Study of the role of chorioid and lens in the development of primary anterior chamber angle closure
Abstract
PURPOSE. To study the role of the choroid and lens in the development of primary anterior chamber angle closure.
MATERIAL AND METHODS. The study included 90 patients aged 47 to 80 (30 with primary angle closure (PAC), 30 with suspected primary angle closure (PACs), and 30 in the control group) who underwent swept source optical coherence tomography (SS-OCT). The following parameters were analyzed: subfoveolar choroidal thickness (SFCT), intraocular pressure (IOP), axial length (AL), anterior chamber depth (ACD), lens vault (LV), iris curvature (ICurv) and iris thickness (IT750), angle opening distance (AOD500, AOD750), and iridotrabecular space (TISA500, TISA750).
RESULTS. SFCT in PAC (341±59 µm) and PACs (340±51 µm) was higher than in the control group (257.0±37.0 µm, p<0.05). In PAC and PACs, the correlations of SFCT with age, AL, LV, ICurv, IT750 were revealed (all p<0.05). Also, in PAC and PACs, the correlations of LV with age, IOP, ACD, ICurv, IT750, AOD500, AOD750, TISA500, TISA750 were found (all p<0.05). Only in PAC the correlation of SFCT with IOP was determined (p=-0.476; p=0.008).
CONCLUSION. The increase in the choroidal thickness in macula compared with the control in both PACs and PAC, as well as the correlations of subfoveolar choroidal thickness with lens vault and iris parameters, suggest the involvement of the choroid in the pathogenesis of primary angle closure disease (PACD). The correlations of lens vault with IOP, the anterior chamber parameters and iris indicate the prevailing role of the lens in the development of PACD and the need for its early replacement.
About the Authors
Natalia KuryshevaRussian Federation
Doc. Sci. (Med.), Professor, Head of the Ophthalmology Department1 Head of the Consultative and Diagnostic Department2
Galina Sharova
Russian Federation
Head of the Diagnostic Ophthalmology Department, laser surgeon
Elena Belikova
Russian Federation
Associate Professor, Professor of Ophthalmology Department1General Director Deputy of Science2
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Supplementary files
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1. Fig. 1. Image of macular choroidal thickness from a horizontal SS-OCT’s scan Revo NX130, «Optopol» | |
| Subject | choroidal thickness; SS-OCT | |
| Type | Материалы исследования | |
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2. Fig. 2. Аnterior segment parameters (primary angle closure) on SS-OCT Revo NX130, «Optopol» | |
| Subject | SS-OCT | |
| Type | Материалы исследования | |
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3. Fig. 3. Choroidal thickness in macula | |
| Subject | Choroidal thickness | |
| Type | Материалы исследования | |
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For citations:
Kurysheva N., Sharova G., Belikova E. Study of the role of chorioid and lens in the development of primary anterior chamber angle closure. National Journal glaucoma. 2022;21(1).
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