Evaluation of morphometric parameters of optic nerve head and retina in congenital glaucoma in premature infants
Abstract
PURPOSE: To study the morphometric parameters of the optic nerve head and retina in premature infants with congenital glaucoma.
METHODS: Children with congenital glaucoma (21 children) with favorable outcomes of 1-3 stages of retinopathy of prematurity (RP) aged from 6 months to 12 years were examined (group I). The control group consisted of 32 fullterm children with congenital glaucoma (group II). In addition to the standard methods of examination, Heidelberg retinal tomography (HRT) and optical coherence tomography (Spectralis-OCT) of optic nerve head (ONH) and retina were used.
RESULTS: According to clinical manifestations of glaucoma, there were no significant differences between the groups. Both children with 1-2 stage of RP and congenital glaucoma and full-term infants with congenital glaucoma revealed the same pronounced morphometric changes in structures of the disk and peripapillary zone of the retina, which were characteristic for the development of glaucomatous optic neuropathy and intensified in the course of glaucoma progression. ONH changes interpretation in RP infants was hampered by traction deformation of the ONH and displacement of the central vessel trunk, especially in patients with stage 3 RP. We have not revealed a clear link between the changes in the optic nerve disk and IOP level.
CONCLUSION: Morphometric parameters measurement and a number of pathognomonic symptoms of optic nerve and peripapillary retina damage in congenital glaucoma in premature infants identified in this paper are necessary for studying the pathogenesis of glaucomatous process in RP, clarifying the diagnosis, determining the disease prognosis, assessing glaucoma progression and developing treatment tactics
About the Authors
L. V. Kogoleva
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation
Russian Federation
Med.Sc.D., Head of Pediatric Consultative Department;
14/19 Sadovaya-Chernogriazskaya, Moscow, Russian Federation, 105062
E. V. Mazanova
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation
Russian Federation
Ph.D., Research Associate, Pediatric Ophthalmology Department;
14/19 Sadovaya-Chernogriazskaya, Moscow, Russian Federation, 105062
L. A. Katargina
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation
Russian Federation
Med.Sc.D., professor, Deputy Director for Science, Head of Pediatric Ophthalmology Department.
14/19 Sadovaya-Chernogriazskaya, Moscow, Russian Federation, 105062
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Review
For citations:
Kogoleva L.V., Mazanova E.V., Katargina L.A. Evaluation of morphometric parameters of optic nerve head and retina in congenital glaucoma in premature infants. National Journal glaucoma. 2018;17(2):20-26. (In Russ.)
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