Automated non-invasive assessment of tear film break-up time in patients with open-angle glaucoma on antihypertensive therapy and in patients with newly diagnosed glaucoma after SLT
https://doi.org/10.53432/2078-4104-2024-23-4-37-45
Abstract
PURPOSE. To evaluate the potential of corneal topography analysis in assessment of the precorneal tear film stability.
METHODS. The study included two groups of randomly selected participants: patients receiving topical hypotensive therapy, and patients with newly diagnosed primary open-angle glaucoma (POAG) who had underwent selective laser trabeculoplasty (SLT). All study participants underwent measurement of tear break-up time (TBUT) and meibomian gland dysfunction. The CSO Sirius+ topographer with software designed for diagnosing dry eye syndrome was used.
RESULTS. Patients who had been on topical therapy for various durations (ranging from 3 months to 10 years) demonstrated significant evidence of reduced TBUT, indicating the presence of dry eye syndrome. In contrast, patients who underwent SLT without receiving medication had TBUT values within normal limits.
CONCLUSION. Preliminary results of this comparative study on the use of corneal topography used for diagnosing dry eye syndrome in evaluation of tear film stability demonstrated the informative value and advantages of this method compared to conventional techniques (Schirmer’s test, Norn’s test).
About the Authors
S. Yu. Anisimova
Eye care center "East Sight Recovery"
Russian Federation
Russian Federation
Dr. Sci. (Med.), Professor, Director
10 Bld. 1 Poliny Osipenko St., Moscow, 123007
S. I. Anisimov
Russian University of Medicine ; Eye care center "East Sight Recovery"
Russian Federation
Russian Federation
Dr. Sci. (Med.), Professor at the Academic Department of Eye Diseases, Scientific Director
4 Dolgorukovskaya St., Moscow, 127006
10 Bld. 1 Poliny Osipenko St., Moscow, 123007
O. B. Kochmala
Rostov State Medical University
Russian Federation
Russian Federation
Dr. Sci. (Med.), Assistant at the Academic Department of Ophthalmology
29 Nakhichevanskiy Ln., Rostov-on-Don, 344022
Peng Ling
Rostov State Medical University
Russian Federation
Russian Federation
postgraduate student
29 Nakhichevanskiy Ln., Rostov-on-Don, 344022
N. A. Gavrilova
Russian University of Medicine
Russian Federation
Russian Federation
Dr. Sci. (Med.), Professor, Head of the Academic Department of Eye Diseases
4 Dolgorukovskaya St., Moscow, 127006
M. A. Vokuev
Russian University of Medicine
Russian Federation
Russian Federation
clinical resident
4 Dolgorukovskaya St., Moscow, 127006
References
1. Stapleton F, Alves M, Bunya VY, Jalbert I, Lekhanont K, Malet F, Na KS, Schaumberg D, Uchino M, Vehof J, Viso E, Vitale S, Jones L. TFOS DEWS II Epidemiology Report. Ocul Surf 2017; 15(3):334-365. https://doi.org/10.1016/j.jtos.2017.05.003.
2. Brzhesky V.V. Glaukoma I sindrom sukhogo glaza [Glaucoma and dry eye syndrome]. Moscow, BORGES Company, 2018. 226 p.
3. Brzhesky V.V., Еgorov Е., Еgorovа G.B. Sindrom sukhogo glaza i zabolevanie glaznoi poverkhnosti [Dry eye syndrome and ocular surface disease]. Moscow, GEOTAR-Media Publ., 2016. 464 p.
4. Erichev V.P., Filippova О.М., Lovpache J.N., Vasilenkova L.V. Dry eye syndrome and topical hypotensive therapy. Glaukoma 2002; 2:40-42.
5. Muratova N.V. “Dry eye syndrome” in patients with menopausal syndrome receiving β-blockers. Clinical ophthalmology. Diseases of the posterior part eye segment 2002; 10(3):122-123.
6. Erb C., Gast U., Schremmer D. German register for glaucoma patients with dry eye. I. Basic outcome with respect to dry eye. Graefe’s Arch Clin Exp Ophthalmol 2008; 246(11):1593-1601. https://doi.org/10.1007/s00417-008-0881-9
7. Leung E.W., Medeiros F.A., Weinreb R.N. Prevalence of ocular surface disease in glaucoma patients. Glaucoma 2008; 17(5):350-355. https://doi.org/10.1097/IJG.0b013e31815c5f4f
8. Rossi G.C., Tinelli C., Pasinetti G.M. et al. Dry eye syndromerelated quality of life in glaucoma patients. Eur J Ophthalmol 2009; 19(4):572-579. https://doi.org/10.1177/112067210901900409
9. Willcox M.D.P., Argüeso P., Georgiev G.A., Holopainen J.M., Laurie G.W., Millar T.J., et al. TFOS DEWS II tear film report. Ocul Surf 2017; 15(3):366–403. https://doi.org/10.1016/j.jtos.2017.03.006
10. Lan W., Lin L., Yang X., Yu M. Automatic noninvasive tear breakup time (TBUT) and conventional fluorescent TBUT. Optom Vis Sci 2014; 91(12):1412-1418. https://doi.org/10.1097/OPX.0000000000000418
11. Wolffsohn J.S., Arita R., Chalmers R., Djalilian A., Dogru M., Dumbleton K., et al. TFOS DEWS II diagnostic methodology report. Ocul Surf 2017; 15(3):539-574. https://doi.org/10.1016/j.jtos.2017.05.001
12. Liu H., Begley C.G., Chalmers R., Wilson G., Srinivas S.P., Wilkinson J.A. Temporal progression and spatial repeatability of tear breakup. Optom Vis Sci 2006; 83(10):723-730. https://doi.org/10.1097/01.opx.0000237546.88464.6d.
13. Bron A., Evans V.E., Smith J.A. Grading of corneal and conjunctival staining in the context of other dry eye tests. Cornea 2003; 22(7):640- 650. https://doi.org/10.1097/00003226-200310000-00008.
14. Abdelfattah N.S., Dastiridou A., Sadda S.R., Lee O.L. Noninvasive imaging of tear film dynamics in eyes with ocular surface disease. Cornea 2015; 34(Suppl 10):S48-52. https://doi.org/10.1097/ICO.0000000000000570.
15. Zhu K, Xie W, Ying J, Yao Y. Evaluation of tear film and meibomian gland function in dry eye patients using Keratograph 5M. Zhejiang Da Xue Xue Bao Yi Xue Ban 2016; 45(4):422-448. https://doi.org/10.3785/j.issn.1008-9292.2016.07.14.
16. Tian L., Qu J.H., Zhang X.Y., Sun X.G. Repeatability and reproducibility of noninvasive Keratograph 5M measurements in patients with dry eye disease. J Ophthalmol 2016; 2016:8013621. https://doi.org/10.1155/2016/8013621.
17. Wang X., Lu X., Yang J., Wei R., Yang L., Zhao S., Wang X. Evaluation of dry eye and Meibomian gland dysfunction in teenagers with myopia through noninvasive Keratograph. J Ophthalmol 2016; 2016:6761206. https://doi.org/10.1155/2016/6761206.
18. Pérez-Bartolomé F., Martínez-de-la-Casa J.M., Arriola-Villalobos P., Fernández-Pérez C., Polo V., García-Feijoó J. Ocular surface disease in patients under topical treatment for Glaucoma. Eur J Ophthalmol 2017; 27(6):694-704. https://doi.org/10.5301/ejo.5000977.
19. Pérez Bartolomé F., de la Casa J.M. M., Arriola Villalobos P., Fernández Pérez C., Polo V., Sánchez Jean R., et al. Ocular redness measured with the Keratograph 5M in patients using anti-Glaucoma eye drops. Semin Ophthalmol 2018; 33(5):643-650. https://doi.org/10.1080/08820538.2017.1395891.
20. Ji Y.W., Lee J., Lee H., Seo K.Y., Kim E.K., Kim T.I. Automated measurement of tear film dynamics and lipid layer thickness for assessment of non-Sjögren dry eye syndrome with Meibomian gland dysfunction. Cornea 2017; 36(2):176-182. https://doi.org/10.1097/ICO.0000000000001101.
21. Wan-Hua Cho, Ing-Chou Lai, Po-Chiung Fang et al. Meibomiam gland performance in glaucomatous patients with long term installation of IOP-lowering medications. Journal of Glaucoma 2015; 27(2):176-183. https://doi.org/10.1097/IJG.0000000000000841.
Review
For citations:
Anisimova S.Yu., Anisimov S.I., Kochmala O.B., Ling P., Gavrilova N.A., Vokuev M.A. Automated non-invasive assessment of tear film break-up time in patients with open-angle glaucoma on antihypertensive therapy and in patients with newly diagnosed glaucoma after SLT. National Journal glaucoma. 2024;23(4):37-45. (In Russ.) https://doi.org/10.53432/2078-4104-2024-23-4-37-45
Views:
208
Email this article 