnichii
Russian Federation
ophthalmologist
8A Bolshaya Olenya St., Moscow, 107014
A. V. Seleznev
Russian Federation
Cand. Sci. (Med.), Associate Professor at the Academic Department of Otorhinolaryngology and Ophthalmology
8 Sheremetevskiy Ave., Ivanovo, 153012
O. V. Gaponko
Russian Federation
Cand. Sci. (Med.), Associate Professor at the Academic Department of Ophthalmology, Head of the Day Patient Department at the Ophthalmology Center
1 Ostrovityanov St., Moscow, 117997
8A Bolshaya Olenya St., Moscow, 107014
References
1. Foster P.J., Jiang Y. Epidemiology of myopia. Eye (Lond) 2014; 28(2): 202-208. https://doi.org/10.1038/eye.2013.280.
2. Holden B.A., Fricke T.R., Wilson D.A. et al. Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050. Ophthalmology 2016; 123(5):1036-1042. https://doi.org/10.1016/j.ophtha.2016.01.006
3. Allison K., Patel D., Alabi O. Epidemiology of Glaucoma: The Past, Present, and Predictions for the Future. Cureus 2020; 12(11):e11686. https://doi.org/10.7759/cureus.11686
4. Knapp A. Glaucoma in Myopic Eyes. Trans Am Ophthalmol Soc 1925; 23:61-70.
5. Mitchell P., Hourihan F., Sandbach J., Wang J.J.. The relationship between glaucoma and myopia: the Blue Mountains Eye Study. Ophthalmology 1999; 106(10):2010-2015. https://doi.org/10.1016/s0161-6420(99)90416-5
6. Wu J., Hao J., Du Y. et al. The Association between Myopia and Primary Open-Angle Glaucoma: A Systematic Review and Meta-Analysis. Ophthalmic Res 2022; 65(4):387-397. https://doi.org/10.1159/000520468
7. Xu L., Wang Y., Wang S. et al. High myopia and glaucoma susceptibility the Beijing Eye Study. Ophthalmology 2007; 114(2):216-220. https://doi.org/10.1016/j.ophtha.2006.06.050
8. Chen H.S., Liu C.H., Lu D.W. Comparison of glaucoma diagnostic accuracy of macular ganglion cell complex thickness based on nonhighly myopic and highly myopic normative database. Taiwan J Ophthalmol 2016; 6(1):15-20. https://doi.org/10.1016/j.tjo.2016.01.001
9. Rolle T., Bonetti B., Mazzucco A., Dallorto L. Diagnostic ability of OCT parameters and retinal ganglion cells count in identification of glaucoma in myopic preperimetric eyes. BMC Ophthalmol 2020; 20(1):373. https://doi.org/10.1186/s12886-020-01616-5
10. Lin F.B., Da Chen S., Song Y.H. et al. Effect of medically lowering intraocular pressure in glaucoma suspects with high myopia (GSHM study): study protocol for a randomized controlled trial. Trials 2020; 21(1):813. https://doi.org/10.1186/s13063-020-04748-7
11. Yoshida T., Yoshimoto S., Nomura T. et al. Intraocular pressure-lowering effects of ripasudil on open-angle glaucoma in eyes with high myopia and pathological myopia. Sci Rep 2023; 13(1):22888. https://doi.org/10.1038/s41598-023-49782-y
12. Kazakova A.V., Eskina E.N. Glaucoma diagnostics in myopic patients. National Journal Glaucoma 2015; 14(3):87-100.
13. Zhukova S.I., Yur’yeva T.N., Pomkina I.V., Grishchuk A.S. Beta zone of peripapillary atrophy by optical coherence tomography as a biomarker of glaucoma associated with myopia. Siberian Scientific Medical Journal 2019; 39(3):45-49. https://doi.org/10.15372/SSMJ20190307
14. Zvereva O.G., Lyakhova E.A., Seleznev A.V., Gazizova I.R., Brezhnev A.Yu., Kuroyedov A.V. Differential diagnostic signs of glaucoma in patients with high myopia. National Journal Glaucoma 2020; 19(4):64-72. https://doi.org/10.25700/NJG.2020.04.08
15. Neroev V.V. Condition of Russian ophthalmology service as an aspect of the healthcare system issues. Moscow, Russian National Ophthalmology Forum, 2014. https://helmholtzeyeinstitute.ru/photo/9-30-Doklad-Neroev-VVotkrytie.pdf (Access date: 10.12.2021)
16. Chihara E., Sawada A. Atypical Nerve Fiber Layer Defects in High Myopes With High-Tension Glaucoma. Arch Ophthalmol 1990; 108(2): 228-232. https://doi.org/10.1001/archopht.1990.01070040080035
17. Akopyan A.I. Differential diagnostic criteria for changes of the optic nerve in glaucoma and myopia. Diss. (Cand. Med. Sci.). Moscow, 2008: 153 p.
18. David R., Zangwill L.M., Tessler Z., Yassur Y. The Correlation between Intraocular Pressure and Refractive Status. Arch Ophthalmol 1985, 103:1812-1815.
19. Yang Y., Li Z., Wang N. et al. Intraocular Pressure Fluctuation in Patients with Primary Open-Angle Glaucoma Combined with High Myopia. J Glaucoma 2014; 23(1):19-22. https://doi.org/10.1097/IJG.0b013e31825afc9d.
20. Guo Z.Z., Chang K., Wei X. Intraocular pressure fluctuation and the risk of glaucomatous damage deterioration: a Meta-analysis. Int J Ophthalmol 2019; 12(1):123-128. https://doi.org/10.18240/ijo.2019.01.19
21. Patel A., Patel D., Prajapati V. et al. A Study on the Association Between Myopia and Elevated Intraocular Pressure Conducted at a Tertiary Care Teaching Hospital in Gujarat, India. Cureus 2022; 14(8):e28128. https://doi.org/10.7759/cureus.28128
22. Detry-Morel M. Is myopia a risk factor for glaucoma? J Fr Ophtalmol 2011; 34(6):392-395 https://doi.org/10.1016/j.jfo.2011.03.009.
23. Erichev V.P., Petrov S.Yu., Volzhanin A.V. et al. Alpha-adrenergic receptor agonists in terms of modern views on glaucoma monitoring and treatment. Clinical Ophthalmology 2019; 19(2):87-91. https://doi.org/10.32364/2311-7729-2019-19-2-87-91
24. Cantor L.B. Brimonidine in the treatment of glaucoma and ocular hypertension. Ther Clin Risk Manag 2006; 2(4):337-346. https://doi.org/10.2147/tcrm.2006.2.4.337
25. Nitta K., Shimamoto S., Wajima R. et al. The Effect of Brimonidine 0.1% on Disc Hemorrhage in Primary Open-Angle Glaucoma Patients. Clin Ophthalmol 2020; 14:213-219. https://doi.org/10.2147/OPTH.S237969
26. Schmidt K-G., Ruckmann A., Pullinat L.E. Topical carbonic anhydrase inhibition increases ocular pulse amplitude in high tension primary open angle glaucoma. Br J Ophthalmol 1998; 82:758-762. https://doi.org/10.1136/bjo.82.7.758.
27. Martínez A., Sanchez-Salorio M. Predictors for visual field progression and the effects of treatment with dorzolamide 2% or brinzolamide 1% each added to timolol 0.5% in primary open-angle glaucoma. Acta Ophthalmol 2010; 88(5):541-552. https://doi.org/10.1111/j.1755-3768.2009.01595.x
28. Siesky B., Harris A., Kagemann L. et al. Ocular blood flow and oxygen delivery to the retina in primary open-angle glaucoma patients: the addition of dorzolamide to timolol monotherapy. Acta Ophthalmol 2010; 88(1):142-149. https://doi.org/10.1111/j.1755-3768.2009.01604.x
29. Nagornova Z.M., Kuroyedov A.V., Seleznev A.V. Comparative analysis of the efficacy and safety of fixed-dose combinations versus their individual components for open-angle glaucoma. RMJ Clinical Ophthalmology 2019; 19(1):13-19. https://doi.org/10.21689/2311-7729-2019-19-1-13-19
30. Jonas J.D., Panda-Jonas S., Ohno-Matsui K. Glaucoma in High Myopia (in Updates on Myopia. A Clinical Perspective (eds. Ang M., Wong T.Y.). Singapore, Springer, 2020:306. https://doi.org/10.1007/978-981-13-8491-2_11
Review
For citations:
Kuroyedov A.V., Bulakh I.A., Gorodnichii V.V., Seleznev A.V., Gaponko O.V. Features of management of glaucoma patients with myopia. National Journal glaucoma. 2025;24(3):3-10. (In Russ.) https://doi.org/10.53432/2078-4104-2025-24-3-3-10

















