Clinical features of the progression of primary open-angle glaucoma in patients with a burdened family history
https://doi.org/10.53432/2078-4104-2023-22-2-44-54
Abstract
PURPOSE. To identify clinical and epidemiological features of the course of primary open-angle glaucoma (POAG) in patients with a verified family history of the disease.
METHODS. The study protocol included data from 103 people (103 eyes), among them 37 (35.9%) men and 66 (64.1%) women. Group 1 (44 people, 44 eyes) included patients with sporadic glaucoma. Group 2 consisted of patients with a hereditary form of the disease (41 people, 41 eyes). Healthy individuals (18 people, 18 eyes) comprised the control group. Mean age of all patients at the time of final examination was 60.6 (56.0; 66.3) years. In all cases, the diagnosis was established in accordance with the system of differential diagnosis of diseases. Examination was always carried out in person and included routine and specialized study methods (static automated perimetry, optical coherence tomography, examination of the thickness of the cornea in the central optical zone).
RESULTS. The mean age of patients with a family history at the time of POAG diagnosis was 59.8 (53.9; 63.1) years, in patients with sporadic glaucoma — 63.85 (58.5; 67.9) years. Therefore, POAG in the group with a family history was diagnosed 4.05 years earlier. No significant differences in the structural and functional characteristics of the visual analyzer were established. A greater number of patients with the sporadic form of the disease undergo glaucoma surgery (47.7% and 34.1%, respectively) in comparable disease duration.
CONCLUSION. In people with a family history of glaucoma, preventive screening should be carried out at an earlier age than the average in the population.
About the Authors
I. A. BulakhRussian Federation
ophthalmologist
30b Rabfakovskaya St., Ivanovo, 153021
P. Ch. Zavadski
Russian Federation
Cand. Sci. (Med.), ophthalmologist
1b Varkausa Embankment, Petrozavodsk, Republic of Karelia, 185031
S. N. Lanin
Russian Federation
Cand. Sci. (Med.), ophthalmologist
1c Nikitina St., Krasnoyarsk, 660022
O. G. Zvereva
Russian Federation
Head of Glaucoma Office; Assistant at the Academic Department of Ophthalmology
14 Butlerova St., Каzan, 420012
36 Butlerova St., Kazan, 420012
A. A. Vitkov
Russian Federation
junior researcher at the Department of Glaucoma
11A Rossolimo St., Moscow, 119021
O. V. Gaponko
Russian Federation
Cand. Sci. (Med.), ophthalmologist; Assistant at the Academic Department of Ophthalmology
8A Bolshaya Olenya St., Moscow, 107014
1 Ostrovityanova St., Moscow, 117997
V. V. Gorodnichii
Russian Federation
ophthalmologist
8A Bolshaya Olenya St., Moscow, 107014
S. V. Diordiichuk
Russian Federation
ophthalmologist
8A Bolshaya Olenya St., Moscow, 107014
D. A. Dorofeev
Russian Federation
ophthalmologist, Head of City Glaucoma Office
200 Rossiyskaya St., Chelyabinsk, 454090
A. V. Kuroyedov
Russian Federation
Dr. Sci. (Med.), Head of the Ophthalmology Centre; Professor at the Academic Department
of Ophthalmology
1 Ostrovityanova St., Moscow, 117997
A. V. Seleznev
Russian Federation
Cand. Sci. (Med.), Associate Professor at the Academic Department of Otorhinolaryngology
and Ophthalmology
8 Sheremetevskiy Av., Ivanovo, 153012
N. E. Fomin
Russian Federation
ophthalmologist; Assistant at the Academic Department of Ophthalmology
8A Bolshaya Olenya St., Moscow, 107014
1 Ostrovityanova St., Moscow, 117997
E. I. Shalygina
Russian Federation
Cand. Sci. (Med.), ophthalmologist; Assistant at the Academic Department of Ophthalmology
8A Bolshaya Olenya St., Moscow, 107014
1 Ostrovityanova St., Moscow, 117997
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Review
For citations:
Bulakh I.A., Zavadski P.Ch., Lanin S.N., Zvereva O.G., Vitkov A.A., Gaponko O.V., Gorodnichii V.V., Diordiichuk S.V., Dorofeev D.A., Kuroyedov A.V., Seleznev A.V., Fomin N.E., Shalygina E.I. Clinical features of the progression of primary open-angle glaucoma in patients with a burdened family history. National Journal glaucoma. 2023;22(2):44-54. (In Russ.) https://doi.org/10.53432/2078-4104-2023-22-2-44-54