Potential of vacuum-compression test in evaluation of corneal topographic indices for glaucoma diagnosis in young adults
https://doi.org/10.53432/2078-4104-2025-24-3-34-42
Abstract
PURPOSE. To evaluate the effectiveness of a novel loading corneal topographic test as a method for objectively determining intraocular pressure levels in the comprehensive diagnostics of glaucoma in young patients with corneal ectasia.
METHODS. Fifteen patients with glaucoma and suspected glaucoma were examined at the Vostok-Prozrenie Eye Center. The average age was 33.9±8.02 years. All patients underwent standard ophthalmological examination and additional methods, including a vacuum-compression test (VCT) with corneal topographic indices recording before and during a short-term induced increase in IOP.
RESULTS. In patients with glaucoma combined with corneal ectasia, the vacuum-compression load with induced IOP elevation revealed biomechanical and topographic changes: decreased corneal hysteresis, decreased IOP values, increased central corneal thickness and curvature, elevated anterior and posterior corneal surface elevation indices.
CONCLUSION. In patients with low corneal hysteresis or fluctuating IOP levels, all patients should undergo corneal topography to detect corneal ectasia, which may lead to underestimation of tonometry results. A stress test with recording of corneal topography during induced IOP elevation can facilitate early detection of glaucoma combined with corneal ectasia in young patients.
About the Authors
S. Yu. Anisimova
OOO Glaznoy Centr Vostok-Prozrenie
Russian Federation
Russian Federation
Dr. Sci. (Med.), Professor, ophthalmologist, Director
10 Bld. 1 Poliny Osipenko St., Moscow, 123007
L. L. Arutyunyan
Russian Medical Academy of Continuous Professional Education ; OOO Glaznoy Centr Vostok-Prozrenie
Russian Federation
Russian Federation
Dr. Sci. (Med.), Professor at the Academic Department of Ophthalmology, Head of the Diagnostics Department
2/1 Barricadnaya St., Moscow, 125993
10 Bld. 1 Poliny Osipenko St., Moscow, 123007
S. I. Anisimov
Russian University of Medicine ; OOO Glaznoy Centr Vostok-Prozrenie
Russian Federation
Russian Federation
Dr. Sci. (Med.), Professor at the Academic Department of Eye Diseases, Scientific Director
4 Dolgorukovskaya St., Moscow, 127006
10 Bld. 1 Poliny Osipenko St., Moscow, 123007
A. A. Bratchuk
OOO Glaznoy Centr Vostok-Prozrenie ; Russian Medical Academy of Continuous Professional Education
Russian Federation
Russian Federation
ophthalmologist, candidate student
10 Bld. 1 Poliny Osipenko St., Moscow, 123007
2/1 Barricadnaya St., Moscow, 125993
S. Yu. Mammadova
Russian Medical Academy of Continuous Professional Education ; OOO Glaznoy Centr Vostok-Prozrenie
Russian Federation
Russian Federation
postgraduate student, ophthalmologist
2/1 Barricadnaya St., Moscow, 125993
10 Bld. 1 Poliny Osipenko St., Moscow, 123007
References
1. Natsional’noe rukovodstvo po glaukome dlya praktikuyuschikh vrachei [National Glaucoma Guidelines for Practitioners]. Eds. Egorov E.A., Erichev V.P. Moscow, GEOTAR-Media Publ., 2019.
2. Weinreb R.N., Aung T., Medeiros F.A. The pathophysiology and treatment of glaucoma: a review. JAMA 2014; 311(18):1901-1911. https://doi.org/10.1001/jama.2014.3192.
3. Molero-Senosiain M, Morales-Fernandez L, Saenz-Frances F, PeruchoGonzalez L, García-Bella J, Garcia Feijoo J, Martinez-de-la-Casa JM. Corneal Properties in Primary Open-angle Glaucoma Assessed Through Scheimpflug Corneal Topography and Densitometry. J Glaucoma 2021; 30(5):444-450. https://doi.org/10.1097/IJG.0000000000001770.
4. Woo S.L., Kobayashi A.S., Schlegel W.A., Lawrence C. Nonlinear material properties of intact cornea and sclera. Exp Eye Res 1972; 14(1) 29-39. https://doi.org/10.1016/0014-4835(72)90139-x.
5. Johnson C.S., Mian S.I., Moroi S., et al. Role of corneal elasticity in damping of intraocular pressure. Invest Ophthalmol Vis Sci 2007; 48(6)2540-2544. https://doi.org/10.1167/iovs.06-0719.
6. Cohen E.J. Keratoconus and normal-tension glaucoma: a study of the possible association with abnormal biomechanical properties as measured by corneal hysteresis (An AOS Thesis). Trans Am Ophthalmol Soc 2009; 107:282-299. https://doi.org/10.1097/ICO.0b013e3181ca363c.
7. Khalil A.K. The Changing Face of the Cornea in a Case of Juvenile Glaucoma and Subclinical Keratoconus. Klin Monbl Augenheilkd 2024; 241(11):1249-1255. https://doi.org/10.1055/a-1819-1412.
8. Goel S, Ganger A, Gupta V. Bilateral juvenile onset primary openangle glaucoma among keratoconus patients. J Glaucoma 2015; 24(4):e25-27. https://doi.org/10.1097/IJG.0000000000000024.
9. Senthilkumar, Vijayalakshmi A.; Krishna, Shiva M.; Das, Manoranjan1; Sangoi, Komal Parin1. Bilateral Juvenile Open-Angle Glaucoma with Keratoconus: A Rare Association and Literature Review. TNOA Journal of Ophthalmic Science and Research 2019; 57(4):p 311-315. https://doi.org/10.4103/tjosr.tjosr_90_19
10. Peyman, A., Sepahvand, F., Pourazizi, M. et al. Corneal biomechanics in normal and subclinical keratoconus eyes. BMC Ophthalmol 2023; 23(1):459. https://doi.org/10.1186/s12886-023-03215-6
11. Averich V.V. Modern methods of diagnosis and monitoring of keratoconus. The EYE GLAZ 2023; 25(4):322-330. https://doi.org/10.33791/2222-4408-2023-4-322-330.
12. Krachmer J.H., Feder R.S., Belin M.W. Keratoconus and related noninflammatory corneal thinning disorders. Surv Ophthalmol 1984; 28(4):293-322.
13. Dupps WJ. Hysteresis: new mechanospeak for the ophthalmologist. J Cataract Refract Surg 2007; 31:156-162. https://doi.org/10.1016/j.jcrs.2007.07.008.
14. Alekseev V.N., Litvin I.B. Influence of corneal thickness on the level of intraocular pressure and prognosis in primary open-angle glaucoma. RMJ Clinical Ophthalmology 2008; 9(4):130-132.
15. The Iomdina EN, Bauer SM, Kotliar KE. Biomekhanika glaza: teoreticheskie aspekty i klinicheskie prilozheniya [Biomechanics of the eye: theoretical aspects and clinical applications]. Moscow, Realnoe Vremya Publ., 2015. 208 p.
16. Lu Y, Vitart V, Burdon KP, Khor CC, Bykhovskaya Y, et al. Genomewide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Nat Genet 2013; 45(2):155-163. https://doi.org/10.1038/ng.2506.
17. Arutyunyan L. L. The role of biomechanical properties of the eye in determining target pressure. Glaucoma 2007; 3:60-65.
18. Goel S, Ganger A, Gupta V. Bilateral juvenile onset primary open-angle glaucoma among keratoconus patients. J Glaucoma 2015; 24:e25-27. https://doi.org/10.1097/IJG.0000000000000024.
19. Utyama J, Martins LA, Barboza GN, Matheus RJ, Pereira CS. Juvenile primary open-angle glaucoma and keratoconus. eOftalmo 2019; 5:33-38.
20. Katiyar S, Tong J, Pensyl D, Sullivan-Mee M. Corneal Biomechanical Changes Caused by Acute Elevation of IOP in Eyes with and without Glaucoma. Optom Vis Sci 2021; 98(4):367-373. https://doi.org/10.1097/OPX.0000000000001668.
21. Myakonkaya O.S., Sarkisyan AS, Seleznev AV. et al. State-of-the-art of loading and unloading tests for glaucoma: potentialities and informative value. RMJ Clinical Ophthalmology 2021; 21(3):153-158. https://doi.org/1032364/2311-7729-2021-21-3-153-158.
22. Volkov V.V., Simakova I.L., Tikhonovskaya I.A. Evaluation of the New Compression-Perimeter Test Effectiveness in the Early Diagnosis of Glaucoma. Ophthalmology in Russia 2020; 17(2):229-237. https://doi.org/10.18008/1816-5095-2020-2-229-237
23. Volkov V.V., Sukhinina L.B., Ter-Andriasov E.L. Compression-perimetric test in express diagnostics of glaucoma and preglaucoma. Glaucoma: Collection of scientific papers. Alma-Ata, 1980. Vol. 5, pp. 43-52.
24. Anisimov S.I., Anisimova S.Yu., Smotrich E.A., Zavgorodnyaya T.S., Zolotorevsky K.A. Keratotensotopography – new diagnostic possibilities for studying biomechanical properties of the cornea. Ophthalmology in Russia 2011; 8(4):13-17.
25. Anisimov S.I., Anisimova S.Yu., Arutyunyan L.L., Nastashchuk A.D., Bratchuk A.A. Changes in topographic indicators during vacuum compression test. Modern technologies in ophthalmology 2024; 1(4(56)):63. https://doi.org/10.25276/2312-4911-2024-4-63.
26. Anisimov S.I., Anisimova S.Yu., Arutyunyan L.L., Chigovanina N.P., Lyubimova T.S. Changes in the biomechanical properties of the eye and parameters of the optic nerve head under conditions of a dosed increase in intraocular pressure. Fyodorov readings: collection of abstracts of the 10th All-Russian scientific and practical conference with international participation, edited by B.E. Malyugin. Moscow, Oftalmologiya, 2012. P. 87.
27. Anisimov S.I., Anisimova S.Yu., L.L. Arutyunyan, Chigovanina N.P. Changes in biomechanical properties of the eye and morphometric parameters of the optic nerve head under conditions of dosed vacuum-compression load. Glaucoma 2013; 2:30-37.
Review
For citations:
Anisimova S.Yu., Arutyunyan L.L., Anisimov S.I., Bratchuk A.A., Mammadova S.Yu. Potential of vacuum-compression test in evaluation of corneal topographic indices for glaucoma diagnosis in young adults. National Journal glaucoma. 2025;24(3):34-42. (In Russ.) https://doi.org/10.53432/2078-4104-2025-24-3-34-42
Views:
109
Email this article 