Clinical features of the progression of primary open-angle glaucoma in patients with a verified family history of the disease (new results)
https://doi.org/10.53432/2078-4104-2026-25-2-38-46
Abstract
PURPOSE. To identify clinical and epidemiological features of the course of primary open-angle glaucoma (POAG) in patients with a verified family history of the disease.
METHODS. This work is part of a multicenter study conducted across six clinical sites in different regions of the Russian Federation. The analysis included data from 134 individuals (134 eyes), of whom 51 (38%) were men and 83 (62%) were women. Group 1 (60 patients, 60 eyes) comprised individuals with sporadic glaucoma, while group 2 (56 patients, 56 eyes) included patients with hereditary glaucoma. The control group consisted of 18 healthy subjects (18 eyes). The mean age of all participants was 68.1 (62.6; 72.4) years. Standard and specialized glaucoma examinations were performed.
RESULTS. The mean age at POAG diagnosis in patients with sporadic glaucoma was 64.5 (59; 67.9) years, whereas in patients with a burdened family history it was 5.9 years younger, amounting to 58.6 (54.6; 61.5) years. Statistically significant differences between groups 1 and 2 were found in the mean thickness of the ganglion cell complex — 26 (24; 28) µm and 25 (22; 27.5) µm, respectively; lamina cribrosa depth — 450.5 (360; 585) µm and 512.5 (437; 631) µm; Bruch’s membrane to inner limiting membrane distance — 198.5 (163.5; 265.5) µm and 155.5 (110; 225.5) µm; and macular retinal thickness — 274.5 (261; 286) µm and 262 (246.5; 273) µm. Patients with a burdened family history were significantly less satisfied with their current condition (63.96 points) compared to the patients with sporadic POAG (83.51 points).
CONCLUSION. Preventive screening in individuals with a burdened family history should be initiated at an earlier age. Optical coherence tomography should be regarded as one of the most sensitive diagnostic tools, particularly at early disease stages. Patients with a hereditary burden should also be advised to seek psychological counseling to improve their psycho-emotional status.
About the Authors
I. A. Bulakh
OOO Meditsnskiy tsentr Ivastramed ; Ivanovo State Medical University
Russian Federation
Russian Federation
ophthalmologist, Assistant at the Academic Department of Otorhinolaryngology and Ophthalmology
30b Rabfakovskaya St., Ivanovo, 153021
8 Sheremetevskiy Prospekt, Ivanovo, 153012
P. Ch. Zavadski
OOO Oftalmologicheskiy tsentr Karelii
Russian Federation
Russian Federation
Cand. Sci. (Med.), ophthalmologist
1b Varkausa Embarkment, Petrozavodsk, Republic of Karelia, 185031
A. V. Kuroyedov
Mandryka Central Clinical Military Hospital ; Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Dr. Sci. (Med.), Professor, Head of the Academic Department of Ophthalmology, Head of Ophthalmological Сenter
8A Bolshaya Olenya St., Moscow, 107014
1 Ostrovityanov St., Moscow, 117997
A. V. Seleznev
Ivanovo State Medical University
Russian Federation
Russian Federation
Cand. Sci. (Med.), Associate Professor at the Academic Department of Otorhinolaryngology and Ophthalmology
8 Sheremetevskiy Prospekt, Ivanovo, 153012
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For citations:
Bulakh I.A., Zavadski P.Ch., Kuroyedov A.V., Seleznev A.V. Clinical features of the progression of primary open-angle glaucoma in patients with a verified family history of the disease (new results). National Journal glaucoma. 2026;25(2):38-46. (In Russ.) https://doi.org/10.53432/2078-4104-2026-25-2-38-46
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