Proxofeline in patients with mild and moderate open-angle glaucoma combined with arterial hypertension

PURPOSE: To study the efficacy of Proxofeline in patients with open-angle glaucoma and arterial hypertension.

METHODS: 32 patients (37 eyes) with mild and mode­rate open-angle glaucoma were included into the study. All patients underwent a complex ophtalmological exami­nation: visual acuity, perimetry, tonometry, tonography, gonioscopy and ophthalmoscopy before the treatment and 14 days after the treatment. All patients received Proxofeline instillation twice daily (in the morning and in the evening) and had blood pressure (BP) and heart rate measured 3 times a day.

RESULTS: After 14 days of Proxofeline instillations in­traocular pressure (IOP, P0) decreased to 14.8±1.8 mm Hg due to an increase in aqueous outflow facility (С) to 0.166±0.029 and the decrease of aqueous humor production (F) to 0.74±0.18. Becker coefficient normalization is caused by P0 decrease and aqueous humor retention reduc­tion. No changes in visual acuity, perimetric parameters or ophthalmoscopic findings were registered. A mild posi­tive IOP dynamics with a decrease by 1-2 mm Hg was note in 2 patients (7% of 28 patients). It might be due to a pro­nounced 3+/4+ anterior chamber angle pigmentation, as well as the presence of synechia that appeared after irido­cyclitis. Proxopheline instillations did not cause significant fluctuations in systemic blood pressure. No changes in pulse, systolic and diastolic pressure values were regis­tered in any patients.

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