Pseudoexfoliative glaucoma in the current glaucoma hierarchy
https://doi.org/10.53432/2078-4104-2025-24-4-24-35
Abstract
Pseudoexfoliation syndrome (PEX) is a systemic disease characterized by the accumulation of abnormal extracellular material in various ocular structures and extraocular tissues. Numerous studies have confirmed its association with the development of pseudoexfoliative glaucoma (PEXG), which, along with typical glaucomatous features, exhibits a range of genetic, morphological, immunological, biochemical, and clinical characteristics that distinguish it from "classic" primary open-angle glaucoma. This allows PEXG to be considered not merely as a subtype of primary or secondary open-angle glaucoma but rather as a distinct form of the disease requiring — in addition to standard approaches — the development of qualitatively new, specific strategies for early diagnosis, monitoring, and medical or surgical treatment.
This article discusses the place of PEXG in current classifications, their debatable nature, possible correlations of PEX with angle-closure glaucoma and normal-tension glaucoma, and attempts to identify pathogenetically justified treatment methods. The emergence of such therapeutic options in ophthalmology may prompt a reconsideration of existing classification frameworks and the potential recognition of PEXG as a separate category.
About the Author
A. Yu. Brezhnev
Kursk State Medical University
Russian Federation
Russian Federation
Cand. Sci. (Med.), Associate Professor at the Academic Department of Ophthalmology
3 Karla Marksa St., Kursk, 305041
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Brezhnev A.Yu. Pseudoexfoliative glaucoma in the current glaucoma hierarchy. National Journal glaucoma. 2025;24(4):24-35. (In Russ.) https://doi.org/10.53432/2078-4104-2025-24-4-24-35
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