Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits
https://doi.org/10.53432/2078-4104-2021-20-4-9-15
Abstract
Original article is published in: Frontiers in Bioscience, Landmark, 20, 892–901, January 1, 2015
Glaucoma is the main cause of irreversible blindness worldwide. This disease is characterized by apoptosis of retinal ganglion cells (RGC) and visual field loss that seems to be related to elevated intraocular pressure (IOP). Several lines of evidences have implicated the crucial role of mitochondrial dysfunction in the pathogenesis of glaucoma. Increased mitochondrial oxidative stress in RGC may underlie or contribute to susceptibility of RGC to apoptosis. In our work we (i) designed a rabbit model of chronic, moderately elevated IOP for studying glaucoma and (ii) demonstrated efficacy of mitochondria-targeted antioxidant SkQ1 as a tool to reverse several traits of experimental glaucoma induced by a series of injections of hydroxypropylmethylcellulose (HPMC) to the anterior chamber of the rabbit eye. It is shown that 6 months instillations of drops of 0.2.5–5 µM solution of SkQ1 normalize IOP and eye hydrodynamics and abolish an increase in lens thickness that accompanies glaucoma.
Supporting agencies: The authors are grateful to RSCF (grant No 14-24-00107) for their funding of this research. The authors are also grateful to Mitotech LLC for supporting this study and providing SkQ1.
About the Authors
E. N. Iomdina
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation
Russian Federation
Elena N. Iomdina
Moscow
I. P. Khoroshilova-Maslova
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation
Russian Federation
Inna P. Khoroshilova-Maslova
Moscow
O. V. Robustova
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation
Russian Federation
Olga V. Robustova
Moscow
O. A. Averina
Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics
Russian Federation
Russian Federation
Olga A. Averina
Moscow 119992
N. A. Kovaleva
Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology
Russian Federation
Russian Federation
Nadezhda A. Kovaleva
Moscow 119992
G. Aliev
GALLY International Biomedical Research Consulting LLC; School of Health Science and Healthcare Administration, The University of Atlanta
United States
United States
Gjumrakch Aliev
San Antonio, Texas, 78229; Johns Creek
V. P. Reddy
Department of Chemistry, Missouri University of Science and Technology
United States
United States
V. Prakash Reddy
Rolla, MO 65409
A. A. Zamyatnin Jr.
Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology; Sechenov First Moscow State Medical University, Institute of Molecular Medicine
Russian Federation
Russian Federation
Andrey A. Zamyatnin Jr.
Moscow 119992; Moscow 119991
M. V. Skulachev
Lomonosov Moscow State University, Biological Faculty
Russian Federation
Russian Federation
Maxim V. Skulachev
Moscow 119991
I. I. Senin
Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology; Lomonosov Moscow State University, Institute of Mitoengineering
Russian Federation
Russian Federation
Ivan I. Senin
Moscow 119992
V. P. Skulachev
Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics; Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology
Russian Federation
Russian Federation
Vladimir P. Skulachev
Moscow 119992
Review
For citations:
Iomdina E.N., Khoroshilova-Maslova I.P., Robustova O.V., Averina O.A., Kovaleva N.A., Aliev G., Reddy V.P., Zamyatnin Jr. A.A., Skulachev M.V., Senin I.I., Skulachev V.P. Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits. National Journal glaucoma. 2021;20(4):9-15. https://doi.org/10.53432/2078-4104-2021-20-4-9-15
Views:
443
Email this article 