Features of daily patterns of biometric and structural parameters of the optic nerve in patients with primary open-angle glaucoma
https://doi.org/10.53432/2078-4104-2025-24-4-45-50
Abstract
PURPOSE. To study the features of daily fluctuations in the biometric and structural parameters of the optic nerve (ON) in patients with different stages of primary open-angle glaucoma (POAG).
METHODS. The study included 105 patients with POAG at various stages. The control group consisted of 20 individuals without glaucoma. Daily patterns of biometric and structural parameters of the ON were analyzed in addition to standard ophthalmic examination.
RESULTS. Ultrasonographic examination of the ON over a 12-hour period (from 8:00 to 20:00) revealed a statistically significant reduction in ON thickness, both with and without its sheaths, in patients with advanced POAG compared with the control group (p<0.05). In eyes with advanced glaucoma, acoustic density (AD) of the ON and its sheaths showed a statistically significant increase compared with normal values (p<0.05).
CONCLUSION. Marked alterations in the acoustic parameters of the ON characteristic of advanced POAG may indicate pronounced internal structural changes and atrophic damage of the nerve.
About the Authors
E. V. Renziak
West Siberian Institute of Postgraduate Medical Education; District Clinical Hospital
Russian Federation
Russian Federation
Assistant Professor at the Department of Ophthalmology, Head of the Inpatient Department of the Ophthalmological Center
5/11 ProkopiyaArtamonov St., Tyumen, 625051
40 Kalinina St., Khanty-Mansiysk, 628012
T. N. Malishevskaya
Helmholtz National Medical Research Center of Eye Diseases
Russian Federation
Russian Federation
Dr. Sci. (Med.), Head of the Department of Analytical Work, Associate Professor of the Department of Continuing Medical Education
14/19 Sadovaya-Chernogryazskaya St., Moscow, 105064
N. G. Zumbulidze
North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
Cand. Sci. (Med.), Associate Professor at the Ophthalmology Department
1 Kirochnaya St., Saint Petersburg, 191015
A. S. Vlasova
West Siberian Institute of Postgraduate Medical Education
Russian Federation
Russian Federation
Cand. Sci. (Med.), Assistant Professor of the Department of Ophthalmology
5/11 ProkopiyaArtamonov St., Tyumen, 625051
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Review
For citations:
Renziak E.V., Malishevskaya T.N., Zumbulidze N.G., Vlasova A.S. Features of daily patterns of biometric and structural parameters of the optic nerve in patients with primary open-angle glaucoma. National Journal glaucoma. 2025;24(4):45-50. (In Russ.) https://doi.org/10.53432/2078-4104-2025-24-4-45-50
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