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Clinical features of the progression of primary open-angle glaucoma in patients with a burdened family history

https://doi.org/10.53432/2078-4104-2023-22-2-44-54

Abstract

PURPOSE. To identify clinical and epidemiological features of the course of primary open-angle glaucoma (POAG) in patients with a verified family history of the disease.

METHODS. The study protocol included data from 103 people (103 eyes), among them 37 (35.9%) men and 66 (64.1%) women. Group 1 (44 people, 44 eyes) included patients with sporadic glaucoma. Group 2 consisted of patients with a hereditary form of the disease (41 people, 41 eyes). Healthy individuals (18 people, 18 eyes) comprised the control group. Mean age of all patients at the time of final examination was 60.6 (56.0; 66.3) years. In all cases, the diagnosis was established in accordance with the system of differential diagnosis of diseases. Examination was always carried out in person and included routine and specialized study methods (static automated perimetry, optical coherence tomography, examination of the thickness of the cornea in the central optical zone).

RESULTS. The mean age of patients with a family history at the time of POAG diagnosis was 59.8 (53.9; 63.1) years, in patients with sporadic glaucoma — 63.85 (58.5; 67.9) years. Therefore, POAG in the group with a family history was diagnosed 4.05 years earlier. No significant differences in the structural and functional characteristics of the visual analyzer were established. A greater number of patients with the sporadic form of the disease undergo glaucoma surgery (47.7% and 34.1%, respectively) in comparable disease duration.

CONCLUSION. In people with a family history of glaucoma, preventive screening should be carried out at an earlier age than the average in the population.

About the Authors

I. A. Bulakh
OOO Medicinskiy centr Ivastramed
Russian Federation

ophthalmologist

30b Rabfakovskaya St., Ivanovo, 153021



P. Ch. Zavadski
OOO Oftalmologicheskiy centr Karelii
Russian Federation

Cand. Sci. (Med.), ophthalmologist

1b Varkausa Embankment, Petrozavodsk, Republic of Karelia, 185031



S. N. Lanin
Krasnoyarsk Regional Ophtalmology Clinical Hospital behalf of Professor P.G. Makarov
Russian Federation

Cand. Sci. (Med.), ophthalmologist

1c Nikitina St., Krasnoyarsk, 660022



O. G. Zvereva
Adamyuk Republican Clinical Ophthalmological Hospital; Kazan State Medical Academy — branch of Russian Medical Academy of Continuous Professional Education
Russian Federation

Head of Glaucoma Office; Assistant at the Academic Department of Ophthalmology

14 Butlerova St., Каzan, 420012

36 Butlerova St., Kazan, 420012



A. A. Vitkov
Krasnov Research Institute of Eye Diseases
Russian Federation

junior researcher at the Department of Glaucoma

11A Rossolimo St., Moscow, 119021



O. V. Gaponko
Central Clinical Military Hospital named after P.V. Mandryka; Pirogov Russian National Research Medical University,
Russian Federation

Cand. Sci. (Med.), ophthalmologist; Assistant at the Academic Department of Ophthalmology

8A Bolshaya Olenya St., Moscow, 107014

1 Ostrovityanova St., Moscow, 117997



V. V. Gorodnichii
Central Clinical Military Hospital named after P.V. Mandryka
Russian Federation

ophthalmologist

8A Bolshaya Olenya St., Moscow, 107014



S. V. Diordiichuk
Central Clinical Military Hospital named after P.V. Mandryka
Russian Federation

ophthalmologist

8A Bolshaya Olenya St., Moscow, 107014



D. A. Dorofeev
Chelyabinsk Public Clinical Hospital No. 2, Polyclinic No. 1
Russian Federation

ophthalmologist, Head of City Glaucoma Office

200 Rossiyskaya St., Chelyabinsk, 454090

 



A. V. Kuroyedov
Pirogov Russian National Research Medical University
Russian Federation

Dr. Sci. (Med.), Head of the Ophthalmology Centre; Professor at the Academic Department
of Ophthalmology

1 Ostrovityanova St., Moscow, 117997



A. V. Seleznev
Ivanovo State Medical Academy
Russian Federation

Cand. Sci. (Med.), Associate Professor at the Academic Department of Otorhinolaryngology
and Ophthalmology

8 Sheremetevskiy Av., Ivanovo, 153012



N. E. Fomin
Central Clinical Military Hospital named after P.V. Mandryka; Pirogov Russian National Research Medical University
Russian Federation

ophthalmologist; Assistant at the Academic Department of Ophthalmology

8A Bolshaya Olenya St., Moscow, 107014

1 Ostrovityanova St., Moscow, 117997



E. I. Shalygina
Central Clinical Military Hospital named after P.V. Mandryka; Pirogov Russian National Research Medical University
Russian Federation

Cand. Sci. (Med.), ophthalmologist; Assistant at the Academic Department of Ophthalmology

8A Bolshaya Olenya St., Moscow, 107014

1 Ostrovityanova St., Moscow, 117997



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Review

For citations:


Bulakh I.A., Zavadski P.Ch., Lanin S.N., Zvereva O.G., Vitkov A.A., Gaponko O.V., Gorodnichii V.V., Diordiichuk S.V., Dorofeev D.A., Kuroyedov A.V., Seleznev A.V., Fomin N.E., Shalygina E.I. Clinical features of the progression of primary open-angle glaucoma in patients with a burdened family history. National Journal glaucoma. 2023;22(2):44-54. (In Russ.) https://doi.org/10.53432/2078-4104-2023-22-2-44-54

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ISSN 2078-4104 (Print)
ISSN 2311-6862 (Online)