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Национальный журнал Глаукома

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Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits

https://doi.org/10.53432/2078-4104-2021-20-4-9-15

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Аннотация

Original article is published in: Frontiers in Bioscience, Landmark, 20, 892–901, January 1, 2015

Glaucoma is the main cause of irreversible blindness worldwide. This disease is characterized by apoptosis of retinal ganglion cells (RGC) and visual field loss that seems to be related to elevated intraocular pressure (IOP). Several lines of evidences have implicated the crucial role of mitochondrial dysfunction in the pathogenesis of glaucoma. Increased mitochondrial oxidative stress in RGC may underlie or contribute to susceptibility of RGC to apoptosis. In our work we (i) designed a rabbit model of chronic, moderately elevated IOP for studying glaucoma and (ii) demonstrated efficacy of mitochondria-targeted antioxidant SkQ1 as a tool to reverse several traits of experimental glaucoma induced by a series of injections of hydroxypropylmethylcellulose (HPMC) to the anterior chamber of the rabbit eye. It is shown that 6 months instillations of drops of 0.2.5–5 µM solution of SkQ1 normalize IOP and eye hydrodynamics and abolish an increase in lens thickness that accompanies glaucoma.

Об авторах

E. N. Iomdina
Moscow Helmholtz Research Institute of Eye Diseases
Россия

Elena N. Iomdina

Moscow



I. P. Khoroshilova-Maslova
Moscow Helmholtz Research Institute of Eye Diseases
Россия

Inna P. Khoroshilova-Maslova

Moscow



O. V. Robustova
Moscow Helmholtz Research Institute of Eye Diseases
Россия

Olga V. Robustova

Moscow



O. A. Averina
Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics
Россия

Olga A. Averina

Moscow 119992



N. A. Kovaleva
Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology
Россия

Nadezhda A. Kovaleva

Moscow 119992



G. Aliev
GALLY International Biomedical Research Consulting LLC; School of Health Science and Healthcare Administration, The University of Atlanta
Соединённые Штаты Америки

Gjumrakch Aliev

Texas, 78229; Johns Creek



V. P. Reddy
Department of Chemistry, Missouri University of Science and Technology
Соединённые Штаты Америки

V. Prakash Reddy

Rolla, MO 65409



A. A. Zamyatnin Jr.
Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology; Sechenov First Moscow State Medical University, Institute of Molecular Medicine
Россия

Andrey A. Zamyatnin Jr.

Moscow 119992; Moscow 119991



M. V. Skulachev
Lomonosov Moscow State University, Biological Faculty
Россия

Maxim V. Skulachev

Moscow 119991



I. I. Senin
Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology; Lomonosov Moscow State University, Institute of Mitoengineering
Россия

Ivan I. Senin

Moscow 119992



V. P. Skulachev
Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics; Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology
Россия

Vladimir P. Skulachev

Moscow 119992



Рецензия

Для цитирования:


Iomdina E.N., Khoroshilova-Maslova I.P., Robustova O.V., Averina O.A., Kovaleva N.A., Aliev G., Reddy V., Zamyatnin Jr. A.A., Skulachev M.V., Senin I.I., Skulachev V.P. Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits. Национальный журнал Глаукома. 2021;20(4):9-15. https://doi.org/10.53432/2078-4104-2021-20-4-9-15

For citation:


Iomdina E.N., Khoroshilova-Maslova I.P., Robustova O.V., Averina O.A., Kovaleva N.A., Aliev G., Reddy V.P., Zamyatnin Jr. A.A., Skulachev M.V., Senin I.I., Skulachev V.P. Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits. National Journal glaucoma. 2021;20(4):9-15. https://doi.org/10.53432/2078-4104-2021-20-4-9-15

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ISSN 2078-4104 (Print)
ISSN 2311-6862 (Online)