Artificial “dry” eye syndrome induced by long-term ophthalmic hypotensive therapy. Possibilities of medical correction
https://doi.org/10.25700/NJG.2020.01.08
Abstract
This article discusses the effect of prolonged instillations of ophthalmic antihypertensive drops on the ocular surface tissue, as one of the pathogenetic factors contributing to the occurrence of artifical or secondary dry eye syndrome (DES). It is known that the vast majority of antiglaucoma drops contain a preservative for the prevention of bacterial contamination of the vial: prolonging the shelf life of drops, the preservative prevents biodegradation and preserves the effectiveness of the drug, allowing you to use a convenient and safe bottle.The most common preservative, to date, is still benzalkonium chloride (BAK). But another thing is known: even at a minimum concentration, ВАК is able to have a cytotoxic effect on all structures of the eye surface. Even at a minimal concentration, BАК is capable of exerting a cytotoxic effect on all structures of the ocular surface. It is possible to reduce the toxic effects of the preservative on the ocular surface and stop the symptoms of DES using tear replacement therapy. The artificial tears replacement therapy proposed in the article is non-preservative, and the active substances that make up the preparations have proven effectiveness in the treatment and prevention of ocular surface xerosis.
About the Authors
V. P. Erichev
Scientific Research Institute of Eye Diseases
Russian Federation
Med.Sc.D., Professor, Head of Glaucoma Department
Russian Federation
Med.Sc.D., Professor, Head of Glaucoma Department
V. V. Averich
Scientific Research Institute of Eye Diseases
Russian Federation
M.D., Ph.D., Junior Science researcher of Refractive Department
Russian Federation
M.D., Ph.D., Junior Science researcher of Refractive Department
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Review
For citations:
Erichev V.P., Averich V.V. Artificial “dry” eye syndrome induced by long-term ophthalmic hypotensive therapy. Possibilities of medical correction. National Journal glaucoma. 2020;19(1):55-60. (In Russ.) https://doi.org/10.25700/NJG.2020.01.08
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