Применение каннабиноидов в медицине и офтальмологии

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Аннотация

В обзоре дается описание терминологии, истории, законодательного регулирования, фармакодинамики и фармакокинетики каннабиноидов, а также результаты исследований их применения в терапии онкологических заболеваний, связанной с химиотерапией симптоматики (интенсивный болевой синдром, тошнота) и неврологических заболеваний (рассеянный склероз, болезнь Альцгеймера, шизофрения). Приведены результаты исследований системного применения каннабиноидов по снижению внутриглазного давления у здоровых лиц и пациентов с различными формами глаукомы. Описаны данные последних исследований взаимосвязи эндоканнабиноидной системы и регуляции тока внутриглазной жидкости, а также сосудорасширяющего и нейропротекторного эффектов. Приведены официальные позиции международных офтальмологических сообществ, не рекомендующих применение каннабиноидов в терапии глаукомы по причине краткосрочного гипотензивного эффекта и низкого системного уровня безопасности.

Об авторах

Сергей Юрьевич Петров
ФГБНУ «НИИ глазных болезней»
Россия


С. В. Вострухин
ФГБНУ «НИИ глазных болезней»
Россия


Д. М. Сафонова
ФГБНУ «НИИ глазных болезней»
Россия


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Дополнительные файлы

Для цитирования: Петров С.Ю., Вострухин С.В., Сафонова Д.М. Применение каннабиноидов в медицине и офтальмологии. Национальный журнал глаукома. 2016;15(4):95-100.

For citation: Petrov S.Y., Vostrukhin S.V., Safonova D.M. The use of cannabinoids in medicine and ophthalmology. National Journal glaucoma. 2016;15(4):95-100. (In Russ.)

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