Peripapillary choriocapillaris blood flow in glaucoma. Part 2. Peripapillary choriocapillaris dropout and its relationship to the progression of glaucomatous optic neuropathy
https://doi.org/10.53432/2078-4104-2024-23-4-54-59
Abstract
Choriocapillaris dropout within the beta zone of peripapillary choroidal atrophy is a significant marker in glaucoma diagnosis. This marker is associated with retinal nerve fiber layer thinning, retinal ganglion cell loss, and visual field deterioration. This review highlights data showing a correlation between choriocapillaris blood flow and the progression of glaucomatous optic neuropathy, suggesting that choriocapillaris dropout serves as a vital biomarker for glaucoma progression, and provides literature evidence on how choriocapillaris blood flow changes relate to glaucoma treatment.
About the Authors
N. I. KuryshevaRussian Federation
Dr. Sci. (Med.), Professor, Head of the Academic Department of Ophthalmology, Head of the Consultative and Diagnostic Department
46-8 Zhivopisnaya St., Moscow, 123098
15 Gamalei St., Moscow, 123098
V. Yu. Kim
Russian Federation
ophthalmologist at the Consultative and Diagnostic Department, Assistant Professor at the Academic Department of Ophthalmology
15 Gamalei St., Moscow, 123098
46-8 Zhivopisnaya St., Moscow, 123098
V. E. Kim
Russian Federation
ophthalmologist at the Consultative and Diagnostic Department, Assistant Professor at the Academic Department of Ophthalmology
15 Gamalei St., Moscow, 123098
46-8 Zhivopisnaya St., Moscow, 123098
References
1. Suh MH, Zangwill LM, Manalastas PI, et al. Deep Retinal Layer Microvasculature Dropout Detected by the Optical Coherence Tomography Angiography in Glaucoma. Ophthalmology 2016; 123(12):2509-2518. https://doi.org/10.1016/j.ophtha.2016.09.002
2. Kwon JM, Weinreb RN, Zangwill LM, Suh MH. Parapapillary DeepLayer Microvasculature Dropout and Visual Field Progression in Glaucoma. Am J Ophthalmol 2019; 200:65-75. https://doi.org/10.1016/j.ajo.2018.12.007
3. Rao HL, Srinivasan T, Pradhan ZS, et al. Optical Coherence Tomography Angiography and Visual Field Progression in Primary Angle Closure Glaucoma. J Glaucoma 2021; 30(3):e61-e67. https://doi.org/10.1097/IJG.0000000000001745
4. Lee SH, Kim TW, Lee EJ et al. Focal lamina cribrosa defects are not associated with steep lamina cribrosa curvature but with choroidal microvascular dropout. Sci Rep 2020; 10:6761. https://doi.org/10.1038/s41598-020-63681-6
5. Kwon JM, Weinreb RN, Zangwill LM, Suh MH. Juxtapapillary DeepLayer Microvasculature Dropout and Retinal Nerve Fiber Layer Thinning in Glaucoma. Am J Ophthalmol 2021; 227:154-165. https://doi.org/10.1016/j.ajo.2021.02.014
6. Suh MH, Zangwill LM, Manalastas PIC, et al. Deep-Layer Microvasculature Dropout by Optical Coherence Tomography Angiography and Microstructure of Parapapillary Atrophy. Invest Ophthalmol Vis Sci 2018; 59(5):1995-2004. https://doi.org/10.1167/iovs.17-23046
7. Suh MH, Na JH, Zangwill LM, Weinreb RN. Deep-layer Microvasculature Dropout in Preperimetric Glaucoma Patients. J Glaucoma 2020; 29(6):423-428. https://doi.org/10.1097/IJG.0000000000001489
8. Shin JW, Jo YH, Song MK, Won HJ, Kook MS. Nocturnal blood pressure dip and parapapillary choroidal microvasculature dropout in normal-tension glaucoma. Sci Rep 2021; 11(1):206. https://doi.org/10.1038/s41598-020-80705-3
9. Lee EJ, Kim JA, Kim TW. Influence of Choroidal Microvasculature Dropout on the Rate of Glaucomatous Progression: A Prospective Study. Ophthalmol Glaucoma 2020; 3(1):25-31. https://doi.org/10.1016/j.ogla.2019.10.001
10. Kim JA, Lee EJ, Kim TW. Evaluation of Parapapillary Choroidal Microvasculature Dropout and Progressive Retinal Nerve Fiber Layer Thinning in Patients With Glaucoma. JAMA Ophthalmol 2019; 137(7):810-816. https://doi.org/10.1001/jamaophthalmol.2019.1212
11. Lin S, Cheng H, Zhang S, et al. Parapapillary Choroidal Microvasculature Dropout Is Associated With the Decrease in Retinal Nerve Fiber Layer Thickness: A Prospective Study. Invest Ophthalmol Vis Sci 2019; 60(2):838-842. https://doi.org/10.1167/iovs.18-26115
12. Jo YH, Shin JW, Song MK, Won HJ, Kook MS. Baseline Choroidal Microvasculature Dropout as a Predictor of Subsequent Visual Field Progression in Open-angle Glaucoma. J Glaucoma 2021; 30(8):672-681. https://doi.org/10.1097/IJG.0000000000001853
13. Yoon J, Lee A, Song WK et al. Association of superficial macular vessel density with visual field progression in open-angle glaucoma with central visual field damage. Sci Rep 2023; 13(1):7190. https://doi.org/10.1038/s41598-023-34000-6
14. Igarashi R, Ochiai S, Akagi T, et al. Parapapillary choroidal microvasculature dropout in eyes with primary open-angle glaucoma. Sci Rep 2023; 13(1):20601. https://doi.org/10.1038/s41598-023-48102-8
15. Micheletti E, Moghimi S, Nishida T, et al. Factors associated with choroidal microvascular dropout change. Br J Ophthalmol 2023; 107(10):1444-1451. https://doi.org/10.1136/bjo-2022-321157
16. Suh MH, Zangwill LM, Manalastas PI, et al. Optical Coherence Tomography Angiography Vessel Density in Glaucomatous Eyes with Focal Lamina Cribrosa Defects. Ophthalmology 2016; 123(11):2309-2317. https://doi.org/10.1016/j.ophtha.2016.07.023
17. Kurysheva N.I., Kim V.Yu., Kim V.E., Laver A.B. Lamina cribrosa curvature index and its relationship with morphofunctional and microcirculatory disorders in glaucoma. National Journal glaucoma 2023; 22(3):15-25. https://doi.org/10.53432/2078-4104-2023-22-3-15-25
18. Kurysheva NI. The role of retinal microcirculation disorders in the progression of glaucomatous optic neuropathy. Russian Annals of Ophthalmology 2020; 136(4):57-65. https://doi.org/10.17116/oftalma202013604157
19. Burgoyne CF, Downs JC. Premise and prediction-how optic nerve head biomechanics underlies the susceptibility and clinical behavior of the aged optic nerve head. J Glaucoma 2008; 17(4):318-328. https://doi.org/10.1097/IJG.0b013e31815a343b
20. Akagi T, Zangwill LM, Shoji T, et al. Optic disc microvasculature dropout in primary open-angle glaucoma measured with optical coherence tomography angiography. PLoS One 2018; 13(8):e0201729. https://doi.org/10.1371/journal.pone.0201729
21. Lee JY, Shin JW, Song MK, Hong JW, Kook MS. An Increased Choroidal Microvasculature Dropout Size is Associated With Progressive Visual Field Loss in Open-Angle Glaucoma. Am J Ophthalmol 2021; 223:205-219. https://doi.org/10.1016/j.ajo.2020.10.018
22. Kim JA, Kim TW, Lee EJ, Girard MJA, Mari JM. Comparison of Lamina Cribrosa Morphology in Eyes with Ocular Hypertension and NormalTension Glaucoma. Invest Ophthalmol Vis Sci 2020; 61(4):4. https://doi.org/10.1167/iovs.61.4.4
23. Lee EJ, Kee HJ, Park KA, Han JC, Kee C. Comparative Topographical Analysis of Choroidal Microvascular Dropout Between Glaucoma and Nonarteritic Anterior Ischemic Optic Neuropathy. Invest Ophthalmol Vis Sci 2021; 62(13):27. https://doi.org/10.1167/iovs.62.13.27
24. Lee A, Shin JW, Lee JY, Baek MS, Kook MS. Vasculature-function relationship in open-angle glaucomatous eyes with a choroidal microvasculature dropout [published correction appears in Sci Rep. 2023; 13(1):915]. Sci Rep 2022; 12(1):19507. https://doi.org/10.1038/s41598-022-23109-9
25. Lee EJ, Song JE, Hwang HS, Kim JA, Lee SH, Kim TW. Choroidal Microvasculature Dropout in the Absence of Parapapillary Atrophy in POAG. Invest Ophthalmol Vis Sci 2023; 64(3):21. https://doi.org/10.1167/iovs.64.3.21
26. Cheng W, Song Y, Li F, et al. Longitudinal Choriocapillaris Vascular Density Changes in Different Types of Primary Open-Angle Glaucoma. Transl Vis Sci Technol 2023; 12(1):21. https://doi.org/10.1167/tvst.12.1.21
27. Kim JA, Kim TW, Lee EJ, Girard MJA, Mari JM. Microvascular Changes in Peripapillary and Optic Nerve Head Tissues After Trabeculectomy in Primary Open-Angle Glaucoma. Invest Ophthalmol Vis Sci 2018; 59(11):4614-4621. https://doi.org/10.1167/iovs.18-25038
28. Shin JW, Sung KR, Uhm KB, et al. Peripapillary Microvascular Improvement and Lamina Cribrosa Depth Reduction After Trabeculectomy in Primary Open-Angle Glaucoma. Invest Ophthalmol Vis Sci 2017; 58(13):5993-5999. https://doi.org/10.1167/iovs.17-22787
Review
For citations:
Kurysheva N.I., Kim V.Yu., Kim V.E. Peripapillary choriocapillaris blood flow in glaucoma. Part 2. Peripapillary choriocapillaris dropout and its relationship to the progression of glaucomatous optic neuropathy. National Journal glaucoma. 2024;23(4):54-59. (In Russ.) https://doi.org/10.53432/2078-4104-2024-23-4-54-59